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Sequence in raw or FASTA format:

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OXCT1 3-oxoacid CoA transferase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000436 Homo sapiens 3-oxoacid CoA transferase 1 (OXCT1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol OXCT1
Entrez Gene ID 5019
Full Name 3-oxoacid CoA transferase 1
Synonyms OXCT, SCOT
General protein information
Preferred Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
SCOT-s
3-oxoacid CoA-transferase 1
3-oxoacid-CoA transferase 1
succinyl CoA:3-oxoacid CoA transferase
succinyl-CoA:3-ketoacid-CoA transferase
somatic-type succinyl CoA:3-oxoacid CoA-transferase
somatic-type succinyl-CoA:3-oxoacid CoA-transferase
somatic-type succinyl-CoA:3-oxoacid-CoA-transferase
succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
NP_000427.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5p13.1

Summary This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601424

Succinyl CoA:3-oxoacid CoA transferase deficiency, 245050 (3)

mRNA Protein Product Sequence Price Select
NM_000436, 112382246 NP_000427, 4557817 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor ORF Sequence $360.00
KEGG
hsa00072Synthesis and degradation of ketone bodies
hsa00650Butanoate metabolism
hsa00280Valine, leucine and isoleucine degradation
WikiPathways
WP311Synthesis and Degradation of Ketone Bodies
BIOCYC
HUMAN_PWY66-368ketolysis
META_PWY66-368ketolysis
Reactome
REACT_59Utilization of Ketone Bodies
REACT_1861Ketone body metabolism
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
Homo sapiens (human)OXCT1NP_000427.1
Pan troglodytes (chimpanzee)OXCT1XP_001137948.1
Macaca mulatta (Rhesus monkey)OXCT1XP_001114587.1
Canis lupus familiaris (dog)OXCT1XP_536487.2
Bos taurus (cattle)OXCT1NP_001069538.1
Mus musculus (house mouse)Oxct1NP_077150.1
Rattus norvegicus (Norway rat)Oxct1NP_001121052.1
Gallus gallus (chicken)OXCT1NP_001006578.2
Danio rerio (zebrafish)oxct1aNP_001007292.1
Danio rerio (zebrafish)oxct1bNP_001070618.1
Drosophila melanogaster (fruit fly)CG1140NP_647683.1
Caenorhabditis elegansC05C10.3NP_496144.1
Xenopus (Silurana) tropicalis (western clawed frog)oxct1NP_001007927.1
Process
IDNameEvidence
GO:0007420brain developmentIEA
GO:0007507heart developmentIEA
GO:0007584response to nutrientIEA
GO:0009725response to hormoneIEA
GO:0014823response to activityIEA
GO:0032024positive regulation of insulin secretionIEA
GO:0042182ketone catabolic processIEA
GO:0042493response to drugIEA
GO:0042594response to starvationIEA
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045471response to ethanolIEA
GO:0046950cellular ketone body metabolic processIMP
GO:0046950cellular ketone body metabolic processTAS
GO:0046952ketone body catabolic processTAS
GO:0060612adipose tissue developmentIEA
GO:0071229cellular response to acidIEA
GO:0071333cellular response to glucose stimulusIEA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005739mitochondrionNAS
GO:0005759mitochondrial matrixTAS
Function
IDNameEvidence
GO:00082603-oxoacid CoA-transferase activityIMP
GO:00082603-oxoacid CoA-transferase activityTAS
GO:0042803protein homodimerization activityNAS
GeneCards OXCT1
PDB 3DLX
UniProt P55809
Vega OTTHUMG00000094783
MIM 601424
Ensembl ENSG00000083720
HGNC 8527
HPRD 02001

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the OXCT1 gene?

The OXCT1 gene provides instruction for making an enzyme called succinyl-CoA:3-ketoacid CoA transferase, often abbreviated as SCOT. The SCOT enzyme is made in the energy-producing centers of cells (mitochondria). The enzyme plays a role in the breakdown of ketones, which are molecules produced by the liver during the breakdown of fats. Ketones are an important source of energy during prolonged periods without food (fasting) or when energy demands are increased, such as during illness or when exercising. In the processing of ketones, the SCOT enzyme converts the molecule acetoacetate to acetoacetyl-CoA.

Interactant

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