PDE4C phosphodiesterase 4C, cAMP-specific [Homo sapiens (human)]
| Gene Symbol | PDE4C |
| Entrez Gene ID | 5143 |
| Full Name | phosphodiesterase 4C, cAMP-specific |
| Synonyms | DPDE1, MGC126222 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.11 |
| Summary | Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4C is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).[supplied by OMIM]. |
| Disorder | MIM: 600128 |
| mRNA | NM_000923, 149363691 |
| Protein | NP_000914, 115529445 |
| Product | cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C-1 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001098818, 149363645 |
| Protein | NP_001092288, 149363646 |
| Product | cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C-3 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001098819, 149363665 |
| Protein | NP_001092289, 149363666 |
| Product | cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C-2 |
| RefSeq Status | VALIDATED |
| hsa00230 | Purine metabolism |
WikiPathways
| WP35 | G Protein Signaling Pathways |
Reactome
| REACT_14797 | Signaling by GPCR |
| REACT_15334 | DARPP-32 events |
| REACT_15295 | Opioid Signalling |
| REACT_19327 | G alpha (s) signalling events |
| REACT_19184 | GPCR downstream signaling |
| Homo sapiens (human) | PDE4C | NP_000914.2 |
| Canis lupus familiaris (dog) | PDE4C | XP_852383.1 |
| Bos taurus (cattle) | PDE4C | XP_602953.4 |
| Mus musculus (house mouse) | Pde4c | NP_963901.1 |
| Rattus norvegicus (Norway rat) | Pde4c | XP_214325.4 |
| Danio rerio (zebrafish) | si:ch211-255d18.1 | XP_002663746.1 |
| ID | Name | Evidence |
| GO:0006198 | cAMP catabolic process | IEA |
| GO:0007165 | signal transduction | IEA |
| GO:0046676 | negative regulation of insulin secretion | IEA |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | EXP |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | TAS |
| GO:0008081 | phosphoric diester hydrolase activity | IEA |
| GO:0008144 | drug binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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