Sequence in raw or FASTA format:
CISD2 CDGSH iron sulfur domain 2 [Homo sapiens (human)]
| Gene Symbol | CISD2 |
| Entrez Gene ID | 493856 |
| Full Name | CDGSH iron sulfur domain 2 |
| Synonyms | ERIS, Miner1, NAF-1, WFS2, ZCD2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
4 4q24 |
| Summary | The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq]. |
| Disorder | MIM: 611507 Wolfram syndrome 2, 604928 (3) |
| mRNA | NM_001008388, 300116254 |
| Protein | NP_001008389, 56605994 |
| Product | CDGSH iron-sulfur domain-containing protein 2 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | CISD2 | NP_001008389.1 |
| Canis lupus familiaris (dog) | CISD2 | XP_852575.1 |
| Bos taurus (cattle) | CISD2 | NP_001073807.1 |
| Mus musculus (house mouse) | Cisd2 | NP_080178.1 |
| Rattus norvegicus (Norway rat) | Cisd2 | XP_215704.2 |
| Gallus gallus (chicken) | CISD2 | XP_420668.1 |
| Danio rerio (zebrafish) | cisd2 | NP_956677.1 |
| Drosophila melanogaster (fruit fly) | CG1458 | NP_651684.1 |
| ID | Name | Evidence |
| GO:0000422 | mitochondrion degradation | IEA |
| GO:0010259 | multicellular organismal aging | ISS |
| GO:0010506 | regulation of autophagy | IMP |
Component
| ID | Name | Evidence |
| GO:0005739 | mitochondrion | IEA |
| GO:0005741 | mitochondrial outer membrane | ISS |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005789 | endoplasmic reticulum membrane | IDA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0043234 | protein complex | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0046872 | metal ion binding | IEA |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IDA |
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