PDGFRB platelet-derived growth factor receptor, beta polypeptide [Homo sapiens (human)]
| Gene Symbol | PDGFRB |
| Entrez Gene ID | 5159 |
| Full Name | platelet-derived growth factor receptor, beta polypeptide |
| Synonyms | CD140B, JTK12, PDGFR, PDGFR1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
5 5q33.1 |
| Summary | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq]. |
| Disorder | MIM: 173410 Myeloproliferative disorder with eosinophilia, 131440 (3); |
| mRNA | NM_002609, 68216043 |
| Protein | NP_002600, 4505683 |
| Product | beta-type platelet-derived growth factor receptor precursor |
| RefSeq Status | REVIEWED |
| hsa05218 | Melanoma |
| hsa04020 | Calcium signaling pathway |
| hsa05214 | Glioma |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04540 | Gap junction |
| hsa05215 | Prostate cancer |
| hsa05200 | Pathways in cancer |
| hsa04510 | Focal adhesion |
| hsa04010 | MAPK signaling pathway |
WikiPathways
| WP51 | Regulation of Actin Cytoskeleton |
| WP306 | Focal Adhesion |
| WP382 | MAPK signaling pathway |
| WP322 | Osteoblast Signaling |
Pathway Interaction Database
| myc_represspathway | Validated targets of C-MYC transcriptional repression |
| ptp1bpathway | Signaling events mediated by PTP1B |
| pdgfrbpathway | PDGFR-beta signaling pathway |
| tcptp_pathway | Signaling events mediated by TCPTP |
| s1p_s1p3_pathway | S1P3 pathway |
| nectin_pathway | Nectin adhesion pathway |
| s1p_s1p1_pathway | S1P1 pathway |
Reactome
| REACT_16888 | Signaling by PDGF |
| REACT_17025 | Down-stream signal transduction |
| Homo sapiens (human) | PDGFRB | NP_002600.1 |
| Pan troglodytes (chimpanzee) | PDGFRB | XP_518034.2 |
| Canis lupus familiaris (dog) | PDGFRB | NP_001003382.1 |
| Bos taurus (cattle) | PDGFRB | XP_001790034.1 |
| Mus musculus (house mouse) | Pdgfrb | NP_032835.1 |
| Rattus norvegicus (Norway rat) | Pdgfrb | NP_113713.1 |
| Gallus gallus (chicken) | PDGFRB | XP_001233830.1 |
| Danio rerio (zebrafish) | pdgfrb | XP_687967.4 |
| ID | Name | Evidence |
| GO:0007165 | signal transduction | IDA |
| GO:0008284 | positive regulation of cell proliferation | IDA |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase cascade | ISS |
| GO:0014911 | positive regulation of smooth muscle cell migration | ISS |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0030097 | hemopoiesis | ISS |
| GO:0030335 | positive regulation of cell migration | IDA |
| GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | IDA |
| GO:0035793 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway | ISS |
| GO:0043406 | positive regulation of MAP kinase activity | ISS |
| GO:0045840 | positive regulation of mitosis | ISS |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IDA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | TAS |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | ISS |
| GO:0050921 | positive regulation of chemotaxis | ISS |
| GO:0055003 | cardiac myofibril assembly | ISS |
| GO:0060326 | cell chemotaxis | IDA |
| GO:0061298 | retina vasculature development in camera-type eye | ISS |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISS |
| GO:0072262 | metanephric glomerular mesangial cell proliferation involved in metanephros development | ISS |
| GO:0072277 | metanephric glomerular capillary formation | ISS |
| GO:0090280 | positive regulation of calcium ion import | ISS |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | ISS |
| GO:2000573 | positive regulation of DNA biosynthetic process | ISS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | ISS |
| GO:0005737 | cytoplasm | ISS |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | IEA |
| GO:0016020 | membrane | IDA |
| GO:0016324 | apical plasma membrane | ISS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004713 | protein tyrosine kinase activity | EXP |
| GO:0004872 | receptor activity | IEA |
| GO:0004992 | platelet activating factor receptor activity | TAS |
| GO:0005017 | platelet-derived growth factor receptor activity | TAS |
| GO:0005019 | platelet-derived growth factor beta-receptor activity | IDA |
| GO:0005021 | vascular endothelial growth factor receptor activity | IEA |
| GO:0005102 | receptor binding | IPI |
| GO:0005161 | platelet-derived growth factor receptor binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0019838 | growth factor binding | IPI |
| GO:0048407 | platelet-derived growth factor binding | IPI |
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