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PHF21A PHD finger protein 21A [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_016621 Homo sapiens PHD finger protein 21A (PHF21A), transcript variant 2, mRNA. Full Length $3237.30
ORF Sequence $552.45
NM_001101802 Homo sapiens PHD finger protein 21A (PHF21A), transcript variant 1, mRNA. Full Length $3299.40
ORF Sequence $592.47


Gene Symbol PHF21A
Entrez Gene ID 51317
Full Name PHD finger protein 21A
Synonyms BHC80, KIAA1696
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p11.2
Summary The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM].
Disorder

MIM: 608325
mRNA NM_016621, 156546909
Protein NP_057705, 156546910
Product PHD finger protein 21A isoform b
RefSeq Status VALIDATED
mRNA NM_001101802, 156546893
Protein NP_001095272, 156546894
Product PHD finger protein 21A isoform a
RefSeq Status VALIDATED
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
Homo sapiens (human)PHF21ANP_057705.3
Pan troglodytes (chimpanzee)PHF21AXP_001161944.1
Canis lupus familiaris (dog)PHF21AXP_861897.1
Bos taurus (cattle)PHF21AXP_001251539.1
Rattus norvegicus (Norway rat)RGD1560612XP_342468.2
Gallus gallus (chicken)PHF21AXP_421123.2
Danio rerio (zebrafish)phf21aXP_693915.3
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0007596blood coagulationTAS
GO:0016568chromatin modificationIEA
Component
IDNameEvidence
GO:0000118histone deacetylase complexIDA
GO:0005634nucleusIEA
GO:0005654nucleoplasmEXP
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0008270zinc ion bindingIEA
GO:0046872metal ion bindingIEA
GeneCards PHF21A
PDB 2PUY, 2YQL
UniProt Q96BD5
MIM 608325
Ensembl ENSG00000135365
HGNC 24156

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