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Sequence in raw or FASTA format:

Database:

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PAX6 paired box 6 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20414 NM_001258465 Homo sapiens paired box 6 (PAX6), transcript variant 7, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20729 NM_001258462 Homo sapiens paired box 6 (PAX6), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20729 NM_001604 Homo sapiens paired box 6 (PAX6), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20414 NM_001258464 Homo sapiens paired box 6 (PAX6), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20414 NM_000280 Homo sapiens paired box 6 (PAX6), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20729 NM_001258463 Homo sapiens paired box 6 (PAX6), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20414 NM_001127612 Homo sapiens paired box 6 (PAX6), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20729 XM_005252954 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20414 XM_005252955 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20414 XM_005252956 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu44887 XM_005252957 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu44888 XM_006718244 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu44889 XM_006718245 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu44890 XM_006718246 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X8, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu44891 XM_005252958 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu20414C NM_001258465 Homo sapiens paired box 6 (PAX6), transcript variant 7, mRNA. Customized vector On-demand 7-9 $269.00
OHu20729C NM_001258462 Homo sapiens paired box 6 (PAX6), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu20729C NM_001604 Homo sapiens paired box 6 (PAX6), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu20414C NM_001258464 Homo sapiens paired box 6 (PAX6), transcript variant 6, mRNA. Customized vector On-demand 7-9 $269.00
OHu20414C NM_000280 Homo sapiens paired box 6 (PAX6), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu20729C NM_001258463 Homo sapiens paired box 6 (PAX6), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu20414C NM_001127612 Homo sapiens paired box 6 (PAX6), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu20729C XM_005252954 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu20414C XM_005252955 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu20414C XM_005252956 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu44887C XM_005252957 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X4, mRNA. Customized vector On-demand 7-9 $269.00
OHu44888C XM_006718244 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X6, mRNA. Customized vector On-demand 7-9 $269.00
OHu44889C XM_006718245 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X7, mRNA. Customized vector On-demand 7-9 $269.00
OHu44890C XM_006718246 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X8, mRNA. Customized vector On-demand 7-9 $269.00
OHu44891C XM_005252958 PREDICTED: Homo sapiens paired box 6 (PAX6), transcript variant X5, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol PAX6
Entrez Gene ID 5080
Full Name paired box 6
Synonyms AN, AN2, D11S812E, MGDA, WAGR
General protein information
Preferred Names
paired box protein Pax-6
Names
paired box protein Pax-6
oculorhombin
aniridia type II protein
paired box homeotic gene-6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p13

Summary This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Disorder

MIM: 607108

Aniridia, 106210 (3); Peters anomaly, 604229 (3); Cataract with

mRNA Protein Product Sequence Price Select
NM_000280, 386642908 NP_000271, 4505615 paired box protein Pax-6 isoform a ORF Sequence $550.00
NM_001127612, 189083680 NP_001121084, 189083681 paired box protein Pax-6 isoform a ORF Sequence $550.00
NM_001258462, 386642910 NP_001245391, 386642911 paired box protein Pax-6 isoform b ORF Sequence $550.00
NM_001258463, 386642912 NP_001245392, 386642913 paired box protein Pax-6 isoform b ORF Sequence $550.00
NM_001258464, 386642914 NP_001245393, 386642915 paired box protein Pax-6 isoform a ORF Sequence $550.00
NM_001258465, 386642916 NP_001245394, 386642917 paired box protein Pax-6 isoform a ORF Sequence $550.00
NM_001604, 386642909 NP_001595, 4580424 paired box protein Pax-6 isoform b ORF Sequence $550.00
XM_005252954, 578820579 XP_005253011, 530395426 paired box protein Pax-6 isoform X1 ORF Sequence $550.00
XM_005252955, 578820580 XP_005253012, 530395428 paired box protein Pax-6 isoform X2 ORF Sequence $550.00
XM_005252956, 578820581 XP_005253013, 530395430 paired box protein Pax-6 isoform X3 ORF Sequence $550.00
XM_005252957, 530395431 XP_005253014, 530395432 paired box protein Pax-6 isoform X4 ORF Sequence $400.00
XM_005252958, 578820588 XP_005253015, 530395434 paired box protein Pax-6 isoform X5 ORF Sequence $300.00
XM_006718244, 578820582 XP_006718307, 578820583 paired box protein Pax-6 isoform X6 ORF Sequence $400.00
XM_006718245, 578820584 XP_006718308, 578820585 paired box protein Pax-6 isoform X7 ORF Sequence $400.00
XM_006718246, 578820586 XP_006718309, 578820587 paired box protein Pax-6 isoform X8 ORF Sequence $400.00
KEGG
hsa04950Maturity onset diabetes of the young
WikiPathways
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
cdc42_pathwayCDC42 signaling events
Reactome
REACT_17015Metabolism of proteins
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23824Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_111045Developmental Biology
REACT_160078Peptide hormone metabolism
Homo sapiens (human)PAX6NP_001595.2
Pan troglodytes (chimpanzee)PAX6XP_003954413.1
Macaca mulatta (Rhesus monkey)PAX6XP_001084865.2
Bos taurus (cattle)PAX6NP_001035735.1
Mus musculus (house mouse)Pax6NP_001231127.1
Rattus norvegicus (Norway rat)Pax6NP_037133.1
Gallus gallus (chicken)PAX6NP_990397.1
Danio rerio (zebrafish)pax6aNP_571379.1
Drosophila melanogaster (fruit fly)toyNP_524638.3
Caenorhabditis elegansvab-3NP_001024570.1
Xenopus (Silurana) tropicalis (western clawed frog)pax6NP_001006763.1
Process
IDNameEvidence
GO:0001568blood vessel developmentIMP
GO:0001654eye developmentTAS
GO:0001709cell fate determinationIEA
GO:0001764neuron migrationIEA
GO:0002052positive regulation of neuroblast proliferationIEA
GO:0002088lens development in camera-type eyeIEA
GO:0003309type B pancreatic cell differentiationIEA
GO:0003322pancreatic A cell developmentIMP
GO:0006366transcription from RNA polymerase II promoterIMP
GO:0007224smoothened signaling pathwayIEA
GO:0007411axon guidanceIEA
GO:0007417central nervous system developmentTAS
GO:0007435salivary gland morphogenesisIEA
GO:0007601visual perceptionTAS
GO:0009611response to woundingIEP
GO:0009887organ morphogenesisTAS
GO:0009950dorsal/ventral axis specificationIEA
GO:0010628positive regulation of gene expressionIMP
GO:0016567protein ubiquitinationISS
GO:0021778oligodendrocyte cell fate specificationIEA
GO:0021796cerebral cortex regionalizationIEA
GO:0021797forebrain anterior/posterior pattern specificationIEA
GO:0021798forebrain dorsal/ventral pattern formationIEA
GO:0021902commitment of neuronal cell to specific neuron type in forebrainIEA
GO:0021905forebrain-midbrain boundary formationIEA
GO:0021912regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specificationIEA
GO:0021913regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specificationIEA
GO:0021918regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitmentIEA
GO:0021983pituitary gland developmentIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030216keratinocyte differentiationIEA
GO:0030334regulation of cell migrationIEA
GO:0030858positive regulation of epithelial cell differentiationIEA
GO:0030902hindbrain developmentIEA
GO:0032808lacrimal gland developmentIEA
GO:0033365protein localization to organelleIEA
GO:0042462eye photoreceptor cell developmentIEA
GO:0042593glucose homeostasisIMP
GO:0042660positive regulation of cell fate specificationIEA
GO:0045665negative regulation of neuron differentiationIEA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0048505regulation of timing of cell differentiationIEA
GO:0048596embryonic camera-type eye morphogenesisIEA
GO:0048663neuron fate commitmentNAS
GO:0048708astrocyte differentiationIEA
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0050768negative regulation of neurogenesisISS
GO:0061072iris morphogenesisIMP
GO:0061303cornea development in camera-type eyeIMP
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDA
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityIDA
GO:0003677DNA bindingTAS
GO:0003680AT DNA bindingIEA
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0004842ubiquitin-protein transferase activityISS
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingISS
GO:0019901protein kinase bindingISS
GO:0031625ubiquitin protein ligase bindingIEA
GO:0035035histone acetyltransferase bindingISS
GO:0070410co-SMAD bindingIEA
GO:0070412R-SMAD bindingIPI
GO:0071837HMG box domain bindingIEA
GeneCards PAX6
UniProt P26367, F1T0F8, Q66SS1
Vega OTTHUMG00000041447
MIM 607108
Ensembl ENSG00000007372
HGNC 8620
HPRD 06167

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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