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NOS2 nitric oxide synthase 2, inducible [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000625 Homo sapiens nitric oxide synthase 2, inducible (NOS2), mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol NOS2
Entrez Gene ID 4843
Full Name nitric oxide synthase 2, inducible
Synonyms HEP-NOS, INOS, NOS, NOS2A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2-q12

Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
Disorder

MIM: 163730

{Hypertension, susceptibility to}, 145500 (2); {Malaria, resistance

mRNA Protein Product Sequence Price Select
NM_000625, 206597519 NP_000616, 24041029 nitric oxide synthase, inducible ORF Sequence $1500.00
KEGG
hsa05132Salmonella infection
hsa05145Toxoplasmosis
hsa00330Arginine and proline metabolism
hsa05152Tuberculosis
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa04066HIF-1 signaling pathway
hsa04020Calcium signaling pathway
hsa04146Peroxisome
hsa05146Amoebiasis
WikiPathways
WP2037Prolactin Signaling Pathway
WP2324AGE/RAGE pathway
WP619Type II interferon signaling (IFNG)
Pathway Interaction Database
il23pathwayIL23-mediated signaling events
il12_2pathwayIL12-mediated signaling events
hif1_tfpathwayHIF-1-alpha transcription factor network
atf2_pathwayATF-2 transcription factor network
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
BIOCYC
META_PWY-4983citrulline-nitric oxide cycle
HUMAN_PWY-5004superpathway of citrulline metabolism
META_PWY-5004superpathway of citrulline metabolism
HUMAN_PWY-4983citrulline-nitric oxide cycle
Reactome
REACT_604Hemostasis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_116125Disease
REACT_23876Platelet homeostasis
REACT_121256Phagosomal maturation (early endosomal stage)
Homo sapiens (human)NOS2NP_000616.3
Pan troglodytes (chimpanzee)NOS2XP_001148238.1
Macaca mulatta (Rhesus monkey)NOS2XP_001106245.1
Canis lupus familiaris (dog)NOS2NP_001003186.1
Bos taurus (cattle)NOS2NP_001070267.1
Mus musculus (house mouse)Nos2NP_035057.1
Rattus norvegicus (Norway rat)Nos2NP_036743.3
Gallus gallus (chicken)NOS2NP_990292.1
Danio rerio (zebrafish)nos2aNP_001098407.1
Danio rerio (zebrafish)nos2bNP_001106973.1
GeneCards NOS2
PDB 2LL6, 3HR4, 3EJ8, 1NSI, 2NSI, 3E7G, 4NOS
UniProt P35228
MIM 163730
Ensembl ENSG00000007171
HGNC 7873
HPRD 01225

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
nitric oxide synthase, inducible
Names
nitric oxide synthase, inducible
NOS type II
NOS, type II
inducible NOS
hepatocyte NOS
inducible NO synthase
nitric oxide synthase, macrophage
peptidyl-cysteine S-nitrosylase NOS2
nitric oxide synthase 2A (inducible, hepatocytes)
NP_000616.3

Interactant



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