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PEPD peptidase D [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000285 Homo sapiens peptidase D (PEPD), transcript variant 1, mRNA. ORF Sequence $429.78
Peptide Services
Antibody Services
Protein Services
NM_001166056 Homo sapiens peptidase D (PEPD), transcript variant 2, mRNA. ORF Sequence $394.11
Peptide Services
Antibody Services
Protein Services
NM_001166057 Homo sapiens peptidase D (PEPD), transcript variant 3, mRNA. ORF Sequence $374.10
Peptide Services
Antibody Services
Protein Services


Gene Symbol PEPD
Entrez Gene ID 5184
Full Name peptidase D
Synonyms MGC10905, PROLIDASE
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.11

Summary This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Disorder

MIM: 613230

Prolidase deficiency, 170100 (3)

mRNA Protein Product Sequence Price Select
NM_000285, 260593661 NP_000276, 149589008 xaa-Pro dipeptidase isoform 1 Full Length $585.51
ORF Sequence $429.78
NM_001166056, 260593662 NP_001159528, 260593663 xaa-Pro dipeptidase isoform 2 Full Length $549.84
ORF Sequence $394.11
NM_001166057, 260593664 NP_001159529, 260593665 xaa-Pro dipeptidase isoform 3 Full Length $529.83
ORF Sequence $374.10
Homo sapiens (human)PEPDNP_000276.2
Pan troglodytes (chimpanzee)PEPDXP_512574.3
Canis lupus familiaris (dog)PEPDXP_533702.2
Bos taurus (cattle)PEPDNP_001073787.2
Mus musculus (house mouse)PepdNP_032846.2
Rattus norvegicus (Norway rat)PepdNP_001009641.1
Gallus gallus (chicken)PEPDNP_001073185.1
Danio rerio (zebrafish)pepdNP_944594.1
Drosophila melanogaster (fruit fly)Dip-CNP_650192.1
Caenorhabditis elegansK12C11.1NP_490843.1
Arabidopsis thaliana (thale cress)AT4G29490NP_194678.2
GeneCards PEPD
PDB 2OKN, 2IW2
UniProt P12955
MIM 613230
Ensembl ENSG00000124299
HGNC 8840
HPRD 01358

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
xaa-Pro dipeptidase
Names
xaa-Pro dipeptidase
imidodipeptidase
X-Pro dipeptidase
proline dipeptidase
aminoacyl-L-proline hydrolase
NP_000276.2
NP_001159528.1
NP_001159529.1

Interactant

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