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Sequence in raw or FASTA format:

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PDGFRB platelet-derived growth factor receptor, beta polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002609 Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mRNA. ORF Sequence $1162.35
Peptide Services
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Gene Symbol PDGFRB
Entrez Gene ID 5159
Full Name platelet-derived growth factor receptor, beta polypeptide
Synonyms CD140B, JTK12, PDGFR, PDGFR1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33.1

Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 173410

Myeloproliferative disorder with eosinophilia, 131440 (3);

mRNA Protein Product Sequence Price Select
NM_002609, 68216043 NP_002600, 4505683 platelet-derived growth factor receptor beta precursor Full Length $2573.10
ORF Sequence $1162.35
KEGG
hsa04510Focal adhesion
hsa04010MAPK signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa05200Pathways in cancer
hsa04020Calcium signaling pathway
hsa05166HTLV-I infection
hsa05218Melanoma
hsa04060Cytokine-cytokine receptor interaction
hsa05214Glioma
hsa04810Regulation of actin cytoskeleton
hsa04540Gap junction
hsa05215Prostate cancer
Pathway Interaction Database
myc_represspathwayValidated targets of C-MYC transcriptional repression
ptp1bpathwaySignaling events mediated by PTP1B
s1p_s1p1_pathwayS1P1 pathway
pdgfrbpathwayPDGFR-beta signaling pathway
tcptp_pathwaySignaling events mediated by TCPTP
s1p_s1p3_pathwayS1P3 pathway
nectin_pathwayNectin adhesion pathway
WikiPathways
WP2261Signaling Pathways in Glioblastoma
WP322Osteoblast Signaling
WP51Regulation of Actin Cytoskeleton
WP306Focal Adhesion
WP382MAPK signaling pathway
Reactome
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_147814DAP12 signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_115755Signaling by ERBB2
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12464PI3K/AKT activation
REACT_115596Signaling by ERBB4
REACT_147694DAP12 interactions
REACT_111040Signaling by SCF-KIT
REACT_75774Adaptive Immune System
REACT_120736Signaling by FGFR in disease
REACT_21270PI-3K cascade
REACT_115961PI3K events in ERBB4 signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_75829PIP3 activates AKT signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_16888Signaling by PDGF
REACT_12578GAB1 signalosome
REACT_9470Signaling by FGFR
REACT_6900Immune System
Homo sapiens (human)PDGFRBNP_002600.1
Pan troglodytes (chimpanzee)PDGFRBXP_518034.3
Macaca mulatta (Rhesus monkey)PDGFRBXP_001107595.1
Canis lupus familiaris (dog)PDGFRBNP_001003382.1
Bos taurus (cattle)PDGFRBNP_001069364.2
Mus musculus (house mouse)PdgfrbNP_001139740.1
Rattus norvegicus (Norway rat)PdgfrbNP_113713.1
Gallus gallus (chicken)PDGFRBXP_001233830.1
Danio rerio (zebrafish)pdgfrbNP_001177862.1
GeneCards PDGFRB
PDB 2L6W, 1LWP, 1GQ5, 1H9O, 3MJG
UniProt Q59F04, P09619
MIM 173410
Ensembl ENSG00000113721
HGNC 8804
HPRD 01423

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
platelet-derived growth factor receptor beta
Names
platelet-derived growth factor receptor beta
PDGFR-beta
PDGF-R-beta
CD140 antigen-like family member B
platelet-derived growth factor receptor 1
beta-type platelet-derived growth factor receptor
NP_002600.1

Interactant

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