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NOS2 nitric oxide synthase 2, inducible [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28036 NM_000625 Homo sapiens nitric oxide synthase 2, inducible (NOS2), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28036C NM_000625 Homo sapiens nitric oxide synthase 2, inducible (NOS2), mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol NOS2
Entrez Gene ID 4843
Full Name nitric oxide synthase 2, inducible
Synonyms HEP-NOS, INOS, NOS, NOS2A
General protein information
Preferred Names
nitric oxide synthase, inducible
Names
nitric oxide synthase, inducible
NOS type II
NOS, type II
inducible NOS
hepatocyte NOS
inducible NO synthase
nitric oxide synthase, macrophage
peptidyl-cysteine S-nitrosylase NOS2
nitric oxide synthase 2A (inducible, hepatocytes)
NP_000616.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2

Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
Disorder

MIM: 163730

{Hypertension, susceptibility to}, 145500 (2); {Malaria, resistance

mRNA Protein Product Sequence Price Select
NM_000625, 206597519 NP_000616, 24041029 nitric oxide synthase, inducible ORF Sequence $1500.00
KEGG
hsa00330Arginine and proline metabolism
hsa04020Calcium signaling pathway
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa04146Peroxisome
hsa05152Tuberculosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa04066HIF-1 signaling pathway
WikiPathways
WP619Type II interferon signaling (IFNG)
WP2324AGE/RAGE pathway
WP2037Prolactin Signaling Pathway
WP2431Spinal Cord Injury
WP1995Effects of nitric oxide
Pathway Interaction Database
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
hif1_tfpathwayHIF-1-alpha transcription factor network
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
atf2_pathwayATF-2 transcription factor network
BIOCYC
META_PWY-4983citrulline-nitric oxide cycle
HUMAN_PWY-5004superpathway of citrulline metabolism
HUMAN_PWY-4983citrulline-nitric oxide cycle
Reactome
REACT_604Hemostasis
REACT_23876Platelet homeostasis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)NOS2NP_000616.3
Pan troglodytes (chimpanzee)NOS2XP_001148238.1
Macaca mulatta (Rhesus monkey)NOS2XP_001106245.1
Canis lupus familiaris (dog)NOS2XP_005624903.1
Bos taurus (cattle)NOS2NP_001070267.1
Mus musculus (house mouse)Nos2NP_035057.1
Rattus norvegicus (Norway rat)Nos2NP_036743.3
Rattus norvegicus (Norway rat)LOC497963XP_006247011.1
Gallus gallus (chicken)NOS2NP_990292.1
Danio rerio (zebrafish)nos2aNP_001098407.1
Danio rerio (zebrafish)nos2bNP_001106973.1
Xenopus (Silurana) tropicalis (western clawed frog)nos2XP_002935342.2
Process
IDNameEvidence
GO:0001666response to hypoxiaIEA
GO:0001912positive regulation of leukocyte mediated cytotoxicityTAS
GO:0002227innate immune response in mucosaNAS
GO:0006527arginine catabolic processIDA
GO:0006801superoxide metabolic processISS
GO:0006809nitric oxide biosynthetic processIDA
GO:0006954inflammatory responseIBA
GO:0007263nitric oxide mediated signal transductionIBA
GO:0007596blood coagulationTAS
GO:0009617response to bacteriumNAS
GO:0010629negative regulation of gene expressionIGI
GO:0018119peptidyl-cysteine S-nitrosylationISS
GO:0031284positive regulation of guanylate cyclase activityIBA
GO:0042127regulation of cell proliferationIEA
GO:0042177negative regulation of protein catabolic processIEA
GO:0042742defense response to bacteriumIMP
GO:0042742defense response to bacteriumISS
GO:0043457regulation of cellular respirationTAS
GO:0045776negative regulation of blood pressureIBA
GO:0045909positive regulation of vasodilationIBA
GO:0050796regulation of insulin secretionIMP
GO:0050829defense response to Gram-negative bacteriumNAS
GO:0051701interaction with hostTAS
GO:0051712positive regulation of killing of cells of other organismIMP
GO:0055114oxidation-reduction processIEA
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071346cellular response to interferon-gammaIEA
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0005622intracellularIDA
GO:0005634nucleusISS
GO:0005737cytoplasmIDA
GO:0005777peroxisomeIDA
GO:0005829cytosolIMP
GO:0005829cytosolTAS
GO:0030863cortical cytoskeletonIEA
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0003958NADPH-hemoprotein reductase activityIBA
GO:0004517nitric-oxide synthase activityIDA
GO:0005102receptor bindingIPI
GO:0005506iron ion bindingIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0010181FMN bindingISS
GO:0020037heme bindingISS
GO:0034617tetrahydrobiopterin bindingISS
GO:0034618arginine bindingISS
GO:0042803protein homodimerization activityISS
GO:0050660flavin adenine dinucleotide bindingISS
GO:0050661NADP bindingTAS
GeneCards NOS2
UniProt P35228
Vega OTTHUMG00000132445
MIM 163730
Ensembl ENSG00000007171
HGNC 7873
HPRD 01225

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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