PRRX2 paired related homeobox 2 [Homo sapiens (human)]
| Gene Symbol | PRRX2 |
| Entrez Gene ID | 51450 |
| Full Name | paired related homeobox 2 |
| Synonyms | MGC19843, PMX2, PRX2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9q34.1 |
| Summary | The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 604675 |
| mRNA | NM_016307, 38505203 |
| Protein | NP_057391, 7706659 |
| Product | paired mesoderm homeobox protein 2 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | PRRX2 | NP_057391.1 |
| Pan troglodytes (chimpanzee) | PRRX2 | XP_520310.2 |
| Bos taurus (cattle) | PRRX2 | XP_613967.3 |
| Mus musculus (house mouse) | Prrx2 | NP_033142.1 |
| Rattus norvegicus (Norway rat) | Prrx2 | XP_238327.3 |
| ID | Name | Evidence |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IEA |
| GO:0006351 | transcription, DNA-dependent | NAS |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0030326 | embryonic limb morphogenesis | IEA |
| GO:0042472 | inner ear morphogenesis | IEA |
| GO:0042474 | middle ear morphogenesis | IEA |
| GO:0045880 | positive regulation of smoothened signaling pathway | IEA |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IEA |
| GO:0048844 | artery morphogenesis | IEA |
| GO:0051216 | cartilage development | IEA |
Component
| ID | Name | Evidence |
| GO:0000228 | nuclear chromosome | NAS |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | NAS |
| GO:0043565 | sequence-specific DNA binding | IEA |
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