PHKA2 phosphorylase kinase, alpha 2 (liver) [Homo sapiens (human)]
| Gene Symbol | PHKA2 |
| Entrez Gene ID | 5256 |
| Full Name | phosphorylase kinase, alpha 2 (liver) |
| Synonyms | GSD9A, MGC133071, PHK, PYK, PYKL, XLG, XLG2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
X Xp22.2-p22.1 |
| Summary | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined. |
| Disorder | MIM: 300798 Glycogen storage disease, type IXa1, 306000 (3); Glycogen storage |
| mRNA | NM_000292, 169790834 |
| Protein | NP_000283, 4505781 |
| Product | phosphorylase b kinase regulatory subunit alpha, liver isoform |
| RefSeq Status | REVIEWED |
| hsa04910 | Insulin signaling pathway |
| hsa04020 | Calcium signaling pathway |
WikiPathways
| WP500 | Glycogen Metabolism |
Reactome
| REACT_723 | Glucose metabolism |
| REACT_474 | Metabolism of carbohydrates |
| REACT_1008 | Glycogen breakdown (glycogenolysis) |
| Homo sapiens (human) | PHKA2 | NP_000283.1 |
| Canis lupus familiaris (dog) | PHKA2 | XP_537974.2 |
| Mus musculus (house mouse) | Phka2 | NP_766371.1 |
| Rattus norvegicus (Norway rat) | Phka2 | XP_001053211.1 |
| Gallus gallus (chicken) | PHKA2 | XP_416811.2 |
| Danio rerio (zebrafish) | LOC556199 | XP_684044.3 |
| Drosophila melanogaster (fruit fly) | CG7766 | NP_788889.2 |
| Caenorhabditis elegans | C14B9.8 | NP_498777.2 |
| ID | Name | Evidence |
| GO:0005975 | carbohydrate metabolic process | TAS |
| GO:0005976 | polysaccharide metabolic process | IEA |
| GO:0005980 | glycogen catabolic process | TAS |
| GO:0006006 | glucose metabolic process | TAS |
| GO:0006091 | generation of precursor metabolites and energy | TAS |
| GO:0006464 | protein modification process | TAS |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | IEA |
| GO:0005964 | phosphorylase kinase complex | TAS |
Function
| ID | Name | Evidence |
| GO:0003824 | catalytic activity | IEA |
| GO:0004339 | glucan 1,4-alpha-glucosidase activity | IEA |
| GO:0004689 | phosphorylase kinase activity | TAS |
| GO:0005516 | calmodulin binding | IEA |
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