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OTX2 orthodenticle homeobox 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16734 NM_001270525 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 5, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16734 NM_021728 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16931 NM_172337 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu16931 NM_001270524 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu16931 NM_001270523 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu16734C NM_001270525 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 5, mRNA. Customized vector In-stock 5-7 $149.00
OHu16734C NM_021728 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu16931C NM_172337 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu16931C NM_001270524 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu16931C NM_001270523 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 3, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol OTX2
Entrez Gene ID 5015
Full Name orthodenticle homeobox 2
Synonyms CPHD6, MCOPS5
General protein information
Preferred Names
homeobox protein OTX2
Names
homeobox protein OTX2
orthodenticle homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q22.3

Summary This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012].
Disorder

MIM: 600037

Microphthalmia, syndromic 5, 610125 (3)

mRNA Protein Product Sequence Price Select
NM_001270523, 395455070 NP_001257452, 395455071 homeobox protein OTX2 isoform b ORF Sequence $300.00
NM_001270524, 395455072 NP_001257453, 395455073 homeobox protein OTX2 isoform b ORF Sequence $300.00
NM_001270525, 395455074 NP_001257454, 395455075 homeobox protein OTX2 isoform a ORF Sequence $199.00
NM_021728, 395455068 NP_068374, 11119420 homeobox protein OTX2 isoform a ORF Sequence $199.00
NM_172337, 395455069 NP_758840, 27436933 homeobox protein OTX2 isoform b ORF Sequence $300.00
WikiPathways
WP1742TP53 network
Homo sapiens (human)OTX2NP_068374.1
Pan troglodytes (chimpanzee)OTX2XP_001163043.2
Canis lupus familiaris (dog)OTX2XP_003435187.1
Bos taurus (cattle)OTX2NP_001180130.1
Mus musculus (house mouse)Otx2NP_001273410.1
Rattus norvegicus (Norway rat)LOC100911492XP_006251897.1
Danio rerio (zebrafish)otx2NP_571326.1
Process
IDNameEvidence
GO:0001708cell fate specificationIEA
GO:0006461protein complex assemblyIDA
GO:0007411axon guidanceIDA
GO:0007492endoderm developmentIEA
GO:0008589regulation of smoothened signaling pathwayTAS
GO:0009953dorsal/ventral pattern formationIEA
GO:0022037metencephalon developmentIEA
GO:0030900forebrain developmentTAS
GO:0030901midbrain developmentTAS
GO:0032525somite rostral/caudal axis specificationIEA
GO:0040019positive regulation of embryonic developmentISS
GO:0040036regulation of fibroblast growth factor receptor signaling pathwayTAS
GO:0042472inner ear morphogenesisIEA
GO:0042706eye photoreceptor cell fate commitmentIEA
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048852diencephalon morphogenesisIEA
GO:0090009primitive streak formationISS
GO:2000543positive regulation of gastrulationISS
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005737cytoplasmIEA
GO:0030426growth coneIDA
GO:0043234protein complexIDA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0005515protein bindingIPI
GO:0008190eukaryotic initiation factor 4E bindingTAS
GO:0046982protein heterodimerization activityIEA
GeneCards OTX2
UniProt F1T0D0, P32243, F1T0C9, F1T0D1
Vega OTTHUMG00000152338
MIM 600037
Ensembl ENSG00000165588
HGNC 8522
HPRD 07190

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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