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PEPD peptidase D [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000285 Homo sapiens peptidase D (PEPD), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001166056 Homo sapiens peptidase D (PEPD), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001166057 Homo sapiens peptidase D (PEPD), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol PEPD
Entrez Gene ID 5184
Full Name peptidase D
General protein information
Preferred Names
xaa-Pro dipeptidase
xaa-Pro dipeptidase
X-Pro dipeptidase
proline dipeptidase
aminoacyl-L-proline hydrolase
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

MIM: 613230

Prolidase deficiency, 170100 (3)

mRNA Protein Product Sequence Price Select
NM_000285, 260593661 NP_000276, 149589008 xaa-Pro dipeptidase isoform 1 ORF Sequence $360.00
NM_001166056, 260593662 NP_001159528, 260593663 xaa-Pro dipeptidase isoform 2 ORF Sequence $550.00
NM_001166057, 260593664 NP_001159529, 260593665 xaa-Pro dipeptidase isoform 3 ORF Sequence $550.00
Homo sapiens (human)PEPDNP_000276.2
Pan troglodytes (chimpanzee)PEPDXP_512574.3
Macaca mulatta (Rhesus monkey)PEPDXP_001108725.2
Canis lupus familiaris (dog)PEPDXP_533702.2
Bos taurus (cattle)PEPDNP_001073787.2
Mus musculus (house mouse)PepdNP_032846.2
Rattus norvegicus (Norway rat)PepdNP_001009641.1
Gallus gallus (chicken)PEPDNP_001073185.1
Danio rerio (zebrafish)pepdNP_944594.1
Drosophila melanogaster (fruit fly)Dip-CNP_650192.1
Caenorhabditis elegansK12C11.1NP_490843.1
Arabidopsis thaliana (thale cress)AT4G29490NP_194678.2
Xenopus (Silurana) tropicalis (western clawed frog)pepdNP_001008094.1
GO:0006520cellular amino acid metabolic processTAS
GO:0030574collagen catabolic processIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0004177aminopeptidase activityIEA
GO:0004181metallocarboxypeptidase activityTAS
GO:0016805dipeptidase activityIEA
GO:0030145manganese ion bindingIEA
GeneCards PEPD
UniProt P12955
Vega OTTHUMG00000180470
MIM 613230
Ensembl ENSG00000124299
HGNC 8840
HPRD 01358

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PEPD gene?

The PEPD gene provides instructions for making the enzyme prolidase, also called peptidase D. Prolidase helps divide certain dipeptides, which are molecules composed of two protein building blocks (amino acids). Specifically, prolidase divides dipeptides containing the amino acids proline or hydroxyproline. By freeing these amino acids, prolidase helps make them available for use in producing proteins that the body needs.

Prolidase is also involved in the final step of the breakdown of some proteins obtained though the diet and proteins that are no longer needed in the body. Prolidase is particularly important in the breakdown of collagens, a family of proteins that are rich in proline and hydroxyproline. Collagens are an important part of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. The extracellular matrix strengthens and supports connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Collagen breakdown occurs during the maintenance (remodeling) of the extracellular matrix.


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