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ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_004320 Homo sapiens ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), transcript variant a, mRNA. ORF Sequence $865.65
Peptide Services
Antibody Services
Protein Services
NM_173201 Homo sapiens ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), transcript variant b, mRNA. ORF Sequence $1052.10
Peptide Services
Antibody Services
Protein Services


Gene Symbol ATP2A1
Entrez Gene ID 487
Full Name ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Synonyms ATP2A, SERCA1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p12.1

Summary This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder

MIM: 108730

Brody myopathy, 601003 (3)

mRNA Protein Product Sequence Price Select
NM_004320, 299829200 NP_004311, 10835220 sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform a Full Length $1249.50
ORF Sequence $865.65
NM_173201, 299829201 NP_775293, 27886529 sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform b Full Length $1234.80
ORF Sequence $1052.10
KEGG
hsa04020Calcium signaling pathway
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
WikiPathways
WP2059Alzheimers Disease
BIOCYC
HUMAN_PWY-6166calcium transport I
Reactome
REACT_23905Platelet calcium homeostasis
REACT_604Hemostasis
REACT_23765Reduction of cytosolic Ca++ levels
REACT_25300Ion channel transport
REACT_15518Transmembrane transport of small molecules
REACT_118798Pre-NOTCH Processing in Golgi
REACT_25149Ion transport by P-type ATPases
REACT_111102Signal Transduction
REACT_23876Platelet homeostasis
REACT_299Signaling by NOTCH
REACT_118744Pre-NOTCH Expression and Processing
Homo sapiens (human)ATP2A1NP_004311.1
Pan troglodytes (chimpanzee)ATP2A1XP_001142958.3
Canis lupus familiaris (dog)ATP2A1XP_860010.2
Bos taurus (cattle)ATP2A1NP_001069235.1
Mus musculus (house mouse)Atp2a1NP_031530.2
Danio rerio (zebrafish)atp2a1NP_001007030.1
Danio rerio (zebrafish)atp2a1lNP_001071001.1
Drosophila melanogaster (fruit fly)Ca-P60ANP_726382.1
Caenorhabditis eleganssca-1NP_499386.1
Arabidopsis thaliana (thale cress)ECA3NP_563860.1
GeneCards ATP2A1
UniProt O14983, Q7Z675
MIM 108730
Ensembl ENSG00000196296
HGNC 811
HPRD 00157

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 1
calcium pump 1
SR Ca(2+)-ATPase 1
endoplasmic reticulum class 1/2 Ca(2+) ATPase
calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform
NP_004311.1
NP_775293.1

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