• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001007792 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_001012331 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_002529 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol NTRK1
Entrez Gene ID 4914
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
General protein information
Preferred Names
high affinity nerve growth factor receptor
Names
high affinity nerve growth factor receptor
gp140trk
Oncogene TRK
tyrosine kinase receptor A
tropomyosin-related kinase A
TRK1-transforming tyrosine kinase protein
NP_001007793.1
NP_001012331.1
NP_002520.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21-q22

Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191315

Insensitivity to pain, congenital, with anhidrosis, 256800 (3);

mRNA Protein Product Sequence Price Select
NM_001007792, 56118209 NP_001007793, 56118210 high affinity nerve growth factor receptor isoform 3 ORF Sequence $490.00
NM_001012331, 59889557 NP_001012331, 59889558 high affinity nerve growth factor receptor isoform 1 precursor ORF Sequence $750.00
NM_002529, 59889556 NP_002520, 4585712 high affinity nerve growth factor receptor isoform 2 precursor ORF Sequence $750.00
KEGG
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa04722Neurotrophin signaling pathway
hsa04144Endocytosis
hsa05202Transcriptional misregulation in cancer
hsa04750Inflammatory mediator regulation of TRP channels
WikiPathways
WP382MAPK signaling pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
Pathway Interaction Database
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
Reactome
REACT_11061Signalling by NGF
REACT_11060TRKA activation by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12033Signalling to RAS
REACT_11064Activation of TRKA receptors
REACT_11046NGF-independant TRKA activation
REACT_12058Signalling to ERKs
REACT_12079PLC-gamma1 signalling
REACT_12049Signalling to STAT3
REACT_12076Frs2-mediated activation
REACT_12002ARMS-mediated activation
REACT_12435Retrograde neurotrophin signalling
REACT_12077Signalling to p38 via RIT and RIN
REACT_12005Prolonged ERK activation events
REACT_111102Signal Transduction
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_003308563.1
Macaca mulatta (Rhesus monkey)NTRK1XP_001114243.2
Canis lupus familiaris (dog)NTRK1XP_851619.3
Bos taurus (cattle)NTRK1XP_002686012.2
Mus musculus (house mouse)Ntrk1NP_001028296.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.5
Xenopus (Silurana) tropicalis (western clawed frog)ntrk1XP_002939035.1
Process
IDNameEvidence
GO:0000186activation of MAPKK activityTAS
GO:0006468protein phosphorylationIDA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS
GO:0007190activation of adenylate cyclase activityTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0007265Ras protein signal transductionTAS
GO:0007411axon guidanceIEA
GO:0007568agingIEA
GO:0007611learning or memoryIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0008285negative regulation of cell proliferationIDA
GO:0009314response to radiationIEA
GO:0010623developmental programmed cell deathISS
GO:0010976positive regulation of neuron projection developmentIDA
GO:0010976positive regulation of neuron projection developmentIDA
GO:0014823response to activityIEA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0021553olfactory nerve developmentIEA
GO:0030183B cell differentiationIEA
GO:0031667response to nutrient levelsIEA
GO:0032320positive regulation of Ras GTPase activityIDA
GO:0032320positive regulation of Ras GTPase activityIDA
GO:0038180nerve growth factor signaling pathwayIEA
GO:0042490mechanoreceptor differentiationIEA
GO:0042493response to drugIEA
GO:0043068positive regulation of programmed cell deathISS
GO:0043524negative regulation of neuron apoptotic processISS
GO:0045471response to ethanolIEA
GO:0045766positive regulation of angiogenesisIDA
GO:0046579positive regulation of Ras protein signal transductionIDA
GO:0046579positive regulation of Ras protein signal transductionIDA
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048485sympathetic nervous system developmentISS
GO:0048678response to axon injuryIEA
GO:0050965detection of temperature stimulus involved in sensory perception of painIEA
GO:0050966detection of mechanical stimulus involved in sensory perception of painIEA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051599response to hydrostatic pressureIEA
GO:0051602response to electrical stimulusIEA
GO:0051968positive regulation of synaptic transmission, glutamatergicIEA
GO:0060009Sertoli cell developmentIEA
GO:0060385axonogenesis involved in innervationISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0071316cellular response to nicotineIEA
GO:1990090cellular response to nerve growth factor stimulusISS
Component
IDNameEvidence
GO:0005768endosomeTAS
GO:0005769early endosomeISS
GO:0005770late endosomeISS
GO:0005886plasma membraneISS
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0009986cell surfaceIEA
GO:0030424axonIEA
GO:0030425dendriteIEA
GO:0031410cytoplasmic vesicleIEA
GO:0031901early endosome membraneIEA
GO:0031902late endosome membraneIEA
GO:0043025neuronal cell bodyIEA
GO:0043234protein complexISS
GO:0043235receptor complexIDA
Function
IDNameEvidence
GO:0004714transmembrane receptor protein tyrosine kinase activityIDA
GO:0005166neurotrophin p75 receptor bindingIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0010465nerve growth factor receptor activityIDA
GO:0042803protein homodimerization activityIDA
GO:0043121neurotrophin bindingTAS
GO:0046875ephrin receptor bindingIEA
GO:0048406nerve growth factor bindingIDA
GO:0048406nerve growth factor bindingIDA
GeneCards NTRK1
UniProt P04629, X5DR71
Vega OTTHUMG00000041304
MIM 191315
Ensembl ENSG00000198400
HGNC 8031
HPRD 01869

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NTRK1 gene?

The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process is called phosphorylation. The NTRK1 protein is turned on (activated) when another protein called nerve growth factor beta (NGFβ) attaches (binds) to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). Then, the activated NTRK1 protein phosphorylates other proteins; this process is needed to transmit signals for cell growth and survival.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.