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PDGFRB platelet-derived growth factor receptor, beta polypeptide [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25829 NM_002609 Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mRNA. pcDNA3.1+-DYK In-stock 16 $1149.00
OHu39876 XM_005268464 PREDICTED: Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu25829C NM_002609 Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mRNA. Customized vector In-stock 16 $1149.00
OHu39876C XM_005268464 PREDICTED: Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol PDGFRB
Entrez Gene ID 5159
Full Name platelet-derived growth factor receptor, beta polypeptide
Synonyms CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
General protein information
Preferred Names
platelet-derived growth factor receptor beta
Names
platelet-derived growth factor receptor beta
PDGFR-beta
PDGF-R-beta
CD140 antigen-like family member B
platelet-derived growth factor receptor 1
beta-type platelet-derived growth factor receptor
NP_002600.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33.1

Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 173410

Myeloproliferative disorder with eosinophilia, 131440 (3);

mRNA Protein Product Sequence Price Select
NM_002609, 68216043 NP_002600, 4505683 platelet-derived growth factor receptor beta precursor ORF Sequence $999.00
XM_005268464, 578810889 XP_005268521, 530380588 platelet-derived growth factor receptor beta isoform X1 ORF Sequence $1500.00
KEGG
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05215Prostate cancer
hsa05214Glioma
hsa05200Pathways in cancer
hsa04540Gap junction
hsa05166HTLV-I infection
hsa04151PI3K-Akt signaling pathway
hsa05206MicroRNAs in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP51Regulation of Actin Cytoskeleton
WP322Osteoblast Signaling
WP2261Signaling Pathways in Glioblastoma
Pathway Interaction Database
s1p_s1p1_pathwayS1P1 pathway
ptp1bpathwaySignaling events mediated by PTP1B
nectin_pathwayNectin adhesion pathway
s1p_s1p3_pathwayS1P3 pathway
pdgfrbpathwayPDGFR-beta signaling pathway
tcptp_pathwaySignaling events mediated by TCPTP
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)PDGFRBNP_002600.1
Pan troglodytes (chimpanzee)PDGFRBXP_518034.3
Macaca mulatta (Rhesus monkey)PDGFRBXP_001107595.1
Canis lupus familiaris (dog)PDGFRBNP_001003382.1
Bos taurus (cattle)PDGFRBNP_001069364.2
Mus musculus (house mouse)PdgfrbNP_001139740.1
Rattus norvegicus (Norway rat)PdgfrbNP_113713.1
Gallus gallus (chicken)PDGFRBXP_001233830.1
Danio rerio (zebrafish)pdgfrbNP_001177862.1
Xenopus (Silurana) tropicalis (western clawed frog)pdgfrbXP_002940133.2
Process
IDNameEvidence
GO:0001701in utero embryonic developmentIEA
GO:0001894tissue homeostasisIEA
GO:0006024glycosaminoglycan biosynthetic processIEA
GO:0007165signal transductionIDA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0008284positive regulation of cell proliferationIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009636response to toxic substanceIEA
GO:0010863positive regulation of phospholipase C activityIDA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingISS
GO:0014911positive regulation of smooth muscle cell migrationIMP
GO:0014911positive regulation of smooth muscle cell migrationISS
GO:0016477cell migrationIMP
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0030325adrenal gland developmentIEA
GO:0030335positive regulation of cell migrationIDA
GO:0032355response to estradiolIEA
GO:0032516positive regulation of phosphoprotein phosphatase activityIDA
GO:0032526response to retinoic acidIEA
GO:0032956regulation of actin cytoskeleton organizationISS
GO:0032967positive regulation of collagen biosynthetic processIEA
GO:0034405response to fluid shear stressIEA
GO:0035441cell migration involved in vasculogenesisISS
GO:0035789metanephric mesenchymal cell migrationIEA
GO:0035791platelet-derived growth factor receptor-beta signaling pathwayIMP
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayISS
GO:0035909aorta morphogenesisISS
GO:0036120cellular response to platelet-derived growth factor stimulusTAS
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042060wound healingIEA
GO:0042542response to hydrogen peroxideIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043406positive regulation of MAP kinase activityISS
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityIDA
GO:0045087innate immune responseTAS
GO:0045840positive regulation of mitosisISS
GO:0046488phosphatidylinositol metabolic processIMP
GO:0046777protein autophosphorylationIDA
GO:0048008platelet-derived growth factor receptor signaling pathwayIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingIMP
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048661positive regulation of smooth muscle cell proliferationIMP
GO:0048661positive regulation of smooth muscle cell proliferationISS
GO:0048705skeletal system morphogenesisIEA
GO:0048745smooth muscle tissue developmentIEA
GO:0048839inner ear developmentIEA
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050921positive regulation of chemotaxisISS
GO:0055003cardiac myofibril assemblyISS
GO:0055093response to hyperoxiaIEA
GO:0060326cell chemotaxisIDA
GO:0060981cell migration involved in coronary angiogenesisISS
GO:0061298retina vasculature development in camera-type eyeISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMP
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0071670smooth muscle cell chemotaxisISS
GO:0072075metanephric mesenchyme developmentIEA
GO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros developmentISS
GO:0072277metanephric glomerular capillary formationISS
GO:0072278metanephric comma-shaped body morphogenesisIEA
GO:0072284metanephric S-shaped body morphogenesisIEA
GO:0090280positive regulation of calcium ion importISS
GO:2000379positive regulation of reactive oxygen species metabolic processISS
GO:2000573positive regulation of DNA biosynthetic processISS
Component
IDNameEvidence
GO:0005634nucleusISS
GO:0005737cytoplasmISS
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0016324apical plasma membraneISS
GO:0031226intrinsic component of plasma membraneIDA
GO:0043202lysosomal lumenIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityIDA
GO:0004992platelet activating factor receptor activityTAS
GO:0005017platelet-derived growth factor-activated receptor activityTAS
GO:0005019platelet-derived growth factor beta-receptor activityIDA
GO:0005019platelet-derived growth factor beta-receptor activityIMP
GO:0005102receptor bindingIPI
GO:0005161platelet-derived growth factor receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019901protein kinase bindingIPI
GO:0038085vascular endothelial growth factor bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingIEA
GO:0048407platelet-derived growth factor bindingIDA
GO:0048407platelet-derived growth factor bindingIPI
GeneCards PDGFRB
PDB 2L6W, 1H9O, 1LWP, 2PLD, 1GQ5, 2PLE, 1SHA, 3MJG
UniProt Q59F04, P09619
Vega OTTHUMG00000130053
MIM 173410
Ensembl ENSG00000113721
HGNC 8804
HPRD 01423

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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