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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PFKM phosphofructokinase, muscle [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28127 NM_001166686 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28128 NM_001166687 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu28128 NM_000289 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 4, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu28128 NM_001166688 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu46638 XM_005268974 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu46638 XM_005268975 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu46638 XM_005268976 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28127 XM_005268977 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28127 XM_005268978 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28127 XM_005268979 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu46639 XM_005268980 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28128 XM_006719463 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X8, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28128 XM_006719464 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X9, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu28127C NM_001166686 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu28128C NM_001166687 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu28128C NM_000289 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 4, mRNA. Customized vector In-stock 5-7 $149.00
OHu28128C NM_001166688 Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu46638C XM_005268974 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu46638C XM_005268975 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu46638C XM_005268976 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu28127C XM_005268977 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu28127C XM_005268978 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X5, mRNA. Customized vector On-demand 12-14 $329.00
OHu28127C XM_005268979 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00
OHu46639C XM_005268980 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X7, mRNA. Customized vector On-demand 12-14 $329.00
OHu28128C XM_006719463 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X8, mRNA. Customized vector On-demand 12-14 $329.00
OHu28128C XM_006719464 PREDICTED: Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant X9, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol PFKM
Entrez Gene ID 5213
Full Name phosphofructokinase, muscle
Synonyms GSD7, PFK-1, PFK1, PFKA, PFKX, PPP1R122
General protein information
Preferred Names
6-phosphofructokinase, muscle type
Names
6-phosphofructokinase, muscle type
PFK-A
phosphohexokinase
phosphofructokinase 1
phosphofructokinase-M
6-phosphofructo-1-kinase
phosphofructo-1-kinase isozyme A
phosphofructokinase, polypeptide X
NP_000280.1
NP_001160158.1
NP_001160159.1
NP_001160160.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13.3

Summary Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009].
Disorder

MIM: 610681

Glycogen storage disease VII, 232800 (3)

mRNA Protein Product Sequence Price Select
NM_000289, 266453668 NP_000280, 4505749 6-phosphofructokinase, muscle type isoform 2 ORF Sequence $660.00
NM_001166686, 266453618 NP_001160158, 266453619 6-phosphofructokinase, muscle type isoform 1 ORF Sequence $750.00
NM_001166687, 266453747 NP_001160159, 266453748 6-phosphofructokinase, muscle type isoform 2 ORF Sequence $660.00
NM_001166688, 266453767 NP_001160160, 266453768 6-phosphofructokinase, muscle type isoform 2 ORF Sequence $660.00
XM_005268974, 530400461 XP_005269031, 530400462 6-phosphofructokinase, muscle type isoform X1 ORF Sequence $750.00
XM_005268975, 530400463 XP_005269032, 530400464 6-phosphofructokinase, muscle type isoform X2 ORF Sequence $750.00
XM_005268976, 530400465 XP_005269033, 530400466 6-phosphofructokinase, muscle type isoform X3 ORF Sequence $750.00
XM_005268977, 530400467 XP_005269034, 530400468 6-phosphofructokinase, muscle type isoform X4 ORF Sequence $750.00
XM_005268978, 578823891 XP_005269035, 530400470 6-phosphofructokinase, muscle type isoform X5 ORF Sequence $750.00
XM_005268979, 530400471 XP_005269036, 530400472 6-phosphofructokinase, muscle type isoform X6 ORF Sequence $750.00
XM_005268980, 530400473 XP_005269037, 530400474 6-phosphofructokinase, muscle type isoform X7 ORF Sequence $750.00
XM_006719463, 578823892 XP_006719526, 578823893 6-phosphofructokinase, muscle type isoform X8 ORF Sequence $750.00
XM_006719464, 578823894 XP_006719527, 578823895 6-phosphofructokinase, muscle type isoform X9 ORF Sequence $750.00
KEGG
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
hsa04152AMPK signaling pathway
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP481Insulin Signaling
Pathway Interaction Database
myc_activpathwayValidated targets of C-MYC transcriptional activation
BIOCYC
META_ANAEROFRUCAT-PWYhomolactic fermentation
HUMAN_GLYCOLYSISglycolysis I
META_PWY66-400glycolysis VI (metazoan)
Reactome
REACT_1383Glycolysis
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)PFKMNP_001160158.1
Pan troglodytes (chimpanzee)PFKMXP_509029.2
Macaca mulatta (Rhesus monkey)PFKMXP_001096244.1
Canis lupus familiaris (dog)PFKMNP_001003199.1
Bos taurus (cattle)PFKMNP_001068736.1
Mus musculus (house mouse)PfkmNP_067489.3
Rattus norvegicus (Norway rat)PfkmNP_113903.1
Gallus gallus (chicken)PFKMNP_989554.2
Danio rerio (zebrafish)pfkmbNP_001082886.1
Danio rerio (zebrafish)pfkmaNP_001004575.1
Drosophila melanogaster (fruit fly)PfkNP_724891.2
Caenorhabditis elegansY71H10A.1NP_741738.1
Xenopus (Silurana) tropicalis (western clawed frog)pfkmXP_004911968.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006002fructose 6-phosphate metabolic processIDA
GO:0006002fructose 6-phosphate metabolic processIMP
GO:0006006glucose metabolic processTAS
GO:0006096glycolytic processIEA
GO:0006096glycolytic processIMP
GO:0006096glycolytic processTAS
GO:0032024positive regulation of insulin secretionIEA
GO:0042593glucose homeostasisIEA
GO:0044281small molecule metabolic processTAS
GO:0046716muscle cell cellular homeostasisIMP
GO:0046835carbohydrate phosphorylationIDA
GO:0046835carbohydrate phosphorylationIEA
GO:0046835carbohydrate phosphorylationIMP
GO:0046835carbohydrate phosphorylationISS
GO:0051259protein oligomerizationIDA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:00059456-phosphofructokinase complexIDA
GO:0016324apical plasma membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:00038726-phosphofructokinase activityIDA
GO:00038726-phosphofructokinase activityIMP
GO:00038726-phosphofructokinase activityISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0008022protein C-terminus bindingIPI
GO:0019900kinase bindingIPI
GO:0042802identical protein bindingIPI
GO:0046872metal ion bindingIEA
GO:0070061fructose bindingIDA
GeneCards PFKM
UniProt P08237
Vega OTTHUMG00000169898
MIM 610681
Ensembl ENSG00000152556
HGNC 8877
HPRD 01988

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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