Sequence in raw or FASTA format:
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [Homo sapiens (human)]
|Entrez Gene ID||4982|
|Full Name||tumor necrosis factor receptor superfamily, member 11b|
|Synonyms||OCIF, OPG, TR1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].|
Paget disease, juvenile, 239000 (3)
|hsa04060||Cytokine-cytokine receptor interaction|
|WP1772||Apoptosis Modulation and Signaling|
|WP2018||RANKL/RANK Signaling Pathway|
|Homo sapiens (human)||TNFRSF11B||NP_002537.3|
|Pan troglodytes (chimpanzee)||TNFRSF11B||XP_519921.2|
|Macaca mulatta (Rhesus monkey)||TNFRSF11B||XP_001096915.1|
|Canis lupus familiaris (dog)||TNFRSF11B||XP_003639496.1|
|Bos taurus (cattle)||TNFRSF11B||NP_001091525.1|
|Mus musculus (house mouse)||Tnfrsf11b||NP_032790.3|
|Rattus norvegicus (Norway rat)||Tnfrsf11b||NP_037002.1|
|Gallus gallus (chicken)||TNFRSF11B||NP_001028813.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||tnfrsf11b||XP_002938025.2|
|GO:0001501||skeletal system development||TAS|
|GO:0007584||response to nutrient||IEA|
|GO:0030198||extracellular matrix organization||IEA|
|GO:0032026||response to magnesium ion||IEA|
|GO:0042489||negative regulation of odontogenesis of dentin-containing tooth||IEA|
|GO:0042493||response to drug||IEA|
|GO:0043627||response to estrogen||IEA|
|GO:0045779||negative regulation of bone resorption||IEA|
|GO:0046685||response to arsenic-containing substance||IEA|
|GO:0005578||proteinaceous extracellular matrix||IEA|
What is the normal function of the TNFRSF11B gene?
The TNFRSF11B gene provides instructions for making a protein called osteoprotegerin. This protein plays an important role in bone remodeling, a normal process in which old bone is broken down and new bone is created to replace it. Osteoprotegerin is involved in the regulation of specialized cells called osteoclasts, which break down bone tissue during bone remodeling.
Osteoprotegerin is one of two receptor proteins that can attach (bind) to a protein called receptor activator of NF-κB ligand (RANKL). The other receptor protein is called receptor activator of NF-κB (RANK). Because RANKL can only bind to one receptor at a time, osteoprotegerin and RANK compete with one another. When RANKL is bound to RANK, it sets off a series of chemical signals that trigger immature osteoclasts to mature and become fully functional. When RANKL is bound to osteoprotegerin, it blocks these chemical signals and prevents the activation of osteoclasts. Because no chemical signals are transmitted when RANKL is attached to osteoprotegerin, osteoprotegerin is often called a "decoy" receptor.
By reducing the amount of RANKL that is available to bind to RANK, osteoprotegerin plays a critical role in regulating the process of bone remodeling.
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