• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002546 Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

Related Services

Gene Symbol TNFRSF11B
Entrez Gene ID 4982
Full Name tumor necrosis factor receptor superfamily, member 11b
Synonyms OCIF, OPG, TR1
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 11B
tumor necrosis factor receptor superfamily member 11B
osteoclastogenesis inhibitory factor
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].

MIM: 602643

Paget disease, juvenile, 239000 (3)

mRNA Protein Product Sequence Price Select
NM_002546, 148743792 NP_002537, 148743793 tumor necrosis factor receptor superfamily member 11B precursor ORF Sequence $269.00
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
WP12Osteoclast Signaling
WP1772Apoptosis Modulation and Signaling
WP322Osteoblast Signaling
WP727Monoamine Transport
WP2018RANKL/RANK Signaling Pathway
Homo sapiens (human)TNFRSF11BNP_002537.3
Pan troglodytes (chimpanzee)TNFRSF11BXP_519921.2
Macaca mulatta (Rhesus monkey)TNFRSF11BXP_001096915.1
Canis lupus familiaris (dog)TNFRSF11BXP_003639496.1
Bos taurus (cattle)TNFRSF11BNP_001091525.1
Mus musculus (house mouse)Tnfrsf11bNP_032790.3
Rattus norvegicus (Norway rat)Tnfrsf11bNP_037002.1
Gallus gallus (chicken)TNFRSF11BNP_001028813.1
Xenopus (Silurana) tropicalis (western clawed frog)tnfrsf11bXP_002938025.2
GO:0001501skeletal system developmentTAS
GO:0006915apoptotic processIEA
GO:0007165signal transductionIEA
GO:0007584response to nutrientIEA
GO:0030198extracellular matrix organizationIEA
GO:0032026response to magnesium ionIEA
GO:0042489negative regulation of odontogenesis of dentin-containing toothIEA
GO:0042493response to drugIEA
GO:0043627response to estrogenIEA
GO:0045779negative regulation of bone resorptionIEA
GO:0046685response to arsenic-containing substanceIEA
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceIDA
GO:0004872receptor activityTAS
GO:0005125cytokine activityTAS
GeneCards TNFRSF11B
UniProt O00300
Vega OTTHUMG00000164969
MIM 602643
Ensembl ENSG00000164761
HGNC 11909
HPRD 04032

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TNFRSF11B gene?

The TNFRSF11B gene provides instructions for making a protein called osteoprotegerin. This protein plays an important role in bone remodeling, a normal process in which old bone is broken down and new bone is created to replace it. Osteoprotegerin is involved in the regulation of specialized cells called osteoclasts, which break down bone tissue during bone remodeling.

Osteoprotegerin is one of two receptor proteins that can attach (bind) to a protein called receptor activator of NF-κB ligand (RANKL). The other receptor protein is called receptor activator of NF-κB (RANK). Because RANKL can only bind to one receptor at a time, osteoprotegerin and RANK compete with one another. When RANKL is bound to RANK, it sets off a series of chemical signals that trigger immature osteoclasts to mature and become fully functional. When RANKL is bound to osteoprotegerin, it blocks these chemical signals and prevents the activation of osteoclasts. Because no chemical signals are transmitted when RANKL is attached to osteoprotegerin, osteoprotegerin is often called a "decoy" receptor.

By reducing the amount of RANKL that is available to bind to RANK, osteoprotegerin plays a critical role in regulating the process of bone remodeling.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.