Sequence in raw or FASTA format:
GP6 glycoprotein VI (platelet) [Homo sapiens (human)]
| Gene Symbol | GP6 |
| Entrez Gene ID | 51206 |
| Full Name | glycoprotein VI (platelet) |
| Synonyms | GPIV, GPVI, MGC138168 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19q13.4 |
| Summary | Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM]. |
| Disorder | MIM: 605546 |
| mRNA | NM_016363, 143770754 |
| Protein | NP_057447, 143770755 |
| Product | platelet glycoprotein VI isoform 2 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001083899, 143770740 |
| Protein | NP_001077368, 143770741 |
| Product | platelet glycoprotein VI isoform 1 |
| RefSeq Status | VALIDATED |
| hsa04512 | ECM-receptor interaction |
Reactome
| REACT_1230 | Platelet Adhesion to exposed collagen |
| REACT_798 | Platelet Activation |
| REACT_1695 | GPVI-mediated activation cascade |
| REACT_20 | Formation of Platelet plug |
| REACT_12051 | Cell surface interactions at the vascular wall |
| REACT_604 | Hemostasis |
| REACT_622 | Platelet activation triggers |
| REACT_20610 | Collagen adhesion via GPVI |
| Homo sapiens (human) | GP6 | NP_057447.4 |
| Pan troglodytes (chimpanzee) | GP6 | XP_513024.2 |
| Canis lupus familiaris (dog) | GP6 | XP_541419.2 |
| Mus musculus (house mouse) | Gp6 | XP_145298.4 |
| ID | Name | Evidence |
| GO:0007167 | enzyme linked receptor protein signaling pathway | TAS |
| GO:0007596 | blood coagulation | TAS |
| GO:0030168 | platelet activation | NAS |
| GO:0030168 | platelet activation | TAS |
| GO:0050900 | leukocyte migration | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | TAS |
| GO:0004888 | transmembrane receptor activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0005518 | collagen binding | TAS |
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