• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


IRAK4 interleukin-1 receptor-associated kinase 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001114182 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001145256 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001145257 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001145258 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_016123 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268943 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268944 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268945 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268946 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268947 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005268948 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005268949 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006719438 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006719439 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006719440 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006719441 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006719442 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006719443 PREDICTED: Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

Related Services

Gene Symbol IRAK4
Entrez Gene ID 51135
Full Name interleukin-1 receptor-associated kinase 4
Synonyms IPD1, IRAK-4, NY-REN-64, REN64
General protein information
Preferred Names
interleukin-1 receptor-associated kinase 4
Names
interleukin-1 receptor-associated kinase 4
renal carcinoma antigen NY-REN-64
NP_001107654.1
NP_001138728.1
NP_001138729.1
NP_001138730.1
NP_057207.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Disorder

MIM: 606883

IRAK4 deficiency, 607676 (3); Invasive pneumococcal disease,

mRNA Protein Product Sequence Price Select
NM_001114182, 223671880 NP_001107654, 166795295 interleukin-1 receptor-associated kinase 4 isoform a ORF Sequence $550.00
NM_001145256, 223671882 NP_001138728, 223671883 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_001145257, 223671884 NP_001138729, 223671885 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_001145258, 223671887 NP_001138730, 223671888 interleukin-1 receptor-associated kinase 4 isoform b ORF Sequence $400.00
NM_016123, 223671881 NP_057207, 166795293 interleukin-1 receptor-associated kinase 4 isoform a ORF Sequence $550.00
XM_005268943, 578823835 XP_005269000, 530400397 interleukin-1 receptor-associated kinase 4 isoform X1 ORF Sequence $550.00
XM_005268944, 578823834 XP_005269001, 530400399 interleukin-1 receptor-associated kinase 4 isoform X2 ORF Sequence $550.00
XM_005268945, 578823833 XP_005269002, 530400401 interleukin-1 receptor-associated kinase 4 isoform X3 ORF Sequence $550.00
XM_005268946, 578823836 XP_005269003, 530400403 interleukin-1 receptor-associated kinase 4 isoform X4 ORF Sequence $550.00
XM_005268947, 578823837 XP_005269004, 530400405 interleukin-1 receptor-associated kinase 4 isoform X5 ORF Sequence $400.00
XM_005268948, 530400406 XP_005269005, 530400407 interleukin-1 receptor-associated kinase 4 isoform X6 ORF Sequence $400.00
XM_005268949, 530400408 XP_005269006, 530400409 interleukin-1 receptor-associated kinase 4 isoform X7 ORF Sequence $400.00
XM_006719438, 578823831 XP_006719501, 578823832 interleukin-1 receptor-associated kinase 4 isoform X8 ORF Sequence $550.00
XM_006719439, 578823838 XP_006719502, 578823839 interleukin-1 receptor-associated kinase 4 isoform X9 ORF Sequence $400.00
XM_006719440, 578823840 XP_006719503, 578823841 interleukin-1 receptor-associated kinase 4 isoform X10 ORF Sequence $300.00
XM_006719441, 578823842 XP_006719504, 578823843 interleukin-1 receptor-associated kinase 4 isoform X11 ORF Sequence $300.00
XM_006719442, 578823844 XP_006719505, 578823845 interleukin-1 receptor-associated kinase 4 isoform X12 ORF Sequence $300.00
XM_006719443, 578823846 XP_006719506, 578823847 interleukin-1 receptor-associated kinase 4 isoform X13 ORF Sequence $300.00
KEGG
hsa04210Apoptosis
hsa04620Toll-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05162Measles
hsa05152Tuberculosis
hsa05164Influenza A
hsa05133Pertussis
hsa04064NF-kappa B signaling pathway
WikiPathways
WP195IL-1 Signaling Pathway
WP75Toll-like receptor signaling pathway
WP2324AGE/RAGE pathway
WP1449Regulation of toll-like receptor signaling pathway
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
Reactome
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6966Toll-Like Receptors Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_22232Signaling by Interleukins
REACT_22442Interleukin-1 signaling
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75790Cytokine Signaling in Immune system
REACT_25120TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Homo sapiens (human)IRAK4NP_001107654.1
Pan troglodytes (chimpanzee)IRAK4XP_001166075.1
Macaca mulatta (Rhesus monkey)IRAK4NP_001129573.1
Canis lupus familiaris (dog)IRAK4XP_543727.1
Bos taurus (cattle)IRAK4NP_001069466.1
Mus musculus (house mouse)Irak4NP_084202.2
Rattus norvegicus (Norway rat)Irak4NP_001100261.2
Gallus gallus (chicken)IRAK4NP_001025909.1
Danio rerio (zebrafish)irak4NP_956457.1
Arabidopsis thaliana (thale cress)APK2BNP_178383.1
Arabidopsis thaliana (thale cress)APK2ANP_172889.1
Xenopus (Silurana) tropicalis (western clawed frog)irak4NP_001116877.1
Process
IDNameEvidence
GO:0001816cytokine productionIEA
GO:0002224toll-like receptor signaling pathwayTAS
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTAS
GO:0006468protein phosphorylationIEA
GO:0007254JNK cascadeIEA
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0034134toll-like receptor 2 signaling pathwayTAS
GO:0034142toll-like receptor 4 signaling pathwayTAS
GO:0034146toll-like receptor 5 signaling pathwayTAS
GO:0034162toll-like receptor 9 signaling pathwayTAS
GO:0034166toll-like receptor 10 signaling pathwayTAS
GO:0038123toll-like receptor TLR1:TLR2 signaling pathwayTAS
GO:0038124toll-like receptor TLR6:TLR2 signaling pathwayTAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIMP
GO:0045087innate immune responseTAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0010008endosome membraneTAS
Function
IDNameEvidence
GO:0000287magnesium ion bindingIEA
GO:0004672protein kinase activityEXP
GO:0004674protein serine/threonine kinase activityEXP
GO:0004674protein serine/threonine kinase activityTAS
GO:0005149interleukin-1 receptor bindingIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GeneCards IRAK4
UniProt B4E359, Q69FE3, B2RAP9, Q9NWZ3
MIM 606883
Ensembl ENSG00000198001
HGNC 17967
HPRD 06051

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the IRAK4 gene?

The IRAK4 gene provides instructions for making a protein that plays an important role in innate immunity, which is the body's early, nonspecific response to foreign invaders (pathogens). The IRAK-4 protein is part of a signaling pathway that is involved in early recognition of pathogens and the initiation of inflammation to fight infection.

In particular, the IRAK-4 protein relays signals from proteins called Toll-like receptors and IL-1 receptor-related proteins. As one of the first lines of defense against infection, Toll-like receptors recognize patterns that are common to many pathogens, rather than recognizing specific pathogens, and stimulate a quick immune response. The IL-1 receptor and related proteins recognize immune system proteins called cytokines that signal the need for an immune response. The resulting signaling pathway triggers inflammation, a nonspecific immune response that helps fight infection.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.