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SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000602 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol SERPINE1
Entrez Gene ID 5054
Full Name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Synonyms PAI, PAI-1, PAI1, PLANH1
General protein information
Preferred Names
plasminogen activator inhibitor 1
Names
plasminogen activator inhibitor 1
serpin E1
endothelial plasminogen activator inhibitor
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22.1

Summary This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Disorder

MIM: 173360

Plasminogen activator inhibitor, type I, 613329 (3); {Transcription

mRNA Protein Product Sequence Price Select
NM_000602, 383286745 NP_000593, 10835159 plasminogen activator inhibitor 1 precursor ORF Sequence $269.00
KEGG
hsa04115p53 signaling pathway
hsa04610Complement and coagulation cascades
hsa05142Chagas disease (American trypanosomiasis)
hsa04066HIF-1 signaling pathway
hsa04390Hippo signaling pathway
WikiPathways
WP615Senescence and Autophagy
WP560TGF Beta Signaling Pathway
WP15Selenium Pathway
WP272Blood Clotting Cascade
WP236Adipogenesis
WP2374Oncostatin M Signaling Pathway
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hif2pathwayHIF-2-alpha transcription factor network
e2f_pathwayE2F transcription factor network
hif1_tfpathwayHIF-1-alpha transcription factor network
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_641Dissolution of Fibrin Clot
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_24941Circadian Clock
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_111102Signal Transduction
REACT_116125Disease
REACT_118779Extracellular matrix organization
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_163906ECM proteoglycans
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
Homo sapiens (human)SERPINE1NP_000593.1
Pan troglodytes (chimpanzee)SERPINE1XP_527841.3
Macaca mulatta (Rhesus monkey)SERPINE1XP_001107647.1
Canis lupus familiaris (dog)SERPINE1NP_001184024.1
Bos taurus (cattle)SERPINE1NP_776562.1
Mus musculus (house mouse)Serpine1NP_032897.2
Rattus norvegicus (Norway rat)Serpine1NP_036752.1
Danio rerio (zebrafish)serpine1NP_001108031.1
Xenopus (Silurana) tropicalis (western clawed frog)serpine1XP_002941247.2
Process
IDNameEvidence
GO:0001300chronological cell agingIEP
GO:0001525angiogenesisIEP
GO:0002576platelet degranulationTAS
GO:0006351transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007179transforming growth factor beta receptor signaling pathwayTAS
GO:0007596blood coagulationTAS
GO:0010467gene expressionTAS
GO:0010469regulation of receptor activityIDA
GO:0010757negative regulation of plasminogen activationIDA
GO:0010757negative regulation of plasminogen activationIMP
GO:0010951negative regulation of endopeptidase activityIDA
GO:0014912negative regulation of smooth muscle cell migrationIDA
GO:0030168platelet activationTAS
GO:0030194positive regulation of blood coagulationIMP
GO:0030195negative regulation of blood coagulationIC
GO:0030198extracellular matrix organizationTAS
GO:0030336negative regulation of cell migrationIDA
GO:0032757positive regulation of interleukin-8 productionIMP
GO:0033629negative regulation of cell adhesion mediated by integrinIDA
GO:0035491positive regulation of leukotriene production involved in inflammatory responseIMP
GO:0042127regulation of cell proliferationIEA
GO:0042730fibrinolysisTAS
GO:0045766positive regulation of angiogenesisIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS
GO:0048260positive regulation of receptor-mediated endocytosisIDA
GO:0050729positive regulation of inflammatory responseIGI
GO:0050829defense response to Gram-negative bacteriumIGI
GO:0051918negative regulation of fibrinolysisIDA
GO:0061044negative regulation of vascular wound healingIGI
GO:0061045negative regulation of wound healingIC
GO:0071222cellular response to lipopolysaccharideIMP
GO:0090026positive regulation of monocyte chemotaxisIMP
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMP
GO:2000098negative regulation of smooth muscle cell-matrix adhesionIDA
GO:2000352negative regulation of endothelial cell apoptotic processIMP
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0031012extracellular matrixIDA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0002020protease bindingIPI
GO:0004867serine-type endopeptidase inhibitor activityIDA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GeneCards SERPINE1
UniProt P05121
Vega OTTHUMG00000157107
MIM 173360
Ensembl ENSG00000106366
HGNC 8583
HPRD 01418

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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