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SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18617 NM_002615 Homo sapiens serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18617C NM_002615 Homo sapiens serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol SERPINF1
Entrez Gene ID 5176
Full Name serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Synonyms EPC-1, OI12, OI6, PEDF
General protein information
Preferred Names
pigment epithelium-derived factor
Names
pigment epithelium-derived factor
serpin F1
cell proliferation-inducing gene 35 protein
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.3

Summary The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011].
Disorder

MIM: 172860

mRNA Protein Product Sequence Price Select
NM_002615, 318037587 NP_002606, 39725934 pigment epithelium-derived factor precursor ORF Sequence $550.00
Homo sapiens (human)SERPINF1NP_002606.3
Pan troglodytes (chimpanzee)SERPINF1XP_001155004.1
Canis lupus familiaris (dog)SERPINF1NP_001071056.2
Bos taurus (cattle)SERPINF1NP_776565.1
Mus musculus (house mouse)Serpinf1NP_035470.3
Rattus norvegicus (Norway rat)Serpinf1NP_808788.1
Gallus gallus (chicken)SERPINF1NP_001244218.1
Danio rerio (zebrafish)serpinf1NP_001004539.1
Xenopus (Silurana) tropicalis (western clawed frog)serpinf1NP_989086.1
Process
IDNameEvidence
GO:0001822kidney developmentIEA
GO:0007275multicellular organismal developmentTAS
GO:0007568agingIEA
GO:0007614short-term memoryIEA
GO:0008283cell proliferationTAS
GO:0010951negative regulation of endopeptidase activityIBA
GO:0016525negative regulation of angiogenesisIDA
GO:0030162regulation of proteolysisIBA
GO:0032526response to retinoic acidIEA
GO:0050728negative regulation of inflammatory responseIEA
GO:0050769positive regulation of neurogenesisIDA
GO:0051384response to glucocorticoidIEA
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005615extracellular spaceIDA
GO:0031012extracellular matrixIDA
GO:0042470melanosomeIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004867serine-type endopeptidase inhibitor activityIBA
GeneCards SERPINF1
PDB 1IMV
UniProt P36955
Vega OTTHUMG00000090571
MIM 172860
Ensembl ENSG00000132386
HGNC 8824
HPRD 01408

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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