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PDHB pyruvate dehydrogenase (lipoamide) beta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu09402 NM_001173468 Homo sapiens pyruvate dehydrogenase (lipoamide) beta (PDHB), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18263 NM_000925 Homo sapiens pyruvate dehydrogenase (lipoamide) beta (PDHB), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu09402C NM_001173468 Homo sapiens pyruvate dehydrogenase (lipoamide) beta (PDHB), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu18263C NM_000925 Homo sapiens pyruvate dehydrogenase (lipoamide) beta (PDHB), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PDHB
Entrez Gene ID 5162
Full Name pyruvate dehydrogenase (lipoamide) beta
Synonyms PDHBD, PDHE1-B, PHE1B
General protein information
Preferred Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
pyruvate dehydrogenase, E1 beta polypeptide
NP_000916.2
NP_001166939.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.1-p14.2

Summary The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012].
Disorder

MIM: 179060

Pyruvate dehydrogenase E1-beta deficiency (3)

mRNA Protein Product Sequence Price Select
NM_000925, 291084856 NP_000916, 156564403 pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform 1 precursor ORF Sequence $269.00
NM_001173468, 291084857 NP_001166939, 291084858 pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform 2 precursor ORF Sequence $400.00
KEGG
hsa00020Citrate cycle (TCA cycle)
hsa00010Glycolysis / Gluconeogenesis
hsa00620Pyruvate metabolism
hsa_M00307Pyruvate oxidation, pyruvate => acetyl-CoA
hsa04066HIF-1 signaling pathway
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
BIOCYC
META_PYRUVDEHYD-PWYpyruvate decarboxylation to acetyl CoA
HUMAN_PYRUVDEHYD-PWYpyruvate decarboxylation to acetyl CoA
Reactome
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111217Metabolism
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)PDHBNP_000916.2
Pan troglodytes (chimpanzee)PDHBNP_001233347.1
Macaca mulatta (Rhesus monkey)PDHBXP_001096445.1
Canis lupus familiaris (dog)PDHBXP_533778.2
Bos taurus (cattle)PDHBNP_001030512.2
Mus musculus (house mouse)PdhbNP_077183.1
Rattus norvegicus (Norway rat)PdhbNP_001007621.1
Gallus gallus (chicken)PDHBNP_001185549.1
Danio rerio (zebrafish)pdhbNP_998319.1
Drosophila melanogaster (fruit fly)CG11876NP_651668.1
Caenorhabditis eleganspdhb-1NP_500340.1
Arabidopsis thaliana (thale cress)MAB1NP_199898.1
Xenopus (Silurana) tropicalis (western clawed frog)pdhbNP_001016212.1
Process
IDNameEvidence
GO:0006006glucose metabolic processIEA
GO:0006086acetyl-CoA biosynthetic process from pyruvateIDA
GO:0006090pyruvate metabolic processTAS
GO:0006099tricarboxylic acid cycleIDA
GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvateTAS
GO:0044237cellular metabolic processTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005759mitochondrial matrixTAS
GO:0045254pyruvate dehydrogenase complexIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004738pyruvate dehydrogenase activityIDA
GO:0004739pyruvate dehydrogenase (acetyl-transferring) activityIEA
GO:0005515protein bindingIPI
GeneCards PDHB
UniProt P11177
Vega OTTHUMG00000159157
MIM 179060
Ensembl ENSG00000168291
HGNC 8808
HPRD 01530

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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