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Sequence in raw or FASTA format:

Database:

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NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001037738 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 3, mRNA. ORF Sequence $226.20
Peptide Services
Antibody Services
Protein Services
NM_002520 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA. ORF Sequence $256.65
Peptide Services
Antibody Services
Protein Services
NM_199185 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 2, mRNA. ORF Sequence $231.42
Peptide Services
Antibody Services
Protein Services


Gene Symbol NPM1
Entrez Gene ID 4869
Full Name nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Synonyms B23, MGC104254, NPM
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35

Summary This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009].
Disorder

MIM: 164040

Leukemia, acute promyelocytic, NPM/RARA type (3); Leukemia, acute

mRNA Protein Product Sequence Price Select
NM_001037738, 262331549 NP_001032827, 83641870 nucleophosmin isoform 3 Full Length $390.63
ORF Sequence $226.20
NM_002520, 262331543 NP_002511, 10835063 nucleophosmin isoform 1 Full Length $420.21
ORF Sequence $256.65
NM_199185, 262331548 NP_954654, 40353734 nucleophosmin isoform 2 Full Length $394.98
ORF Sequence $231.42
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
aurora_b_pathwayAurora B signaling
bard1pathwayBARD1 signaling events
myc_activpathwayValidated targets of C-MYC transcriptional activation
Reactome
REACT_6185HIV Infection
REACT_22344Nucleosome assembly
REACT_6916Interactions of Rev with host cellular proteins
REACT_116125Disease
REACT_9395Nuclear import of Rev protein
REACT_6288Host Interactions of HIV factors
REACT_22186Deposition of New CENPA-containing Nucleosomes at the Centromere
REACT_22172Chromosome Maintenance
REACT_115566Cell Cycle
Homo sapiens (human)NPM1NP_002511.1
Macaca mulatta (Rhesus monkey)LOC702389XP_001099639.1
Canis lupus familiaris (dog)NPM1NP_001239100.1
Bos taurus (cattle)NPM1NP_001030518.1
Mus musculus (house mouse)Npm1NP_032748.1
Rattus norvegicus (Norway rat)Npm1NP_037124.1
Gallus gallus (chicken)NPM1NP_990598.1
Danio rerio (zebrafish)npm1aNP_955460.1
GeneCards NPM1
PDB 2LLH, 2P1B, 2VXD
UniProt P06748
MIM 164040
Ensembl ENSG00000181163
HGNC 7910
HPRD 01246

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
nucleophosmin
Names
nucleophosmin
nucleolar protein NO38
nucleophosmin/nucleoplasmin family, member 1

Interactant

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