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GP6 glycoprotein VI (platelet) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20368 NM_001083899 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20989 NM_001256017 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu21878 NM_016363 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20368C NM_001083899 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu20989C NM_001256017 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 3, mRNA. Customized vector On-demand 7-9 $209.00
OHu21878C NM_016363 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol GP6
Entrez Gene ID 51206
Full Name glycoprotein VI (platelet)
Synonyms BDPLT11, GPIV, GPVI
General protein information
Preferred Names
platelet glycoprotein VI
Names
platelet glycoprotein VI
glycoprotein 6
platelet collagen receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.4

Summary This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Disorder

MIM: 605546

mRNA Protein Product Sequence Price Select
NM_001083899, 563580291 NP_001077368, 563580292 platelet glycoprotein VI isoform 1 precursor ORF Sequence $700.00
NM_001256017, 563580293 NP_001242946, 563580294 platelet glycoprotein VI isoform 3 precursor ORF Sequence $400.00
NM_016363, 563580295 NP_057447, 563580296 platelet glycoprotein VI isoform 2 precursor ORF Sequence $400.00
KEGG
hsa04512ECM-receptor interaction
hsa04611Platelet activation
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1695GPVI-mediated activation cascade
REACT_1230Platelet Adhesion to exposed collagen
REACT_12051Cell surface interactions at the vascular wall
Homo sapiens (human)GP6NP_001242946.2
Pan troglodytes (chimpanzee)GP6XP_513024.3
Canis lupus familiaris (dog)GP6XP_005616212.1
Mus musculus (house mouse)Gp6NP_001156486.1
Rattus norvegicus (Norway rat)Gp6XP_003748805.2
Process
IDNameEvidence
GO:0007167enzyme linked receptor protein signaling pathwayTAS
GO:0007596blood coagulationTAS
GO:0030168platelet activationNAS
GO:0030168platelet activationTAS
GO:0050900leukocyte migrationTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004872receptor activityTAS
GO:0004888transmembrane signaling receptor activityTAS
GO:0005515protein bindingIPI
GO:0005518collagen bindingTAS
GeneCards GP6
UniProt Q9HCN6
Vega OTTHUMG00000159709
MIM 605546
Ensembl ENSG00000088053
HGNC 14388
HPRD 10406

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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