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PDPK1 3-phosphoinositide dependent protein kinase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001261816 Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_002613 Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_031268 Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_005255356 PREDICTED: Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDPK1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol PDPK1
Entrez Gene ID 5170
Full Name 3-phosphoinositide dependent protein kinase 1
Synonyms PDK1, PDPK2, PRO0461
General protein information
Preferred Names
3-phosphoinositide-dependent protein kinase 1
Names
3-phosphoinositide-dependent protein kinase 1
PkB-like 1
PkB kinase like gene 1
NP_001248745.1
NP_002604.1
NP_112558.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p13.3

Summary
Disorder

MIM: 605213

mRNA Protein Product Sequence Price Select
NM_001261816, 387849238 NP_001248745, 387849239 3-phosphoinositide-dependent protein kinase 1 isoform 3 ORF Sequence $550.00
NM_002613, 387849236 NP_002604, 4505695 3-phosphoinositide-dependent protein kinase 1 isoform 1 ORF Sequence $360.00
NM_031268, 387849237 NP_112558, 47680169 3-phosphoinositide-dependent protein kinase 1 isoform 2 ORF Sequence $360.00
XM_005255356, 530408206 XP_005255413, 530408207 3-phosphoinositide-dependent protein kinase 1 isoform X1 ORF Sequence $550.00
KEGG
hsa03320PPAR signaling pathway
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04660T cell receptor signaling pathway
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05223Non-small cell lung cancer
hsa04722Neurotrophin signaling pathway
hsa05145Toxoplasmosis
hsa04960Aldosterone-regulated sodium reabsorption
hsa05160Hepatitis C
hsa04151PI3K-Akt signaling pathway
hsa05205Proteoglycans in cancer
hsa04919Thyroid hormone signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
WikiPathways
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP481Insulin Signaling
WP185Integrin-mediated cell adhesion
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP2332Interleukin-11 Signaling Pathway
WP2380BDNF signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP2032TSH signaling pathway
Pathway Interaction Database
cxcr4_pathwayCXCR4-mediated signaling events
vegfr1_pathwayVEGFR1 specific signals
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
tcr_pathwayTCR signaling in naive CD4+ T cells
fgf_pathwayFGF signaling pathway
igf1_pathwayIGF1 pathway
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pi3kcipathwayClass I PI3K signaling events
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
erbb1_downstream_pathwayErbB1 downstream signaling
tgfbrpathwayTGF-beta receptor signaling
faspathwayFAS (CD95) signaling pathway
cd8tcrpathwayTCR signaling in naive CD8+ T cells
cxcr3pathwayCXCR3-mediated signaling events
insulin_pathwayInsulin Pathway
bcr_5pathwayBCR signaling pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
mtor_4pathwaymTOR signaling pathway
Reactome
REACT_19184GPCR downstream signaling
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19388G-protein beta:gamma signalling
REACT_19183CD28 co-stimulation
REACT_19344Costimulation by the CD28 family
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19405CTLA4 inhibitory signaling
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1695GPVI-mediated activation cascade
REACT_278Platelet Aggregation (Plug Formation)
REACT_15523Integrin alphaIIb beta3 signaling
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_976PI3K Cascade
REACT_790Activation of PKB
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_12555Downstream TCR signaling
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_13477Transmission across Chemical Synapses
REACT_12526TCR signaling
REACT_13685Neuronal System
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_20568CREB phosphorylation through the activation of Ras
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20593Post NMDA receptor activation events
REACT_20510RSK activation
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)PDPK1NP_002604.1
Pan troglodytes (chimpanzee)PDPK1XP_003952817.1
Canis lupus familiaris (dog)PDPK1XP_005621736.1
Bos taurus (cattle)PDPK1XP_002697908.2
Mus musculus (house mouse)Pdpk1NP_035192.2
Rattus norvegicus (Norway rat)Pdpk1NP_112343.1
Gallus gallus (chicken)PDPK1NP_001012547.1
Danio rerio (zebrafish)pdpk1bNP_991262.1
Drosophila melanogaster (fruit fly)Pdk1NP_728473.1
Caenorhabditis eleganspdk-1NP_001024742.1
Arabidopsis thaliana (thale cress)PDK1NP_568138.1
Arabidopsis thaliana (thale cress)AT3G10540NP_187665.2
Xenopus (Silurana) tropicalis (western clawed frog)pdpk1XP_002938460.2
Process
IDNameEvidence
GO:0003323type B pancreatic cell developmentIEA
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006468protein phosphorylationIDA
GO:0006468protein phosphorylationIEA
GO:0006469negative regulation of protein kinase activityIDA
GO:0006972hyperosmotic responseIEA
GO:0007173epidermal growth factor receptor signaling pathwayIMP
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007268synaptic transmissionTAS
GO:0007596blood coagulationTAS
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010518positive regulation of phospholipase activityIMP
GO:0010594regulation of endothelial cell migrationIEA
GO:0010667negative regulation of cardiac muscle cell apoptotic processIEA
GO:0016477cell migrationIMP
GO:0018107peptidyl-threonine phosphorylationIDA
GO:0019722calcium-mediated signalingIMP
GO:0030036actin cytoskeleton organizationTAS
GO:0030168platelet activationTAS
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0031295T cell costimulationTAS
GO:0032148activation of protein kinase B activityIDA
GO:0032869cellular response to insulin stimulusIMP
GO:0034122negative regulation of toll-like receptor signaling pathwayIEA
GO:0035556intracellular signal transductionIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0043122regulation of I-kappaB kinase/NF-kappaB signalingIMP
GO:0043304regulation of mast cell degranulationIEA
GO:0045087innate immune responseTAS
GO:0046777protein autophosphorylationTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048041focal adhesion assemblyIEA
GO:0050852T cell receptor signaling pathwayTAS
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA
GO:0071364cellular response to epidermal growth factor stimulusIMP
GO:0090004positive regulation of establishment of protein localization to plasma membraneIMP
GO:0097191extrinsic apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0005737cytoplasmIEA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005925focal adhesionIEA
GO:0016020membraneIEA
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0042995cell projectionIDA
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityIDA
GO:0004674protein serine/threonine kinase activityIEA
GO:0004674protein serine/threonine kinase activityTAS
GO:00046763-phosphoinositide-dependent protein kinase activityIDA
GO:0005158insulin receptor bindingIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0016004phospholipase activator activityIMP
GO:0016301kinase activityEXP
GO:0019901protein kinase bindingIEA
GO:0043274phospholipase bindingIPI
GeneCards PDPK1
UniProt E9PER6, O15530
Vega OTTHUMG00000128874
MIM 605213
Ensembl ENSG00000140992
HGNC 8816
HPRD 05556

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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