PDGFRA platelet-derived growth factor receptor, alpha polypeptide [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	PDGFRA
Entrez Gene ID	5156
Full Name	platelet-derived growth factor receptor, alpha polypeptide
Synonyms	CD140A, MGC74795, PDGFR2, RHEPDGFRA
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:4 Map Location:4q12
Summary	This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq].
Disorder	MIM: 173490 Gastrointestinal stromal tumor, somatic, 606764 (3);

mRNA	NM_006206, 172072625
Protein	NP_006197, 5453870
Product	alpha-type platelet-derived growth factor receptor precursor
RefSeq Status	REVIEWED

KEGG

hsa05218	Melanoma
hsa04540	Gap junction
hsa05214	Glioma
hsa04810	Regulation of actin cytoskeleton
hsa04060	Cytokine-cytokine receptor interaction
hsa04144	Endocytosis
hsa05215	Prostate cancer
hsa05200	Pathways in cancer
hsa04020	Calcium signaling pathway
hsa04010	MAPK signaling pathway
hsa04510	Focal adhesion

Pathway Interaction Database

pdgfrapathway	PDGFR-alpha signaling pathway
atf2_pathway	ATF-2 transcription factor network

WikiPathways

WP51	Regulation of Actin Cytoskeleton
WP306	Focal Adhesion
WP322	Osteoblast Signaling

Reactome

REACT_16888	Signaling by PDGF
REACT_17025	Down-stream signal transduction

Homo sapiens (human)	PDGFRA	NP_006197.1
Canis lupus familiaris (dog)	PDGFRA	XP_532374.2
Bos taurus (cattle)	PDGFRA	XP_590921.4
Mus musculus (house mouse)	Pdgfra	NP_001076785.1
Rattus norvegicus (Norway rat)	Pdgfra	XP_214030.2
Gallus gallus (chicken)	PDGFRA	NP_990080.1
Danio rerio (zebrafish)	pdgfra	NP_571534.1

Process

ID	Name	Evidence
GO:0001553	luteinization	ISS
GO:0001701	in utero embryonic development	IEA
GO:0001775	cell activation	TAS
GO:0008210	estrogen metabolic process	IEA
GO:0008284	positive regulation of cell proliferation	IDA
GO:0008585	female gonad development	IEA
GO:0009725	response to hormone stimulus	IEA
GO:0010035	response to inorganic substance	IEA
GO:0018108	peptidyl-tyrosine phosphorylation	IDA
GO:0030198	extracellular matrix organization	IEA
GO:0030324	lung development	IEA
GO:0030325	adrenal gland development	IEA
GO:0030335	positive regulation of cell migration	IDA
GO:0030539	male genitalia development	IEA
GO:0032355	response to estradiol stimulus	IEA
GO:0033327	Leydig cell differentiation	IEA
GO:0034097	response to cytokine stimulus	IEA
GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	IDA
GO:0042060	wound healing	IEA
GO:0042063	gliogenesis	IEA
GO:0042475	odontogenesis of dentine-containing tooth	IEA
GO:0045740	positive regulation of DNA replication	IDA
GO:0046777	protein autophosphorylation	IDA
GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA
GO:0048010	vascular endothelial growth factor receptor signaling pathway	IDA
GO:0048146	positive regulation of fibroblast proliferation	IDA
GO:0048705	skeletal system morphogenesis	IEA
GO:0048839	inner ear development	IEA
GO:0055003	cardiac myofibril assembly	ISS
GO:0055093	response to hyperoxia	IEA
GO:0060021	palate development	IEA
GO:0060325	face morphogenesis	IEA
GO:0061298	retina vasculature development in camera-type eye	ISS
GO:0072277	metanephric glomerular capillary formation	ISS

Component

ID	Name	Evidence
GO:0005634	nucleus	ISS
GO:0005737	cytoplasm	ISS
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	TAS
GO:0005887	integral to plasma membrane	IDA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0004713	protein tyrosine kinase activity	EXP
GO:0004872	receptor activity	IEA
GO:0005018	platelet-derived growth factor alpha-receptor activity	IDA
GO:0005021	vascular endothelial growth factor receptor activity	IDA
GO:0005161	platelet-derived growth factor receptor binding	IPI
GO:0005524	ATP binding	IEA
GO:0019838	growth factor binding	IPI
GO:0042803	protein homodimerization activity	IDA
GO:0043548	phosphatidylinositol 3-kinase binding	IEA
GO:0048407	platelet-derived growth factor binding	IPI

GeneCards	PDGFRA
PDB	1GQ5
UniProt	P16234
MIM	173490
Ensembl	ENSG00000134853
HGNC	8803
HPRD	01429

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RefSeq Accession	Definition	Sequence	Price	Select
NM_006206	Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA.	Full Length	$2958.30
NM_006206		ORF Sequence	$1144.50