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PDGFRA platelet-derived growth factor receptor, alpha polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_006206 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA. ORF Sequence $1144.50
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Gene Symbol PDGFRA
Entrez Gene ID 5156
Full Name platelet-derived growth factor receptor, alpha polypeptide
Synonyms CD140A, MGC74795, PDGFR2, RHEPDGFRA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12

Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].
Disorder

MIM: 173490

Gastrointestinal stromal tumor, somatic, 606764 (3);

mRNA Protein Product Sequence Price Select
NM_006206, 172072625 NP_006197, 5453870 platelet-derived growth factor receptor alpha precursor Full Length $2958.30
ORF Sequence $1144.50
KEGG
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
hsa05218Melanoma
hsa04151PI3K-Akt signaling pathway
hsa04020Calcium signaling pathway
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05214Glioma
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa05215Prostate cancer
Pathway Interaction Database
atf2_pathwayATF-2 transcription factor network
pdgfrapathwayPDGFR-alpha signaling pathway
WikiPathways
WP322Osteoblast Signaling
WP2261Signaling Pathways in Glioblastoma
WP2377Integrated Pancreatic Cancer Pathway
WP1539Angiogenesis
WP2256Integrated Pancreatic Cancer Pathway
WP51Regulation of Actin Cytoskeleton
WP306Focal Adhesion
Reactome
REACT_147814DAP12 signaling
REACT_9417Signaling by EGFR
REACT_6802Innate Immune System
REACT_75829PIP3 activates AKT signaling
REACT_115871Signaling by EGFR in Cancer
REACT_11061Signalling by NGF
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_17025Downstream signal transduction
REACT_115596Signaling by ERBB4
REACT_6900Immune System
REACT_115755Signaling by ERBB2
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_147694DAP12 interactions
REACT_120736Signaling by FGFR in disease
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_115961PI3K events in ERBB4 signaling
REACT_12464PI3K/AKT activation
REACT_21272Downstream signaling of activated FGFR
REACT_111102Signal Transduction
REACT_116008PI3K events in ERBB2 signaling
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_12578GAB1 signalosome
REACT_9470Signaling by FGFR
REACT_116125Disease
REACT_12056NGF signalling via TRKA from the plasma membrane
Homo sapiens (human)PDGFRANP_006197.1
Macaca mulatta (Rhesus monkey)PDGFRAXP_002808459.1
Canis lupus familiaris (dog)PDGFRAXP_532374.2
Bos taurus (cattle)PDGFRANP_001179274.1
Mus musculus (house mouse)PdgfraNP_001076785.1
Rattus norvegicus (Norway rat)PdgfraNP_036934.1
Gallus gallus (chicken)PDGFRANP_990080.1
Danio rerio (zebrafish)pdgfraNP_571534.1
GeneCards PDGFRA
PDB 1GQ5
UniProt P16234
MIM 173490
Ensembl ENSG00000134853
HGNC 8803
HPRD 01429

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
platelet-derived growth factor receptor alpha
Names
platelet-derived growth factor receptor alpha
PDGF-R-alpha
CD140a antigen
PDGFRA/BCR fusion
CD140 antigen-like family member A
platelet-derived growth factor receptor 2
alpha-type platelet-derived growth factor receptor
rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
NP_006197.1

Interactant

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