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Sequence in raw or FASTA format:


Blast Method:


PNP purine nucleoside phosphorylase [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22260D NM_000270 Homo sapiens purine nucleoside phosphorylase (PNP), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu22260C NM_000270 Homo sapiens purine nucleoside phosphorylase (PNP), mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol PNP
Entrez Gene ID 4860
Full Name purine nucleoside phosphorylase
Synonyms NP, PRO1837, PUNP
General protein information
Preferred Names
purine nucleoside phosphorylase
purine nucleoside phosphorylase
inosine phosphorylase
inosine-guanosine phosphorylase
purine-nucleoside:orthophosphate ribosyltransferase
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008].

MIM: 164050

Immunodeficiency due to purine nucleoside phosphorylase deficiency,

mRNA Protein Product Sequence Price Select
NM_000270, 270288734 NP_000261, 157168362 purine nucleoside phosphorylase ORF Sequence $199.00
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00760Nicotinate and nicotinamide metabolism
META_PWY-5695urate biosynthesis/inosine 5'-phosphate degradation
META_PWY-4202arsenate detoxification I (glutaredoxin)
META_PWY0-1296purine ribonucleosides degradation
HUMAN_SALVADEHYPOX-PWYadenosine nucleotides degradation II
HUMAN_SALVPURINE2-PWYxanthine and xanthosine salvage
HUMAN_PWY-4202arsenate detoxification I (glutaredoxin)
HUMAN_PWY0-1296purine ribonucleosides degradation to ribose-1-phosphate
HUMAN_PWY-6608guanosine nucleotides degradation III
HUMAN_PWY-5695urate biosynthesis/inosine 5'-phosphate degradation
HUMAN_PWY-6353purine nucleotides degradation II (aerobic)
META_PWY-6609adenine and adenosine salvage III
HUMAN_PWY-6609adenine and adenosine salvage III
HUMAN_PWY-6620guanine and guanosine salvage I
META_PWY66-409superpathway of purine nucleotide salvage (mammalia)
REACT_1923Purine salvage
REACT_2086Purine catabolism
REACT_522Purine metabolism
REACT_1698Metabolism of nucleotides
Homo sapiens (human)PNPNP_000261.2
Pan troglodytes (chimpanzee)PNPXP_001140576.1
Macaca mulatta (Rhesus monkey)LOC710245XP_001104622.1
Canis lupus familiaris (dog)PNPXP_532617.2
Bos taurus (cattle)PNPNP_001007819.1
Bos taurus (cattle)LOC790312XP_002690791.3
Mus musculus (house mouse)Pnp2NP_001116843.1
Mus musculus (house mouse)PnpNP_038660.1
Rattus norvegicus (Norway rat)PnpNP_001099501.1
Gallus gallus (chicken)PNPXP_003641950.2
Drosophila melanogaster (fruit fly)CG16758NP_001261330.1
Caenorhabditis elegansK02D7.1NP_499900.1
Xenopus (Silurana) tropicalis (western clawed frog)pnpNP_001006720.1
GO:0006139nucleobase-containing compound metabolic processIDA
GO:0006144purine nucleobase metabolic processTAS
GO:0006148inosine catabolic processIDA
GO:0006195purine nucleotide catabolic processTAS
GO:0006738nicotinamide riboside catabolic processIDA
GO:0006955immune responseIMP
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathwayIGI
GO:0034418urate biosynthetic processIDA
GO:0042102positive regulation of T cell proliferationIDA
GO:0042493response to drugIDA
GO:0042493response to drugIMP
GO:0043101purine-containing compound salvageTAS
GO:0044281small molecule metabolic processTAS
GO:0046638positive regulation of alpha-beta T cell differentiationIDA
GO:0055086nucleobase-containing small molecule metabolic processTAS
GO:0070970interleukin-2 secretionIMP
GO:0070062extracellular vesicular exosomeIDA
GO:0001882nucleoside bindingIDA
GO:0002060purine nucleobase bindingIDA
GO:0004731purine-nucleoside phosphorylase activityEXP
GO:0004731purine-nucleoside phosphorylase activityIDA
GO:0008144drug bindingIDA
GO:0042301phosphate ion bindingIDA
GeneCards PNP
PDB 2A0W, 2ON6, 1V45, 3K8Q, 1RFG, 4ECE, 1PWY, 1RCT, 3GB9, 4EB8, 1YRY, 1ULA, 1RT9, 1V41, 2A0X, 1ULB, 2OC9, 3BGS, 1PF7, 1V3Q, 1RR6, 3GGS, 3INY, 2Q7O, 1V2H, 4EAR, 4GKA, 3K8O, 1M73, 1RSZ, 3D1V, 2A0Y, 3PHB, 2OC4
UniProt V9HWH6, P00491
MIM 164050
HGNC 7892
HPRD 01247

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