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RAB23 RAB23, member RAS oncogene family [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001278666 Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001278667 Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001278668 Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_016277 Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_183227 Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
XM_005249179 PREDICTED: Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $299.00 14

*Business Day

Related Services

Gene Symbol RAB23
Entrez Gene ID 51715
Full Name RAB23, member RAS oncogene family
Synonyms HSPC137
General protein information
Preferred Names
ras-related protein Rab-23
Names
ras-related protein Rab-23
RAB family small GTP binding protein RAB 23
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p11

Summary This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder

MIM: 606144

Carpenter syndrome, 201000 (3)

mRNA Protein Product Sequence Price Select
NM_001278666, 523425713 NP_001265595, 523425714 ras-related protein Rab-23 ORF Sequence $250.00
NM_001278667, 523425715 NP_001265596, 523425716 ras-related protein Rab-23 ORF Sequence $250.00
NM_001278668, 523425717 NP_001265597, 523425718 ras-related protein Rab-23 ORF Sequence $250.00
NM_016277, 523425711 NP_057361, 34485714 ras-related protein Rab-23 ORF Sequence $159.00
NM_183227, 523425712 NP_899050, 34485716 ras-related protein Rab-23 ORF Sequence $159.00
XM_005249179, 530382145 XP_005249236, 530382146 ras-related protein Rab-23 isoform X1 ORF Sequence $150.00
KEGG
hsa04340Hedgehog signaling pathway
WikiPathways
WP47Hedgehog Signaling Pathway
Pathway Interaction Database
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
Homo sapiens (human)RAB23NP_001265595.1
Pan troglodytes (chimpanzee)RAB23XP_527422.2
Macaca mulatta (Rhesus monkey)RAB23XP_001110815.1
Canis lupus familiaris (dog)LOC481854XP_005627565.1
Bos taurus (cattle)RAB23NP_001193835.1
Mus musculus (house mouse)Rab23NP_033025.2
Rattus norvegicus (Norway rat)Rab23NP_001102475.1
Gallus gallus (chicken)RAB23NP_001103530.1
Danio rerio (zebrafish)rab23NP_001018579.1
Drosophila melanogaster (fruit fly)Rab23NP_649574.1
Xenopus (Silurana) tropicalis (western clawed frog)rab23NP_001016964.1
Process
IDNameEvidence
GO:0000045autophagic vacuole assemblyIMP
GO:0006184GTP catabolic processIDA
GO:0006968cellular defense responseIMP
GO:0007264small GTPase mediated signal transductionIEA
GO:0008589regulation of smoothened signaling pathwayIEA
GO:0015031protein transportIEA
GO:0021513spinal cord dorsal/ventral patterningIEA
GO:0042733embryonic digit morphogenesisIEA
GO:0042992negative regulation of transcription factor import into nucleusIMP
GO:0045861negative regulation of proteolysisIEA
GO:0097094craniofacial suture morphogenesisIMP
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005776autophagic vacuoleIDA
GO:0005886plasma membraneIEA
GO:0010008endosome membraneIEA
GO:0030670phagocytic vesicle membraneIEA
GO:0045335phagocytic vesicleIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003924GTPase activityIDA
GO:0005525GTP bindingIEA
GeneCards RAB23
UniProt Q9ULC3
MIM 606144
HGNC 14263
HPRD 05850

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RAB23 gene?

The RAB23 gene provides instructions for making a protein that is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. A vesicle forms when the cell membrane folds around a substance outside the cell (such as a protein). The vesicle is drawn into the cell, pinched off from the cell membrane (a process called endocytosis), and attached to the Rab23 protein. Once inside the cell, the vesicle is guided by the Rab23 protein to its proper destination. Vesicle trafficking is important for the transport of materials that are needed to trigger signaling during development.

Through the transport of certain proteins, the Rab23 protein regulates a specific developmental pathway called the hedgehog signaling pathway that is critical in cell growth (proliferation), cell specialization, and the normal shaping (patterning) of many parts of the body during embryonic development.

Interactant

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