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GP6 glycoprotein VI (platelet) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001083899 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA. ORF Sequence $540.27
Peptide Services
Antibody Services
Protein Services
NM_001256017 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 3, mRNA. ORF Sequence $280.14
Peptide Services
Antibody Services
Protein Services
NM_016363 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 2, mRNA. ORF Sequence $295.80
Peptide Services
Antibody Services
Protein Services


Gene Symbol GP6
Entrez Gene ID 51206
Full Name glycoprotein VI (platelet)
Synonyms GPIV, GPVI, MGC138168
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.4

Summary This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Disorder

MIM: 605546

mRNA Protein Product Sequence Price Select
NM_001083899, 143770740 NP_001077368, 143770741 platelet glycoprotein VI isoform 1 precursor Full Length $657.72
ORF Sequence $540.27
NM_001256017, 365192547 NP_001242946, 365192548 platelet glycoprotein VI isoform 3 Full Length $640.90
ORF Sequence $280.14
NM_016363, 143770754 NP_057447, 143770755 platelet glycoprotein VI isoform 2 precursor Full Length $656.56
ORF Sequence $295.80
KEGG
hsa04512ECM-receptor interaction
Reactome
REACT_1230Platelet Adhesion to exposed collagen
REACT_798Platelet activation, signaling and aggregation
REACT_12051Cell surface interactions at the vascular wall
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
Homo sapiens (human)GP6NP_057447.4
Pan troglodytes (chimpanzee)GP6XP_513024.3
Canis lupus familiaris (dog)GP6XP_541419.3
Mus musculus (house mouse)Gp6NP_001156486.1
GeneCards GP6
PDB 2GI7
UniProt Q9HCN6
MIM 605546
Ensembl ENSG00000088053
HGNC 14388
HPRD 10406

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
platelet glycoprotein VI
Names
platelet glycoprotein VI
glycoprotein 6
platelet collagen receptor

Interactant

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