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PF4 platelet factor 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002619 Homo sapiens platelet factor 4 (PF4), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
XM_005265696 PREDICTED: Homo sapiens platelet factor 4 (PF4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $299.00 14

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Gene Symbol PF4
Entrez Gene ID 5196
Full Name platelet factor 4
Synonyms CXCL4, PF-4, SCYB4
General protein information
Preferred Names
platelet factor 4
Names
platelet factor 4
iroplact
oncostatin-A
C-X-C motif chemokine 4
chemokine (C-X-C motif) ligand 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12-q21

Summary This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012].
Disorder

MIM: 173460

mRNA Protein Product Sequence Price Select
NM_002619, 380254445 NP_002610, 4505733 platelet factor 4 precursor ORF Sequence $99.00
XM_005265696, 530376992 XP_005265753, 530376993 platelet factor 4 isoform X1 ORF Sequence $150.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Pathway Interaction Database
cxcr3pathwayCXCR3-mediated signaling events
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_12051Cell surface interactions at the vascular wall
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_15344Chemokine receptors bind chemokines
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)PF4NP_002610.1
Pan troglodytes (chimpanzee)PF4XP_001155980.1
Macaca mulatta (Rhesus monkey)PF4XP_001102788.1
Bos taurus (cattle)PF4NP_001094532.1
Mus musculus (house mouse)Pf4NP_064316.1
Rattus norvegicus (Norway rat)Pf4NP_001007730.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0006955immune responseIEA
GO:0007596blood coagulationTAS
GO:0010628positive regulation of gene expressionIDA
GO:0010744positive regulation of macrophage derived foam cell differentiationIDA
GO:0016525negative regulation of angiogenesisIDA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030168platelet activationIDA
GO:0030168platelet activationTAS
GO:0030595leukocyte chemotaxisIDA
GO:0030816positive regulation of cAMP metabolic processIDA
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0042127regulation of cell proliferationIDA
GO:0043950positive regulation of cAMP-mediated signalingIDA
GO:0045347negative regulation of MHC class II biosynthetic processIDA
GO:0045651positive regulation of macrophage differentiationIDA
GO:0045653negative regulation of megakaryocyte differentiationIDA
GO:0045918negative regulation of cytolysisIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDA
Component
IDNameEvidence
GO:0005576extracellular regionIC
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0008009chemokine activityTAS
GO:0008201heparin bindingIDA
GO:0048248CXCR3 chemokine receptor bindingIDA
GeneCards PF4
PDB 1PFN, 1F9S, 1DN3, 1PFM, 1RHP, 1F9Q, 1F9R
UniProt P02776
MIM 173460
HGNC 8861
HPRD 01426

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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