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IRAK4 interleukin-1 receptor-associated kinase 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001114182 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001145256 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001145257 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001145258 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_016123 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol IRAK4
Entrez Gene ID 51135
Full Name interleukin-1 receptor-associated kinase 4
Synonyms IPD1, NY-REN-64, REN64
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Disorder

MIM: 606883

IRAK4 deficiency, 607676 (3); Invasive pneumococcal disease,

mRNA Protein Product Sequence Price Select
NM_001114182, 223671880 NP_001107654, 166795295 interleukin-1 receptor-associated kinase 4 isoform a ORF Sequence $550.00
NM_001145256, 223671882 NP_001138728, 223671883 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_001145257, 223671884 NP_001138729, 223671885 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_001145258, 223671887 NP_001138730, 223671888 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_016123, 223671881 NP_057207, 166795293 interleukin-1 receptor-associated kinase 4 isoform a ORF Sequence $550.00
KEGG
hsa05140Leishmaniasis
hsa04064NF-kappa B signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05152Tuberculosis
hsa04722Neurotrophin signaling pathway
hsa05145Toxoplasmosis
hsa04210Apoptosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05164Influenza A
hsa05162Measles
hsa05133Pertussis
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
WikiPathways
WP195IL-1 Signaling Pathway
WP75Toll-like receptor signaling pathway
WP2324AGE/RAGE pathway
Reactome
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_22232Signaling by Interleukins
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6890Activated TLR4 signalling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_75790Cytokine Signaling in Immune system
REACT_22442Interleukin-1 signaling
REACT_6900Immune System
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6966Toll Receptor Cascades
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_25120TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6802Innate Immune System
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Homo sapiens (human)IRAK4NP_001107654.1
Pan troglodytes (chimpanzee)IRAK4XP_001166075.1
Macaca mulatta (Rhesus monkey)IRAK4NP_001129573.1
Canis lupus familiaris (dog)IRAK4XP_543727.1
Bos taurus (cattle)IRAK4NP_001069466.1
Mus musculus (house mouse)Irak4NP_084202.2
Rattus norvegicus (Norway rat)Irak4NP_001100261.2
Gallus gallus (chicken)IRAK4NP_001025909.1
Danio rerio (zebrafish)irak4NP_956457.1
Arabidopsis thaliana (thale cress)APK2ANP_172889.1
Arabidopsis thaliana (thale cress)APK2BNP_178383.1
GeneCards IRAK4
PDB 2OIC, 2O8Y, 3MOP, 2NRY, 2OID, 2NRU, 2OIB
UniProt B4E359, Q69FE3, B2RAP9, Q9NWZ3
MIM 606883
Ensembl ENSG00000198001
HGNC 17967
HPRD 06051

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 4
Names
interleukin-1 receptor-associated kinase 4
renal carcinoma antigen NY-REN-64
NP_001107654.1
NP_001138728.1
NP_001138729.1
NP_001138730.1
NP_057207.2

Interactant



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