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PGK1 phosphoglycerate kinase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000291 Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol PGK1
Entrez Gene ID 5230
Full Name phosphoglycerate kinase 1
Synonyms HEL-S-68p, MIG10, PGKA
General protein information
Preferred Names
phosphoglycerate kinase 1
Names
phosphoglycerate kinase 1
PRP 2
primer recognition protein 2
cell migration-inducing gene 10 protein
NP_000282.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq13.3

Summary The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014].
Disorder

MIM: 311800

Phosphoglycerate kinase 1 deficiency, 300653 (3)

mRNA Protein Product Sequence Price Select
NM_000291, 183603937 NP_000282, 4505763 phosphoglycerate kinase 1 ORF Sequence $360.00
KEGG
hsa00010Glycolysis / Gluconeogenesis
hsa_M00003Gluconeogenesis, oxaloacetate => fructose-6P
hsa_M00002Glycolysis, core module involving three-carbon compounds
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa04066HIF-1 signaling pathway
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
Pathway Interaction Database
hif2pathwayHIF-2-alpha transcription factor network
hif1_tfpathwayHIF-1-alpha transcription factor network
BIOCYC
META_ANAEROFRUCAT-PWYhomolactic fermentation
HUMAN_GLUCONEO-PWYgluconeogenesis I
HUMAN_GLYCOLYSISglycolysis I
META_PWY66-400glycolysis VI (metazoan)
META_PWY66-399gluconeogenesis III
Reactome
REACT_1383Glycolysis
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_1520Gluconeogenesis
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)PGK1NP_000282.1
Pan troglodytes (chimpanzee)PGK1NP_001129210.1
Macaca mulatta (Rhesus monkey)PGK1XP_001100787.1
Canis lupus familiaris (dog)PGK1XP_849992.1
Bos taurus (cattle)PGK1NP_001029471.1
Mus musculus (house mouse)Pgk1NP_032854.2
Rattus norvegicus (Norway rat)Pgk1NP_445743.2
Gallus gallus (chicken)PGK1NP_990316.1
Danio rerio (zebrafish)pgk1NP_998552.1
Drosophila melanogaster (fruit fly)PgkNP_001259958.1
Caenorhabditis eleganspgk-1NP_491245.1
Arabidopsis thaliana (thale cress)PGK1NP_187884.1
Arabidopsis thaliana (thale cress)AT1G56190NP_176015.1
Xenopus (Silurana) tropicalis (western clawed frog)pgk1NP_001016545.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006096glycolytic processIEA
GO:0006096glycolytic processTAS
GO:0016310phosphorylationISS
GO:0030855epithelial cell differentiationIEP
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0016020membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004618phosphoglycerate kinase activityEXP
GO:0004618phosphoglycerate kinase activityISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingISS
GeneCards PGK1
PDB 4AXX, 2Y3I, 2XE6, 2WZC, 2WZD, 3C3C, 3ZOZ, 2ZGV, 2X13, 2XE8, 3C3B, 2XE7, 2WZB, 2X15, 2X14, 3C39, 2YBE, 3C3A
UniProt P00558, V9HWF4
MIM 311800
Ensembl ENSG00000102144
HGNC 8896
HPRD 02412

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PGK1 gene?

The PGK1 gene provides instructions for making an enzyme called phosphoglycerate kinase. This enzyme is found in cells and tissues throughout the body, where it is involved in a critical energy-producing process known as glycolysis. During glycolysis, the simple sugar glucose is broken down to produce energy.

Phosphoglycerate kinase helps carry out a chemical reaction that converts a molecule called 1,3-diphosphoglycerate, which is produced during the breakdown of glucose, to another molecule called 3-phosphoglycerate. This reaction generates one molecule of adenosine triphosphate (ATP), which is the main energy source in cells.

Researchers suspect that phosphoglycerate kinase may have additional functions, although little is known about the other roles this enzyme may play in cells.

Interactant

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