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SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000602 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA. ORF Sequence $350.61
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Gene Symbol SERPINE1
Entrez Gene ID 5054
Full Name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Synonyms PAI, PAI-1, PAI1, PLANH1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q21.3-q22

Summary This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Disorder

MIM: 173360

Plasminogen activator inhibitor, type I, 613329 (3); {Transcription

mRNA Protein Product Sequence Price Select
NM_000602, 383286745 NP_000593, 10835159 plasminogen activator inhibitor 1 isoform 1 precursor Full Length $1122.45
ORF Sequence $350.61
KEGG
hsa04066HIF-1 signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04115p53 signaling pathway
hsa04610Complement and coagulation cascades
WikiPathways
WP560TGF Beta Signaling Pathway
WP558Complement and Coagulation Cascades
WP272Blood Clotting Cascade
WP2374Oncostatin M Signaling Pathway
WP615Senescence and Autophagy
WP15Selenium Pathway
WP236Adipogenesis
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hif2pathwayHIF-2-alpha transcription factor network
p53downstreampathwayDirect p53 effectors
e2f_pathwayE2F transcription factor network
Reactome
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_798Platelet activation, signaling and aggregation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_24941Circadian Clock
REACT_318Platelet degranulation
REACT_111102Signal Transduction
REACT_111118BMAL1:CLOCK/NPAS2 Activates Circadian Expression
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_12627Generic Transcription Pathway
REACT_641Dissolution of Fibrin Clot
REACT_71Gene Expression
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_604Hemostasis
Homo sapiens (human)SERPINE1NP_000593.1
Pan troglodytes (chimpanzee)SERPINE1XP_527841.3
Macaca mulatta (Rhesus monkey)SERPINE1XP_001107647.1
Canis lupus familiaris (dog)SERPINE1NP_001184024.1
Bos taurus (cattle)SERPINE1NP_776562.1
Mus musculus (house mouse)Serpine1NP_032897.2
Rattus norvegicus (Norway rat)Serpine1NP_036752.1
Danio rerio (zebrafish)serpine1NP_001108031.1
GeneCards SERPINE1
PDB 9PAI, 4AQH, 3Q03, 1A7C, 1OC0, 1DB2, 1DVM, 1B3K, 1DVN, 3PB1, 3UT3, 1C5G, 1LJ5, 3CVM, 3EOX, 3R4L, 3Q02
UniProt P05121
MIM 173360
Ensembl ENSG00000106366
HGNC 8583
HPRD 01418

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
plasminogen activator inhibitor 1
Names
plasminogen activator inhibitor 1
serpin E1
endothelial plasminogen activator inhibitor
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Interactant

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