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Sequence in raw or FASTA format:


Blast Method:


CISD2 CDGSH iron sulfur domain 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001008388 Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
XM_005263040 PREDICTED: Homo sapiens CDGSH iron sulfur domain 2 (CISD2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $299.00 14

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Gene Symbol CISD2
Entrez Gene ID 493856
Full Name CDGSH iron sulfur domain 2
Synonyms ERIS, Miner1, NAF-1, WFS2, ZCD2
General protein information
Preferred Names
CDGSH iron-sulfur domain-containing protein 2
CDGSH iron-sulfur domain-containing protein 2
mitoNEET related 1
mitoNEET-related 1 protein
zinc finger, CDGSH-type domain 2
nutrient-deprivation autophagy factor-1
endoplasmic reticulum intermembrane small protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011].

MIM: 611507

Wolfram syndrome 2, 604928 (3)

mRNA Protein Product Sequence Price Select
NM_001008388, 300116254 NP_001008389, 56605994 CDGSH iron-sulfur domain-containing protein 2 ORF Sequence $99.00
XM_005263040, 578809156 XP_005263097, 530377783 CDGSH iron-sulfur domain-containing protein 2 isoform X1 ORF Sequence $150.00
Homo sapiens (human)CISD2NP_001008389.1
Pan troglodytes (chimpanzee)CISD2XP_003310469.1
Macaca mulatta (Rhesus monkey)LOC100429989XP_002804204.1
Bos taurus (cattle)CISD2NP_001073807.1
Mus musculus (house mouse)Cisd2NP_080178.1
Rattus norvegicus (Norway rat)Cisd2NP_001178537.1
Gallus gallus (chicken)CISD2XP_420668.1
Danio rerio (zebrafish)cisd2NP_956677.1
Drosophila melanogaster (fruit fly)CG1458NP_651684.1
Xenopus (Silurana) tropicalis (western clawed frog)cisd2NP_001011479.1
GO:0000422mitochondrion degradationIEA
GO:0010259multicellular organismal agingISS
GO:0010506regulation of autophagyIMP
GO:0005741mitochondrial outer membraneISS
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneIDA
GO:0016021integral component of membraneIEA
GO:0043234protein complexIDA
GO:0005515protein bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0044822poly(A) RNA bindingIDA
GO:0046872metal ion bindingIEA
GO:00515372 iron, 2 sulfur cluster bindingIDA
GeneCards CISD2
UniProt Q8N5K1
MIM 611507
HGNC 24212
HPRD 17413

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CISD2 gene?

The CISD2 gene provides instructions for making a protein that is found in the outer membrane of cell structures called mitochondria. Mitochondria are involved in a wide variety of cellular activities, including energy production, chemical signaling, and regulation of cell growth and division. The exact function of the CISD2 protein is unknown, but it is thought to help keep mitochondria functioning normally.


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