IRAK4 interleukin-1 receptor-associated kinase 4 [Homo sapiens (human)]
| Gene Symbol | IRAK4 |
| Entrez Gene ID | 51135 |
| Full Name | interleukin-1 receptor-associated kinase 4 |
| Synonyms | IPD1, NY-REN-64, REN64 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12q12 |
| Summary | This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq]. |
| Disorder | MIM: 606883 IRAK4 deficiency, 607676 (3); Invasive pneumococcal disease, |
| mRNA | NM_001145256, 223671882 |
| Protein | NP_001138728, 223671883 |
| Product | interleukin-1 receptor-associated kinase 4 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_001114182, 223671880 |
| Protein | NP_001107654, 166795295 |
| Product | interleukin-1 receptor-associated kinase 4 isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001145257, 223671884 |
| Protein | NP_001138729, 223671885 |
| Product | interleukin-1 receptor-associated kinase 4 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_016123, 223671881 |
| Protein | NP_057207, 166795293 |
| Product | interleukin-1 receptor-associated kinase 4 isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001145258, 223671887 |
| Protein | NP_001138730, 223671888 |
| Product | interleukin-1 receptor-associated kinase 4 isoform b |
| RefSeq Status | REVIEWED |
| hsa05145 | Toxoplasmosis |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04210 | Apoptosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05140 | Leishmaniasis |
WikiPathways
| WP75 | Toll-like receptor signaling pathway |
| WP195 | IL-1 Signaling Pathway |
Pathway Interaction Database
| il1pathway | IL1-mediated signaling events |
Reactome
| REACT_22442 | Interleukin-1 signaling |
| REACT_6894 | Toll Like Receptor 4 (TLR4) Cascade |
| REACT_6900 | Signaling in Immune system |
| REACT_6966 | Toll Receptor Cascades |
| REACT_6890 | Activated TLR4 signalling |
| REACT_6788 | MyD88:Mal cascade initiated on plasma membrane |
| REACT_9047 | Toll Like Receptor 9 (TLR9) Cascade |
| REACT_7980 | Toll Like Receptor 2 Cascade |
| REACT_25120 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| REACT_8006 | Toll Like Receptor TLR6:TLR2 Cascade |
| REACT_6802 | Innate Immunity Signaling |
| REACT_9020 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REACT_8005 | Toll Like Receptor TLR1:TLR2 Cascade |
| REACT_25024 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REACT_25222 | MyD88 dependent cascade initiated on endosome |
| REACT_22232 | Signaling by Interleukins |
| Homo sapiens (human) | IRAK4 | NP_001107654.1 |
| Pan troglodytes (chimpanzee) | IRAK4 | XP_001166114.1 |
| Canis lupus familiaris (dog) | IRAK4 | XP_543727.1 |
| Bos taurus (cattle) | IRAK4 | NP_001069466.1 |
| Mus musculus (house mouse) | Irak4 | NP_084202.2 |
| Rattus norvegicus (Norway rat) | Irak4 | XP_217026.4 |
| Gallus gallus (chicken) | IRAK4 | NP_001025909.1 |
| Danio rerio (zebrafish) | irak4 | NP_956457.1 |
| Arabidopsis thaliana (thale cress) | APK2B | NP_973403.1 |
| Arabidopsis thaliana (thale cress) | APK2A | NP_172889.1 |
| ID | Name | Evidence |
| GO:0001816 | cytokine production | IEA |
| GO:0002224 | toll-like receptor signaling pathway | TAS |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | EXP |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0007165 | signal transduction | IEA |
| GO:0008063 | Toll signaling pathway | TAS |
| GO:0019221 | cytokine-mediated signaling pathway | IEA |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS |
| GO:0045087 | innate immune response | TAS |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0010008 | endosome membrane | EXP |
| GO:0010008 | endosome membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0000287 | magnesium ion binding | IEA |
| GO:0004672 | protein kinase activity | EXP |
| GO:0004672 | protein kinase activity | TAS |
| GO:0004674 | protein serine/threonine kinase activity | EXP |
| GO:0004674 | protein serine/threonine kinase activity | TAS |
| GO:0005149 | interleukin-1 receptor binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
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