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NOTCH1 notch 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_017617 Homo sapiens notch 1 (NOTCH1), mRNA. ORF Sequence $3450.60
Peptide Services
Antibody Services
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Gene Symbol NOTCH1
Entrez Gene ID 4851
Full Name notch 1
Synonyms TAN1, hN1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q34.3

Summary This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 190198

Aortic valve disease, 109730 (3); Leukemia, T-cell acute

mRNA Protein Product Sequence Price Select
NM_017617, 148833507 NP_060087, 148833508 neurogenic locus notch homolog protein 1 preproprotein Full Length $0.00
ORF Sequence $3450.60
KEGG
hsa05020Prion diseases
hsa04330Notch signaling pathway
hsa04320Dorso-ventral axis formation
WikiPathways
WP61Delta-Notch Signaling Pathway
WP268Notch Signaling Pathway
WP2064Neural Crest Differentiation
WP1591Heart Development
Pathway Interaction Database
ps1pathwayPresenilin action in Notch and Wnt signaling
notch_pathwayNotch signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
Reactome
REACT_118722Pre-NOTCH Processing in the Endoplasmic Reticulum
REACT_299Signaling by NOTCH
REACT_111045Developmental Biology
REACT_118744Pre-NOTCH Expression and Processing
REACT_13698Regulation of beta-cell development
REACT_118568Pre-NOTCH Transcription and Translation
REACT_12627Generic Transcription Pathway
REACT_118859Signaling by NOTCH1
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_71Gene Expression
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_14835Notch-HLH transcription pathway
REACT_13673Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REACT_118798Pre-NOTCH Processing in Golgi
REACT_111102Signal Transduction
Homo sapiens (human)NOTCH1NP_060087.3
Pan troglodytes (chimpanzee)NOTCH1XP_520371.2
Macaca mulatta (Rhesus monkey)LOC709947XP_002808138.1
Canis lupus familiaris (dog)NOTCH1XP_537795.3
Bos taurus (cattle)NOTCH1XP_002691666.1
Mus musculus (house mouse)Notch1NP_032740.3
Rattus norvegicus (Norway rat)Notch1NP_001099191.1
Gallus gallus (chicken)NOTCH1XP_415420.3
Danio rerio (zebrafish)notch1bNP_571377.2
Drosophila melanogaster (fruit fly)NNP_476859.2
GeneCards NOTCH1
PDB 2HE0, 2F8Y, 3I08, 3L95, 2VJ3, 2F8X, 3V79, 1TOZ, 3ETO, 3NBN, 1YYH, 1PB5
UniProt P46531
MIM 190198
Ensembl ENSG00000148400
HGNC 7881
HPRD 01827

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
neurogenic locus notch homolog protein 1
Names
neurogenic locus notch homolog protein 1
Notch homolog 1, translocation-associated
translocation-associated notch protein TAN-1

Interactant

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