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NOTCH1 notch 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25580 NM_017617 Homo sapiens notch 1 (NOTCH1), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu25580C NM_017617 Homo sapiens notch 1 (NOTCH1), mRNA. Customized vector On-demand TBD TBD

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Gene Symbol NOTCH1
Entrez Gene ID 4851
Full Name notch 1
Synonyms TAN1, hN1
General protein information
Preferred Names
neurogenic locus notch homolog protein 1
Names
neurogenic locus notch homolog protein 1
Notch homolog 1, translocation-associated
translocation-associated notch protein TAN-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q34.3

Summary This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 190198

Aortic valve disease, 109730 (3); Leukemia, T-cell acute

mRNA Protein Product Sequence Price Select
NM_017617, 148833507 NP_060087, 148833508 neurogenic locus notch homolog protein 1 preproprotein ORF Sequence $3500.00
KEGG
hsa04330Notch signaling pathway
hsa05020Prion diseases
hsa04320Dorso-ventral axis formation
hsa05206MicroRNAs in cancer
hsa04919Thyroid hormone signaling pathway
WikiPathways
WP1591Heart Development
WP61Delta-Notch Signaling Pathway
WP268Notch Signaling Pathway
WP2406Cardiac Progenitor Differentiation
WP2064Neural Crest Differentiation
WP2361Gastric cancer network 1
Pathway Interaction Database
ps1pathwayPresenilin action in Notch and Wnt signaling
notch_pathwayNotch signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_14835Notch-HLH transcription pathway
REACT_13698Regulation of beta-cell development
REACT_13673Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REACT_299Signaling by NOTCH
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_116125Disease
REACT_118744Pre-NOTCH Expression and Processing
REACT_118859Signaling by NOTCH1
REACT_118568Pre-NOTCH Transcription and Translation
REACT_118722Pre-NOTCH Processing in the Endoplasmic Reticulum
REACT_118798Pre-NOTCH Processing in Golgi
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160305Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
REACT_160106Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160089Constitutive Signaling by NOTCH1 HD Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
Homo sapiens (human)NOTCH1NP_060087.3
Pan troglodytes (chimpanzee)NOTCH1XP_520371.2
Macaca mulatta (Rhesus monkey)LOC709947XP_002808138.1
Canis lupus familiaris (dog)NOTCH1XP_005625490.1
Bos taurus (cattle)NOTCH1XP_002691666.2
Mus musculus (house mouse)Notch1NP_032740.3
Rattus norvegicus (Norway rat)Notch1NP_001099191.1
Gallus gallus (chicken)NOTCH1XP_415420.4
Danio rerio (zebrafish)notch1bNP_571377.2
Drosophila melanogaster (fruit fly)NNP_001245510.1
Xenopus (Silurana) tropicalis (western clawed frog)notch1NP_001090757.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001701in utero embryonic developmentIEA
GO:0001708cell fate specificationIEA
GO:0001837epithelial to mesenchymal transitionISS
GO:0001889liver developmentIEA
GO:0001947heart loopingISS
GO:0002040sprouting angiogenesisIEA
GO:0002437inflammatory response to antigenic stimulusIEA
GO:0003157endocardium developmentISS
GO:0003160endocardium morphogenesisISS
GO:0003162atrioventricular node developmentIEA
GO:0003169coronary vein morphogenesisISS
GO:0003180aortic valve morphogenesisIMP
GO:0003181atrioventricular valve morphogenesisISS
GO:0003184pulmonary valve morphogenesisIMP
GO:0003192mitral valve formationIMP
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationISS
GO:0003203endocardial cushion morphogenesisISS
GO:0003207cardiac chamber formationISS
GO:0003208cardiac ventricle morphogenesisISS
GO:0003209cardiac atrium morphogenesisISS
GO:0003213cardiac right atrium morphogenesisISS
GO:0003214cardiac left ventricle morphogenesisISS
GO:0003219cardiac right ventricle formationIEA
GO:0003222ventricular trabecula myocardium morphogenesisISS
GO:0003241growth involved in heart morphogenesisISS
GO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationISS
GO:0003270Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferationIEA
GO:0003273cell migration involved in endocardial cushion formationISS
GO:0003344pericardium morphogenesisISS
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006955immune responseNAS
GO:0006959humoral immune responseIEA
GO:0007219Notch signaling pathwayIMP
GO:0007219Notch signaling pathwayTAS
GO:0007220Notch receptor processingTAS
GO:0007221positive regulation of transcription of Notch receptor targetISS
GO:0007368determination of left/right symmetryISS
GO:0007386compartment pattern specificationIEA
GO:0007409axonogenesisIEA
GO:0007440foregut morphogenesisIEA
GO:0007492endoderm developmentIEA
GO:0007507heart developmentIMP
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIMP
GO:0008285negative regulation of cell proliferationIDA
GO:0009912auditory receptor cell fate commitmentIEA
GO:0010001glial cell differentiationIEA
GO:0010467gene expressionTAS
GO:0010718positive regulation of epithelial to mesenchymal transitionIMP
GO:0010812negative regulation of cell-substrate adhesionIDA
GO:0010832negative regulation of myotube differentiationISS
GO:0014031mesenchymal cell developmentISS
GO:0014807regulation of somitogenesisIEA
GO:0021915neural tube developmentIEA
GO:0030216keratinocyte differentiationIEA
GO:0030279negative regulation of ossificationISS
GO:0030324lung developmentIEA
GO:0030335positive regulation of cell migrationISS
GO:0030513positive regulation of BMP signaling pathwayISS
GO:0030514negative regulation of BMP signaling pathwayISS
GO:0030900forebrain developmentIEA
GO:0031069hair follicle morphogenesisIEA
GO:0032495response to muramyl dipeptideIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035148tube formationIMP
GO:0035914skeletal muscle cell differentiationIEA
GO:0035924cellular response to vascular endothelial growth factor stimulusIDA
GO:0042640anagenIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0043086negative regulation of catalytic activityISS
GO:0045618positive regulation of keratinocyte differentiationIEA
GO:0045662negative regulation of myoblast differentiationIMP
GO:0045668negative regulation of osteoblast differentiationISS
GO:0045892negative regulation of transcription, DNA-templatedISS
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0045955negative regulation of calcium ion-dependent exocytosisIEA
GO:0046427positive regulation of JAK-STAT cascadeISS
GO:0046533negative regulation of photoreceptor cell differentiationIEA
GO:0048103somatic stem cell divisionIEA
GO:0048711positive regulation of astrocyte differentiationISS
GO:0048715negative regulation of oligodendrocyte differentiationISS
GO:0048754branching morphogenesis of an epithelial tubeIEA
GO:0050679positive regulation of epithelial cell proliferationIEA
GO:0050768negative regulation of neurogenesisISS
GO:0055008cardiac muscle tissue morphogenesisISS
GO:0060038cardiac muscle cell proliferationIEA
GO:0060045positive regulation of cardiac muscle cell proliferationISS
GO:0060253negative regulation of glial cell proliferationISS
GO:0060271cilium morphogenesisISS
GO:0060317cardiac epithelial to mesenchymal transitionISS
GO:0060411cardiac septum morphogenesisISS
GO:0060412ventricular septum morphogenesisIMP
GO:0060528secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentIEA
GO:0060740prostate gland epithelium morphogenesisIEA
GO:0060768regulation of epithelial cell proliferation involved in prostate gland developmentIEA
GO:0060842arterial endothelial cell differentiationISS
GO:0060843venous endothelial cell differentiationISS
GO:0060948cardiac vascular smooth muscle cell developmentISS
GO:0060956endocardial cell differentiationISS
GO:0060979vasculogenesis involved in coronary vascular morphogenesisISS
GO:0060982coronary artery morphogenesisISS
GO:0061314Notch signaling involved in heart developmentIMP
GO:0061384heart trabecula morphogenesisISS
GO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaISS
GO:0070986left/right axis specificationIEA
GO:0071372cellular response to follicle-stimulating hormone stimulusIDA
GO:0072017distal tubule developmentIEA
GO:0072044collecting duct developmentIEA
GO:0072144glomerular mesangial cell developmentIEA
GO:0072602interleukin-4 secretionIEA
GO:0090051negative regulation of cell migration involved in sprouting angiogenesisIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIEA
GO:0097150neuronal stem cell maintenanceIEP
GO:1901201regulation of extracellular matrix assemblyISS
GO:1902263apoptotic process involved in embryonic digit morphogenesisIEA
GO:2000737negative regulation of stem cell differentiationIMP
GO:2000811negative regulation of anoikisIMP
GO:2000974negative regulation of pro-B cell differentiationISS
GO:2001027negative regulation of endothelial cell chemotaxisIDA
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDA
GO:0005576extracellular regionTAS
GO:0005634nucleusISS
GO:0005634nucleusTAS
GO:0005654nucleoplasmTAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIEA
GO:0016021integral component of membraneIEA
GO:0043235receptor complexIDA
Function
IDNameEvidence
GO:0001047core promoter bindingISS
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionISS
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0004857enzyme inhibitor activityISS
GO:0004872receptor activityIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0019899enzyme bindingISS
GO:0031490chromatin DNA bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards NOTCH1
PDB 2HE0, 3I08, 4D0F, 3V79, 3ETO, 4CUE, 1PB5, 2F8Y, 2F8X, 2VJ3, 3L95, 4CUD, 4CUF, 1TOZ, 3NBN, 4D0E, 1YYH
UniProt P46531
Vega OTTHUMG00000020935
MIM 190198
Ensembl ENSG00000148400
HGNC 7881
HPRD 01827

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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