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NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001037738 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_002520 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_199185 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005265920 PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006714869 PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol NPM1
Entrez Gene ID 4869
Full Name nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Synonyms B23, NPM
General protein information
Preferred Names
nucleophosmin
Names
nucleophosmin
nucleolar protein NO38
nucleophosmin/nucleoplasmin family, member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009].
Disorder

MIM: 164040

Leukemia, acute promyelocytic, NPM/RARA type (3); Leukemia, acute

mRNA Protein Product Sequence Price Select
NM_001037738, 262331549 NP_001032827, 83641870 nucleophosmin isoform 3 ORF Sequence $300.00
NM_002520, 262331543 NP_002511, 10835063 nucleophosmin isoform 1 ORF Sequence $300.00
NM_199185, 262331548 NP_954654, 40353734 nucleophosmin isoform 2 ORF Sequence $300.00
XM_005265920, 530381065 XP_005265977, 530381066 nucleophosmin isoform X2 ORF Sequence $250.00
XM_006714869, 578811123 XP_006714932, 578811124 nucleophosmin isoform X3 ORF Sequence $250.00
Pathway Interaction Database
bard1pathwayBARD1 signaling events
hif1_tfpathwayHIF-1-alpha transcription factor network
aurora_b_pathwayAurora B signaling
myc_activpathwayValidated targets of C-MYC transcriptional activation
Reactome
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6916Interactions of Rev with host cellular proteins
REACT_9395Nuclear import of Rev protein
REACT_22344Nucleosome assembly
REACT_22186Deposition of new CENPA-containing nucleosomes at the centromere
REACT_22172Chromosome Maintenance
REACT_116125Disease
REACT_115566Cell Cycle
Homo sapiens (human)NPM1NP_002511.1
Pan troglodytes (chimpanzee)NPM1NP_001238905.1
Macaca mulatta (Rhesus monkey)LOC706883XP_002804677.1
Canis lupus familiaris (dog)NPM1NP_001239100.1
Bos taurus (cattle)NPM1NP_001030518.1
Mus musculus (house mouse)Npm1NP_032748.1
Rattus norvegicus (Norway rat)Npm1NP_037124.1
Gallus gallus (chicken)NPM1NP_990598.1
Danio rerio (zebrafish)npm1aNP_955460.1
Xenopus (Silurana) tropicalis (western clawed frog)npm1NP_988883.1
Process
IDNameEvidence
GO:0006281DNA repairIDA
GO:0006334nucleosome assemblyIDA
GO:0006334nucleosome assemblyTAS
GO:0006886intracellular protein transportTAS
GO:0006913nucleocytoplasmic transportIDA
GO:0006913nucleocytoplasmic transportTAS
GO:0006950response to stressIMP
GO:0007098centrosome cycleIMP
GO:0007098centrosome cycleISS
GO:0007165signal transductionNAS
GO:0007569cell agingIMP
GO:0007569cell agingISS
GO:0008104protein localizationIDA
GO:0008285negative regulation of cell proliferationIMP
GO:0008285negative regulation of cell proliferationISS
GO:0010826negative regulation of centrosome duplicationIMP
GO:0016032viral processTAS
GO:0032071regulation of endodeoxyribonuclease activityIDA
GO:0034080centromere-specific nucleosome assemblyTAS
GO:0042255ribosome assemblyTAS
GO:0043066negative regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processNAS
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylationIDA
GO:0045727positive regulation of translationIDA
GO:0046599regulation of centriole replicationIMP
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
GO:0051259protein oligomerizationIDA
GO:0060699regulation of endoribonuclease activityIDA
GO:0060735regulation of eIF2 alpha phosphorylation by dsRNAIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusISS
GO:0005654nucleoplasmIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0005813centrosomeIDA
GO:0005813centrosomeISS
GO:0005829cytosolTAS
GO:0016020membraneIDA
GO:0030529ribonucleoprotein complexIDA
GO:0031616spindle pole centrosomeIDA
Function
IDNameEvidence
GO:0003713transcription coactivator activityIDA
GO:0003723RNA bindingIDA
GO:0004860protein kinase inhibitor activityIDA
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0030957Tat protein bindingIDA
GO:0042393histone bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0043023ribosomal large subunit bindingIDA
GO:0043024ribosomal small subunit bindingIDA
GO:0044822poly(A) RNA bindingIDA
GO:0046982protein heterodimerization activityIMP
GO:0051059NF-kappaB bindingIDA
GO:0051059NF-kappaB bindingISS
GO:0051082unfolded protein bindingIDA
GO:0051082unfolded protein bindingISS
GeneCards NPM1
UniProt P06748
Vega OTTHUMG00000130465
MIM 164040
Ensembl ENSG00000181163
HGNC 7910
HPRD 01246

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NPM1 gene?

The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the cell called the nucleolus. Nucleophosmin shuttles back and forth between the nucleus and the fluid surrounding it (the cytoplasm). It is thought to play a part in many cellular functions, including processes involved in protein formation, DNA replication, and the progression of the cell through the step-by-step process it takes to replicate itself (called the cell cycle). In the nucleolus, nucleophosmin attaches to another protein called ARF, keeping it in the proper location and protecting it from being broken down. The ARF protein is considered a tumor suppressor because it is involved in pathways that prevent cells from growing and dividing in an uncontrolled way.

Interactant

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