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PGAM2 phosphoglycerate mutase 2 (muscle) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19214 NM_000290 Homo sapiens phosphoglycerate mutase 2 (muscle) (PGAM2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19214C NM_000290 Homo sapiens phosphoglycerate mutase 2 (muscle) (PGAM2), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PGAM2
Entrez Gene ID 5224
Full Name phosphoglycerate mutase 2 (muscle)
Synonyms GSD10, PGAM-M, PGAMM
General protein information
Preferred Names
phosphoglycerate mutase 2
Names
phosphoglycerate mutase 2
BPG-dependent PGAM 2
phosphoglycerate mutase isozyme M
muscle-specific phosphoglycerate mutase
NP_000281.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p13-p12

Summary Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009].
Disorder

MIM: 612931

Glycogen storage disease X, 261670 (3)

mRNA Protein Product Sequence Price Select
NM_000290, 259490363 NP_000281, 50593010 phosphoglycerate mutase 2 ORF Sequence $199.00
KEGG
hsa00010Glycolysis / Gluconeogenesis
hsa00260Glycine, serine and threonine metabolism
hsa_M00003Gluconeogenesis, oxaloacetate => fructose-6P
hsa_M00002Glycolysis, core module involving three-carbon compounds
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
BIOCYC
META_ANAEROFRUCAT-PWYhomolactic fermentation
HUMAN_GLUCONEO-PWYgluconeogenesis I
HUMAN_GLYCOLYSISglycolysis I
HUMAN_PWY-6405Rapoport-Luebering glycolytic shunt
META_PWY-6405Rapoport-Luebering glycolytic shunt
META_PWY66-400glycolysis VI (metazoan)
META_PWY66-399gluconeogenesis III
Reactome
REACT_1383Glycolysis
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_1520Gluconeogenesis
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)PGAM2NP_000281.2
Pan troglodytes (chimpanzee)PGAM2XP_001143059.1
Macaca mulatta (Rhesus monkey)PGAM2XP_001116220.1
Canis lupus familiaris (dog)PGAM2XP_532718.2
Bos taurus (cattle)PGAM2NP_001033200.1
Mus musculus (house mouse)Pgam2NP_061358.1
Rattus norvegicus (Norway rat)Pgam2NP_059024.1
Danio rerio (zebrafish)pgam2NP_957318.1
Drosophila melanogaster (fruit fly)Pglym87NP_652041.2
Xenopus (Silurana) tropicalis (western clawed frog)pgam2NP_001005665.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006096glycolytic processIMP
GO:0006096glycolytic processTAS
GO:0006941striated muscle contractionIMP
GO:0007283spermatogenesisIEA
GO:0016311dephosphorylationIEA
GO:0044281small molecule metabolic processTAS
GO:0046689response to mercury ionIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004082bisphosphoglycerate mutase activityIEA
GO:0004083bisphosphoglycerate 2-phosphatase activityIEA
GO:0004619phosphoglycerate mutase activityIMP
GO:00465382,3-bisphosphoglycerate-dependent phosphoglycerate mutase activityIEA
GO:0048037cofactor bindingIEA
GeneCards PGAM2
UniProt P15259
Vega OTTHUMG00000155355
MIM 612931
Ensembl ENSG00000164708
HGNC 8889
HPRD 02027

Interactant

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