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TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23879 NM_002546 Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA. pcDNA3.1+-DYK In-stock 5-7 $149.00
OHu23879C NM_002546 Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol TNFRSF11B
Entrez Gene ID 4982
Full Name tumor necrosis factor receptor superfamily, member 11b
Synonyms OCIF, OPG, TR1
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
tumor necrosis factor receptor superfamily member 11B
osteoprotegerin
osteoclastogenesis inhibitory factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602643

Paget disease, juvenile, 239000 (3)

mRNA Protein Product Sequence Price Select
NM_002546, 148743792 NP_002537, 148743793 tumor necrosis factor receptor superfamily member 11B precursor ORF Sequence $269.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
WikiPathways
WP12Osteoclast Signaling
WP1772Apoptosis Modulation and Signaling
WP322Osteoblast Signaling
WP727Monoamine Transport
WP2018RANKL/RANK Signaling Pathway
Homo sapiens (human)TNFRSF11BNP_002537.3
Pan troglodytes (chimpanzee)TNFRSF11BXP_519921.2
Macaca mulatta (Rhesus monkey)TNFRSF11BXP_001096915.1
Canis lupus familiaris (dog)TNFRSF11BXP_003639496.1
Bos taurus (cattle)TNFRSF11BNP_001091525.1
Mus musculus (house mouse)Tnfrsf11bNP_032790.3
Rattus norvegicus (Norway rat)Tnfrsf11bNP_037002.1
Gallus gallus (chicken)TNFRSF11BNP_001028813.1
Xenopus (Silurana) tropicalis (western clawed frog)tnfrsf11bXP_002938025.2
Process
IDNameEvidence
GO:0001501skeletal system developmentTAS
GO:0006915apoptotic processIEA
GO:0007165signal transductionIEA
GO:0007584response to nutrientIEA
GO:0030198extracellular matrix organizationIEA
GO:0032026response to magnesium ionIEA
GO:0042489negative regulation of odontogenesis of dentin-containing toothIEA
GO:0042493response to drugIEA
GO:0043627response to estrogenIEA
GO:0045779negative regulation of bone resorptionIEA
GO:0046685response to arsenic-containing substanceIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceIDA
Function
IDNameEvidence
GO:0004872receptor activityTAS
GO:0005125cytokine activityTAS
GeneCards TNFRSF11B
PDB 3URF
UniProt O00300
Vega OTTHUMG00000164969
MIM 602643
Ensembl ENSG00000164761
HGNC 11909
HPRD 04032

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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