Sequence in raw or FASTA format:
PEPD peptidase D [Homo sapiens (human)]
|Entrez Gene ID||5184|
|Full Name||peptidase D|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].|
Prolidase deficiency, 170100 (3)
|Homo sapiens (human)||PEPD||NP_000276.2|
|Pan troglodytes (chimpanzee)||PEPD||XP_512574.3|
|Macaca mulatta (Rhesus monkey)||PEPD||XP_001108725.2|
|Canis lupus familiaris (dog)||PEPD||XP_533702.2|
|Bos taurus (cattle)||PEPD||NP_001073787.2|
|Mus musculus (house mouse)||Pepd||NP_032846.2|
|Rattus norvegicus (Norway rat)||Pepd||NP_001009641.1|
|Gallus gallus (chicken)||PEPD||NP_001073185.1|
|Danio rerio (zebrafish)||pepd||NP_944594.1|
|Drosophila melanogaster (fruit fly)||Dip-C||NP_650192.1|
|Arabidopsis thaliana (thale cress)||AT4G29490||NP_194678.2|
|Xenopus (Silurana) tropicalis (western clawed frog)||pepd||NP_001008094.1|
|GO:0006520||cellular amino acid metabolic process||TAS|
|GO:0030574||collagen catabolic process||IEA|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0030145||manganese ion binding||IEA|
What is the normal function of the PEPD gene?
The PEPD gene provides instructions for making the enzyme prolidase, also called peptidase D. Prolidase helps divide certain dipeptides, which are molecules composed of two protein building blocks (amino acids). Specifically, prolidase divides dipeptides containing the amino acids proline or hydroxyproline. By freeing these amino acids, prolidase helps make them available for use in producing proteins that the body needs.
Prolidase is also involved in the final step of the breakdown of some proteins obtained though the diet and proteins that are no longer needed in the body. Prolidase is particularly important in the breakdown of collagens, a family of proteins that are rich in proline and hydroxyproline. Collagens are an important part of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. The extracellular matrix strengthens and supports connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Collagen breakdown occurs during the maintenance (remodeling) of the extracellular matrix.
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