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PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001040633 Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant c, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_016203 Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant a, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_024429 Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant b, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005250002 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005250003 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005250004 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005250005 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005250006 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005250007 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005250009 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006716021 PREDICTED: Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol PRKAG2
Entrez Gene ID 51422
Full Name protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms AAKG, AAKG2, CMH6, H91620p, WPWS
General protein information
Preferred Names
5'-AMP-activated protein kinase subunit gamma-2
Names
5'-AMP-activated protein kinase subunit gamma-2
AMPK subunit gamma-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q36.1

Summary AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602743

Wolff-Parkinson-White syndrome, 194200 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_001040633, 100913191 NP_001035723, 100913192 5'-AMP-activated protein kinase subunit gamma-2 isoform c ORF Sequence $550.00
NM_016203, 100913190 NP_057287, 33186925 5'-AMP-activated protein kinase subunit gamma-2 isoform a ORF Sequence $700.00
NM_024429, 100913188 NP_077747, 100913189 5'-AMP-activated protein kinase subunit gamma-2 isoform b ORF Sequence $269.00
XM_005250002, 530387013 XP_005250059, 530387014 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 ORF Sequence $700.00
XM_005250003, 530387015 XP_005250060, 530387016 5'-AMP-activated protein kinase subunit gamma-2 isoform X2 ORF Sequence $700.00
XM_005250004, 530387017 XP_005250061, 530387018 5'-AMP-activated protein kinase subunit gamma-2 isoform X3 ORF Sequence $700.00
XM_005250005, 530387019 XP_005250062, 530387020 5'-AMP-activated protein kinase subunit gamma-2 isoform X4 ORF Sequence $700.00
XM_005250006, 578814334 XP_005250063, 530387022 5'-AMP-activated protein kinase subunit gamma-2 isoform X5 ORF Sequence $550.00
XM_005250007, 578814335 XP_005250064, 530387024 5'-AMP-activated protein kinase subunit gamma-2 isoform X6 ORF Sequence $550.00
XM_005250009, 530387027 XP_005250066, 530387028 5'-AMP-activated protein kinase subunit gamma-2 isoform X8 ORF Sequence $400.00
XM_006716021, 578814332 XP_006716084, 578814333 5'-AMP-activated protein kinase subunit gamma-2 isoform X9 ORF Sequence $700.00
KEGG
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04710Circadian rhythm
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04921Oxytocin signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
WikiPathways
WP1471TOR signaling
WP1403AMPK signaling
WP1541Energy Metabolism
Reactome
REACT_11082Import of palmitoyl-CoA into the mitochondrial matrix
REACT_1988AMPK inhibits chREBP transcriptional activation activity
REACT_11123Membrane Trafficking
REACT_1505Integration of energy metabolism
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_456PKB-mediated events
REACT_6838mTOR signalling
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_21393Regulation of Rheb GTPase activity by AMPK
REACT_21285Regulation of AMPK activity via LKB1
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
REACT_200751Organelle biogenesis and maintenance
REACT_200686Activation of PPARGC1A (PGC-1alpha) by phosphorylation
REACT_200788Mitochondrial biogenesis
Homo sapiens (human)PRKAG2NP_057287.2
Pan troglodytes (chimpanzee)PRKAG2XP_003318972.1
Canis lupus familiaris (dog)PRKAG2XP_532769.3
Bos taurus (cattle)PRKAG2XP_002687025.2
Mus musculus (house mouse)Prkag2NP_663376.2
Rattus norvegicus (Norway rat)Prkag2NP_908940.1
Gallus gallus (chicken)PRKAG2NP_001265071.1
Danio rerio (zebrafish)prkag2bXP_696730.4
Xenopus (Silurana) tropicalis (western clawed frog)prkag1NP_001121411.1
Process
IDNameEvidence
GO:0005977glycogen metabolic processIMP
GO:0006110regulation of glycolytic processIMP
GO:0006112energy reserve metabolic processTAS
GO:0006469negative regulation of protein kinase activityIDA
GO:0006633fatty acid biosynthetic processIEA
GO:0006754ATP biosynthetic processTAS
GO:0006853carnitine shuttleTAS
GO:0007050cell cycle arrestTAS
GO:0008286insulin receptor signaling pathwayTAS
GO:0010800positive regulation of peptidyl-threonine phosphorylationIMP
GO:0016126sterol biosynthetic processTAS
GO:0019217regulation of fatty acid metabolic processIMP
GO:0035556intracellular signal transductionIMP
GO:0042304regulation of fatty acid biosynthetic processTAS
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045860positive regulation of protein kinase activityIMP
GO:0046320regulation of fatty acid oxidationTAS
GO:0046324regulation of glucose importTAS
GO:0061024membrane organizationTAS
GO:0071901negative regulation of protein serine/threonine kinase activityIDA
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0005654nucleoplasmTAS
GO:0005829cytosolTAS
GO:0031588AMP-activated protein kinase complexIDA
Function
IDNameEvidence
GO:0004862cAMP-dependent protein kinase inhibitor activityIDA
GO:0005524ATP bindingIDA
GO:0008603cAMP-dependent protein kinase regulator activityIMP
GO:0008607phosphorylase kinase regulator activityIMP
GO:0016208AMP bindingIEA
GO:0019901protein kinase bindingIDA
GO:0030295protein kinase activator activityIMP
GO:0043531ADP bindingIDA
GeneCards PRKAG2
UniProt G8JLM0, Q9UGJ0
Vega OTTHUMG00000157324
MIM 602743
Ensembl ENSG00000106617
HGNC 9386
HPRD 04119

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PRKAG2 gene?

The PRKAG2 gene provides instructions for making one part (the gamma-2 subunit) of a larger enzyme called AMP-activated protein kinase (AMPK). This enzyme helps sense and respond to energy demands within cells. It is active in many different tissues, including heart (cardiac) muscle and muscles used for movement (skeletal muscles). AMP-activated protein kinase is likely involved in the development of the heart before birth, although its role in this process is unknown.

AMP-activated protein kinase regulates chemical pathways involving the cell's main energy source, a molecule called adenosine triphosphate (ATP). The breakdown of ATP releases energy to drive many types of chemical reactions. AMP-activated protein kinase is activated during times of cellular stress (such as low oxygen levels or muscle exercise), when ATP is broken down rapidly to produce energy. If ATP levels become too low, the enzyme restores the balance of energy by limiting chemical reactions that require ATP and stimulating pathways that generate ATP.

Studies suggest that AMP-activated protein kinase may play a role in controlling the activity of other genes, although many of these genes have not been identified. The enzyme may also regulate the activity of certain ion channels in the heart. These channels, which transport positively charged atoms (ions) into and out of heart muscle cells, play critical roles in maintaining the heart's normal rhythm.

Interactant

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