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ERAP1 endoplasmic reticulum aminopeptidase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001040458 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001198541 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_016442 Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005272015 PREDICTED: Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005272016 PREDICTED: Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

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Gene Symbol ERAP1
Entrez Gene ID 51752
Full Name endoplasmic reticulum aminopeptidase 1
Synonyms A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
General protein information
Preferred Names
endoplasmic reticulum aminopeptidase 1
Names
endoplasmic reticulum aminopeptidase 1
aminopeptidase PILS
adipocyte-derived leucine aminopeptidase
aminopeptidase regulator of TNFR1 shedding
puromycin-insensitive leucyl-specific aminopeptidase
endoplasmic reticulum aminopeptidase associated with antigen processing
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q15

Summary The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
Disorder

MIM: 606832

mRNA Protein Product Sequence Price Select
NM_001040458, 94818890 NP_001035548, 94818891 endoplasmic reticulum aminopeptidase 1 isoform b precursor ORF Sequence $660.00
NM_001198541, 309747090 NP_001185470, 309747091 endoplasmic reticulum aminopeptidase 1 isoform b precursor ORF Sequence $660.00
NM_016442, 94818900 NP_057526, 94818901 endoplasmic reticulum aminopeptidase 1 isoform a precursor ORF Sequence $750.00
XM_005272015, 578810441 XP_005272072, 530380009 endoplasmic reticulum aminopeptidase 1 isoform X1 ORF Sequence $750.00
XM_005272016, 578810442 XP_005272073, 530380011 endoplasmic reticulum aminopeptidase 1 isoform X2 ORF Sequence $750.00
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_75820Class I MHC mediated antigen processing & presentation
Homo sapiens (human)ERAP1NP_057526.3
Pan troglodytes (chimpanzee)ERAP1XP_003310814.1
Macaca mulatta (Rhesus monkey)ERAP1XP_001094790.1
Canis lupus familiaris (dog)ERAP1XP_005618143.1
Bos taurus (cattle)ERAP1NP_001095473.1
Mus musculus (house mouse)Erap1NP_109636.1
Rattus norvegicus (Norway rat)Erap1NP_110463.1
Gallus gallus (chicken)ERAP1XP_001232418.2
Danio rerio (zebrafish)zgc:56194NP_956500.2
Danio rerio (zebrafish)si:dkey-24n17.6XP_005155589.1
Xenopus (Silurana) tropicalis (western clawed frog)erap1XP_002933475.2
Process
IDNameEvidence
GO:0001525angiogenesisTAS
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0006509membrane protein ectodomain proteolysisIDA
GO:0008217regulation of blood pressureNAS
GO:0008217regulation of blood pressureTAS
GO:0009617response to bacteriumIEP
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class INAS
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class ITAS
GO:0045088regulation of innate immune responseNAS
GO:0045444fat cell differentiationNAS
GO:0045766positive regulation of angiogenesisIEA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005615extracellular spaceIDA
GO:0005783endoplasmic reticulumNAS
GO:0005788endoplasmic reticulum lumenTAS
GO:0005789endoplasmic reticulum membraneIEA
GO:0005829cytosolNAS
GO:0016020membraneIDA
GO:0016021integral component of membraneNAS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004177aminopeptidase activityIDA
GO:0005138interleukin-6 receptor bindingIPI
GO:0005151interleukin-1, Type II receptor bindingTAS
GO:0005515protein bindingIPI
GO:0008235metalloexopeptidase activityIDA
GO:0008270zinc ion bindingNAS
GeneCards ERAP1
UniProt Q9NZ08
Vega OTTHUMG00000128721
MIM 606832
Ensembl ENSG00000164307
HGNC 18173
HPRD 06015

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ERAP1 gene?

The ERAP1 gene (also known as ERAAP and ARTS1) provides instructions for making a protein called endoplasmic reticulum aminopeptidase 1. As its name suggests, this protein is active in a cellular structure called the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cuts (cleaves) other proteins into smaller fragments called peptides.

Endoplasmic reticulum aminopeptidase 1 has two major functions, both of which are important for normal immune system function. First, endoplasmic reticulum aminopeptidase 1 cleaves several proteins called cytokine receptors on the surface of cells. Cleaving these receptors reduces their ability to transmit chemical signals into the cell, which affects the process of inflammation.

Second, endoplasmic reticulum aminopeptidase 1 cleaves many types of proteins into small peptides that can be recognized by the immune system. These peptides are exported to the cell surface, where they attach to major histocompatibility complex (MHC) class I proteins. MHC class I proteins display the peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by triggering the infected cell to self-destruct.

Interactant

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