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ERAP1 endoplasmic reticulum aminopeptidase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001040458 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001198541 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_016442 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol ERAP1
Entrez Gene ID 51752
Full Name endoplasmic reticulum aminopeptidase 1
Synonyms A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, KIAA0525, PILS-AP, PILSAP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q15

Summary The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
Disorder

MIM: 606832

mRNA Protein Product Sequence Price Select
NM_001040458, 94818890 NP_001035548, 94818891 endoplasmic reticulum aminopeptidase 1 isoform b ORF Sequence $660.00
NM_001198541, 309747090 NP_001185470, 309747091 endoplasmic reticulum aminopeptidase 1 isoform b ORF Sequence $660.00
NM_016442, 94818900 NP_057526, 94818901 endoplasmic reticulum aminopeptidase 1 isoform a ORF Sequence $750.00
Reactome
REACT_6900Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_75774Adaptive Immune System
Homo sapiens (human)ERAP1NP_057526.3
Pan troglodytes (chimpanzee)ERAP1XP_003310814.1
Macaca mulatta (Rhesus monkey)ERAP1XP_001094790.1
Canis lupus familiaris (dog)ERAP1XP_546015.3
Bos taurus (cattle)ERAP1NP_001095473.1
Mus musculus (house mouse)Erap1NP_109636.1
Rattus norvegicus (Norway rat)Erap1NP_110463.1
Gallus gallus (chicken)ERAP1XP_001232418.2
Danio rerio (zebrafish)zgc:56194NP_956500.2
Danio rerio (zebrafish)erap1XP_692516.3
GeneCards ERAP1
PDB 3QNF, 2YD0, 3MDJ, 3RJO
UniProt Q9NZ08
MIM 606832
Ensembl ENSG00000164307
HGNC 18173
HPRD 06015

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
endoplasmic reticulum aminopeptidase 1
Names
endoplasmic reticulum aminopeptidase 1
aminopeptidase PILS
adipocyte-derived leucine aminopeptidase
aminopeptidase regulator of TNFR1 shedding
puromycin-insensitive leucyl-specific aminopeptidase
endoplasmic reticulum aminopeptidase associated with antigen processing
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Interactant



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