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PDGFRB platelet-derived growth factor receptor, beta polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002609 Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16
XM_005268464 PREDICTED: Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol PDGFRB
Entrez Gene ID 5159
Full Name platelet-derived growth factor receptor, beta polypeptide
Synonyms CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
General protein information
Preferred Names
platelet-derived growth factor receptor beta
Names
platelet-derived growth factor receptor beta
PDGFR-beta
PDGF-R-beta
CD140 antigen-like family member B
platelet-derived growth factor receptor 1
beta-type platelet-derived growth factor receptor
NP_002600.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33.1

Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 173410

Myeloproliferative disorder with eosinophilia, 131440 (3);

mRNA Protein Product Sequence Price Select
NM_002609, 68216043 NP_002600, 4505683 platelet-derived growth factor receptor beta precursor ORF Sequence $999.00
XM_005268464, 578810889 XP_005268521, 530380588 platelet-derived growth factor receptor beta isoform X1 ORF Sequence $1500.00
KEGG
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05215Prostate cancer
hsa05214Glioma
hsa05200Pathways in cancer
hsa04540Gap junction
hsa05166HTLV-I infection
hsa04151PI3K-Akt signaling pathway
hsa05206MicroRNAs in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP51Regulation of Actin Cytoskeleton
WP322Osteoblast Signaling
WP2261Signaling Pathways in Glioblastoma
Pathway Interaction Database
s1p_s1p1_pathwayS1P1 pathway
ptp1bpathwaySignaling events mediated by PTP1B
nectin_pathwayNectin adhesion pathway
s1p_s1p3_pathwayS1P3 pathway
pdgfrbpathwayPDGFR-beta signaling pathway
tcptp_pathwaySignaling events mediated by TCPTP
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)PDGFRBNP_002600.1
Pan troglodytes (chimpanzee)PDGFRBXP_518034.3
Macaca mulatta (Rhesus monkey)PDGFRBXP_001107595.1
Canis lupus familiaris (dog)PDGFRBNP_001003382.1
Bos taurus (cattle)PDGFRBNP_001069364.2
Mus musculus (house mouse)PdgfrbNP_001139740.1
Rattus norvegicus (Norway rat)PdgfrbNP_113713.1
Gallus gallus (chicken)PDGFRBXP_001233830.1
Danio rerio (zebrafish)pdgfrbNP_001177862.1
Xenopus (Silurana) tropicalis (western clawed frog)pdgfrbXP_002940133.2
Process
IDNameEvidence
GO:0001701in utero embryonic developmentIEA
GO:0001894tissue homeostasisIEA
GO:0006024glycosaminoglycan biosynthetic processIEA
GO:0007165signal transductionIDA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0008284positive regulation of cell proliferationIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009636response to toxic substanceIEA
GO:0010863positive regulation of phospholipase C activityIDA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingISS
GO:0014911positive regulation of smooth muscle cell migrationIMP
GO:0014911positive regulation of smooth muscle cell migrationISS
GO:0016477cell migrationIMP
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0030325adrenal gland developmentIEA
GO:0030335positive regulation of cell migrationIDA
GO:0032355response to estradiolIEA
GO:0032516positive regulation of phosphoprotein phosphatase activityIDA
GO:0032526response to retinoic acidIEA
GO:0032956regulation of actin cytoskeleton organizationISS
GO:0032967positive regulation of collagen biosynthetic processIEA
GO:0034405response to fluid shear stressIEA
GO:0035441cell migration involved in vasculogenesisISS
GO:0035789metanephric mesenchymal cell migrationIEA
GO:0035791platelet-derived growth factor receptor-beta signaling pathwayIMP
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayISS
GO:0035909aorta morphogenesisISS
GO:0036120cellular response to platelet-derived growth factor stimulusTAS
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042060wound healingIEA
GO:0042542response to hydrogen peroxideIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043406positive regulation of MAP kinase activityISS
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityIDA
GO:0045087innate immune responseTAS
GO:0045840positive regulation of mitosisISS
GO:0046488phosphatidylinositol metabolic processIMP
GO:0046777protein autophosphorylationIDA
GO:0048008platelet-derived growth factor receptor signaling pathwayIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingIMP
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048661positive regulation of smooth muscle cell proliferationIMP
GO:0048661positive regulation of smooth muscle cell proliferationISS
GO:0048705skeletal system morphogenesisIEA
GO:0048745smooth muscle tissue developmentIEA
GO:0048839inner ear developmentIEA
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050921positive regulation of chemotaxisISS
GO:0055003cardiac myofibril assemblyISS
GO:0055093response to hyperoxiaIEA
GO:0060326cell chemotaxisIDA
GO:0060981cell migration involved in coronary angiogenesisISS
GO:0061298retina vasculature development in camera-type eyeISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMP
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0071670smooth muscle cell chemotaxisISS
GO:0072075metanephric mesenchyme developmentIEA
GO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros developmentISS
GO:0072277metanephric glomerular capillary formationISS
GO:0072278metanephric comma-shaped body morphogenesisIEA
GO:0072284metanephric S-shaped body morphogenesisIEA
GO:0090280positive regulation of calcium ion importISS
GO:2000379positive regulation of reactive oxygen species metabolic processISS
GO:2000573positive regulation of DNA biosynthetic processISS
Component
IDNameEvidence
GO:0005634nucleusISS
GO:0005737cytoplasmISS
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0016324apical plasma membraneISS
GO:0031226intrinsic component of plasma membraneIDA
GO:0043202lysosomal lumenIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityIDA
GO:0004992platelet activating factor receptor activityTAS
GO:0005017platelet-derived growth factor-activated receptor activityTAS
GO:0005019platelet-derived growth factor beta-receptor activityIDA
GO:0005019platelet-derived growth factor beta-receptor activityIMP
GO:0005102receptor bindingIPI
GO:0005161platelet-derived growth factor receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019901protein kinase bindingIPI
GO:0038085vascular endothelial growth factor bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingIEA
GO:0048407platelet-derived growth factor bindingIDA
GO:0048407platelet-derived growth factor bindingIPI
GeneCards PDGFRB
PDB 2L6W, 1H9O, 1LWP, 2PLD, 1GQ5, 2PLE, 1SHA, 3MJG
UniProt Q59F04, P09619
Vega OTTHUMG00000130053
MIM 173410
Ensembl ENSG00000113721
HGNC 8804
HPRD 01423

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PDGFRB gene?

The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which is part of a family of proteins called receptor tyrosine kinases. Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. The PDGFRβ protein is found in the cell membrane of certain cell types, where a protein called platelet-derived growth factor attaches (binds) to it. This binding turns on (activates) the PDGFRβ protein, which then activates other proteins inside the cell by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process, called phosphorylation, leads to the activation of a series of proteins in multiple signaling pathways.

The signaling pathways stimulated by the PDGFRβ protein control many important processes in the cell such as growth and division (proliferation), movement, and survival. PDGFRβ protein signaling is important for the development of many types of cells throughout the body.

Interactant

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