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PDGFRA platelet-derived growth factor receptor, alpha polypeptide [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006206 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16
XM_005265743 PREDICTED: Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006714039 PREDICTED: Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006714040 PREDICTED: Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006714041 PREDICTED: Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol PDGFRA
Entrez Gene ID 5156
Full Name platelet-derived growth factor receptor, alpha polypeptide
General protein information
Preferred Names
platelet-derived growth factor receptor alpha
platelet-derived growth factor receptor alpha
CD140a antigen
CD140 antigen-like family member A
platelet-derived growth factor receptor 2
alpha-type platelet-derived growth factor receptor
rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].

MIM: 173490

Gastrointestinal stromal tumor, somatic, 606764 (3);

mRNA Protein Product Sequence Price Select
NM_006206, 172072625 NP_006197, 5453870 platelet-derived growth factor receptor alpha precursor ORF Sequence $999.00
XM_005265743, 530376788 XP_005265800, 530376789 platelet-derived growth factor receptor alpha isoform X1 ORF Sequence $1500.00
XM_006714039, 578808636 XP_006714102, 578808637 platelet-derived growth factor receptor alpha isoform X2 ORF Sequence $1500.00
XM_006714040, 578808638 XP_006714103, 578808639 platelet-derived growth factor receptor alpha isoform X3 ORF Sequence $1500.00
XM_006714041, 578808640 XP_006714104, 578808641 platelet-derived growth factor receptor alpha isoform X4 ORF Sequence $750.00
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04540Gap junction
hsa05166HTLV-I infection
hsa04151PI3K-Akt signaling pathway
hsa05206MicroRNAs in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WP51Regulation of Actin Cytoskeleton
WP322Osteoblast Signaling
WP2377Integrated Pancreatic Cancer Pathway
WP2406Cardiac Progenitor Differentiation
WP2261Signaling Pathways in Glioblastoma
Pathway Interaction Database
pdgfrapathwayPDGFR-alpha signaling pathway
atf2_pathwayATF-2 transcription factor network
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)PDGFRANP_006197.1
Pan troglodytes (chimpanzee)PDGFRAXP_003950404.1
Macaca mulatta (Rhesus monkey)PDGFRAXP_002808459.1
Canis lupus familiaris (dog)PDGFRAXP_005628252.1
Bos taurus (cattle)PDGFRANP_001179274.1
Mus musculus (house mouse)PdgfraNP_001076785.1
Rattus norvegicus (Norway rat)PdgfraNP_036934.1
Gallus gallus (chicken)PDGFRANP_990080.1
Danio rerio (zebrafish)pdgfraNP_571534.1
Caenorhabditis elegansC24G6.2NP_504459.1
Caenorhabditis eleganskin-9NP_001257058.1
Caenorhabditis elegansF09A5.2NP_510182.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100124862NP_001096290.1
GO:0001701in utero embryonic developmentIEA
GO:0001775cell activationTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007204positive regulation of cytosolic calcium ion concentrationIMP
GO:0008210estrogen metabolic processIEA
GO:0008284positive regulation of cell proliferationIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010544negative regulation of platelet activationIDA
GO:0010863positive regulation of phospholipase C activityIMP
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0016032viral processIEA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030198extracellular matrix organizationIEA
GO:0030324lung developmentIEA
GO:0030325adrenal gland developmentIEA
GO:0030335positive regulation of cell migrationIDA
GO:0030335positive regulation of cell migrationIMP
GO:0030539male genitalia developmentIEA
GO:0033327Leydig cell differentiationIEA
GO:0035790platelet-derived growth factor receptor-alpha signaling pathwayIMP
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042060wound healingISS
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityIMP
GO:0045087innate immune responseTAS
GO:0045740positive regulation of DNA replicationIDA
GO:0046777protein autophosphorylationIDA
GO:0048008platelet-derived growth factor receptor signaling pathwayIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingIMP
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048146positive regulation of fibroblast proliferationIDA
GO:0048557embryonic digestive tract morphogenesisISS
GO:0048701embryonic cranial skeleton morphogenesisISS
GO:0048704embryonic skeletal system morphogenesisISS
GO:0050920regulation of chemotaxisIMP
GO:0055003cardiac myofibril assemblyISS
GO:0060021palate developmentIEA
GO:0060325face morphogenesisIEA
GO:0060326cell chemotaxisIMP
GO:0061298retina vasculature development in camera-type eyeISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMP
GO:0070527platelet aggregationIMP
GO:0071230cellular response to amino acid stimulusIEA
GO:0072277metanephric glomerular capillary formationISS
GO:2000249regulation of actin cytoskeleton reorganizationTAS
GO:2000739regulation of mesenchymal stem cell differentiationIMP
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0009897external side of plasma membraneIEA
GO:0031226intrinsic component of plasma membraneIDA
GO:0004714transmembrane receptor protein tyrosine kinase activityIDA
GO:0005018platelet-derived growth factor alpha-receptor activityIDA
GO:0005018platelet-derived growth factor alpha-receptor activityIMP
GO:0005021vascular endothelial growth factor-activated receptor activityIDA
GO:0005161platelet-derived growth factor receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0038085vascular endothelial growth factor bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0048407platelet-derived growth factor bindingIDA
GO:0048407platelet-derived growth factor bindingIPI
GeneCards PDGFRA
UniProt P16234
Vega OTTHUMG00000128699
MIM 173490
Ensembl ENSG00000134853
HGNC 8803
HPRD 01429

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PDGFRA gene?

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. The PDGFRA protein is found in the cell membrane of certain cell types where a specific protein, called platelet-derived growth factor, attaches (binds) to it. This binding turns on (activates) the PDGFRA protein, which then activates other proteins inside the cell by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions (a process called phosphorylation). This process leads to the activation of a series of proteins in multiple signaling pathways.

The signaling pathways stimulated by the PDGFRA protein control many important cellular processes such as cell growth and division (proliferation) and cell survival. PDGFRA protein signaling is important for the development of many types of cells throughout the body.


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