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PF4 platelet factor 4 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_002619 Homo sapiens platelet factor 4 (PF4), mRNA. Full Length $159.00
ORF Sequence $159.00


Gene Symbol PF4
Entrez Gene ID 5196
Full Name platelet factor 4
Synonyms CXCL4, MGC138298, SCYB4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12-q21
Summary Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM].
Disorder

MIM: 173460
mRNA NM_002619, 194097423
Protein NP_002610, 4505733
Product platelet factor 4 precursor
RefSeq Status VALIDATED
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Pathway Interaction Database
cxcr3pathwayCXCR3-mediated signaling events
Reactome
REACT_21340GPCR ligand binding
REACT_19184GPCR downstream signaling
REACT_798Platelet Activation
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14819Peptide ligand-binding receptors
REACT_1439Common Pathway
REACT_19231G alpha (i) signalling events
REACT_20Formation of Platelet plug
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_15344Chemokine receptors bind chemokines
REACT_12051Cell surface interactions at the vascular wall
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_604Hemostasis
REACT_14797Signaling by GPCR
Homo sapiens (human)PF4NP_002610.1
Pan troglodytes (chimpanzee)PF4XP_001155980.1
Bos taurus (cattle)PF4NP_001094532.1
Mus musculus (house mouse)Pf4NP_064316.1
Rattus norvegicus (Norway rat)Pf4NP_001007730.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0006935chemotaxisIEA
GO:0006955immune responseIEA
GO:0007596blood coagulationTAS
GO:0010628positive regulation of gene expressionIDA
GO:0010744positive regulation of macrophage derived foam cell differentiationIDA
GO:0016525negative regulation of angiogenesisIDA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030168platelet activationIDA
GO:0030168platelet activationTAS
GO:0030595leukocyte chemotaxisIDA
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0043066negative regulation of apoptosisIDA
GO:0045347negative regulation of MHC class II biosynthetic processIDA
GO:0045651positive regulation of macrophage differentiationIDA
GO:0045653negative regulation of megakaryocyte differentiationIDA
GO:0045918negative regulation of cytolysisIDA
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005576extracellular regionIC
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0008009chemokine activityTAS
GO:0008201heparin bindingIDA
GeneCards PF4
PDB 1PFN, 1F9S, 1DN3, 1PFM, 1RHP, 1F9Q, 1F9R
UniProt P02776
MIM 173460
Ensembl ENSG00000163737
HGNC 8861
HPRD 01426

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