Sequence in raw or FASTA format:
GP6 glycoprotein VI (platelet) [
Homo sapiens (human)]
Gene Symbol GP6
Entrez Gene ID
Full Name glycoprotein VI (platelet)
Synonyms BDPLT11, GPIV, GPVI
General protein information
platelet glycoprotein VI
platelet glycoprotein VI
platelet collagen receptor
Gene Type protein-coding
Homo sapiens (human)
Chromosome:19 Map Location:19q13.4
Summary This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Related articles in PubMed An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b. Coxon CH, et al. PLoS One, 2012. PMID 23185356. The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. Kubisz P, et al. Hematology, 2012 Nov. PMID 23168074. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. Nissinen L, et al. J Biol Chem, 2012 Dec 28. PMID 23132859. Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism. Sokol J, et al. Fertil Steril, 2012 Nov. PMID 22901851. Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. Kotuličová D, et al. Blood Coagul Fibrinolysis, 2012 Sep. PMID 22821001. See all (148) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
analysis of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b
Title: An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b.
Our results, especially higher occurrence of four haplotypes in SPS patients, can support an idea that variability of the GP6 gene may be associated with the platelet hyperaggregability insticky platelet syndrome.
Title: The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke.
Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation.
Title: Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.
GP6 SNPs 1613662-G, 1671153-G and 1654419-A alleles are associated with an increased risk for deep venous thrombosis and sticky platelet syndrome.
Title: Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism.
Reactive oxygen species generation downstream of GPVI or FcgammaRIIa consists of two distinct phases: an initial Syk-independent burst followed by additional Syk-dependent generation.
Title: ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways.
Results support the idea that GP6 gene polymorphism may be associated with platelet hyperaggregability, a possible cause of fetal loss.
Title: Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism.
The GPVI-specific agonist collagen-related peptide or thrombin further increases the number of dimers, thereby providing a feedback mechanism for reinforcing binding to collagen and platelet activation.
Title: Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.
analysis of platelet GPVI, a unique platelet-specific receptor with uses in diagnosis and/or disease prevention [review]
Title: Focusing on plasma glycoprotein VI.
Exposure of platelets to high shear induced a metalloproteinase-dependent GPVI cleavage, producing a ~55-kDa soluble ectodomain fragment & A ~10-kDa platelet-associated tail fragment. This may down-regulate GPVI expression.
Title: Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.
Collagen receptor GPVI is platelet-specific, constitutively expressed, and key regulator of thrombosis. Enhanced surface expression is associated with atherosclerotic diseases such as acute coronary syndrome and ischemic stroke. [review-type article]
Title: Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy.
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