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SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000295 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 1, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001002235 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 3, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001002236 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 2, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127700 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 4, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127701 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 5, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127702 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 6, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127703 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 7, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127704 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 8, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127705 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 9, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127706 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 10, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services
NM_001127707 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 11, mRNA. ORF Sequence $364.53
Peptide Services
Antibody Services
Protein Services


Gene Symbol SERPINA1
Entrez Gene ID 5265
Full Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Synonyms A1A, A1AT, AAT, MGC23330, MGC9222, PI, PI1, PRO2275, alpha1AT
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.1

Summary The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 107400

Emphysema due to AAT deficiency, 613490 (3); Emphysema-cirrhosis, due

mRNA Protein Product Sequence Price Select
NM_000295, 189163524 NP_000286, 50363217 alpha-1-antitrypsin precursor Full Length $1127.00
ORF Sequence $364.53
NM_001002235, 189163525 NP_001002235, 50363221 alpha-1-antitrypsin precursor Full Length $1119.65
ORF Sequence $364.53
NM_001002236, 189163526 NP_001002236, 50363219 alpha-1-antitrypsin precursor Full Length $1229.55
ORF Sequence $364.53
NM_001127700, 189163527 NP_001121172, 189163528 alpha-1-antitrypsin precursor Full Length $1132.60
ORF Sequence $364.53
NM_001127701, 189163529 NP_001121173, 189163530 alpha-1-antitrypsin precursor Full Length $1236.20
ORF Sequence $364.53
NM_001127702, 189163531 NP_001121174, 189163532 alpha-1-antitrypsin precursor Full Length $1169.00
ORF Sequence $364.53
NM_001127703, 189163533 NP_001121175, 189163534 alpha-1-antitrypsin precursor Full Length $1223.25
ORF Sequence $364.53
NM_001127704, 189163535 NP_001121176, 189163536 alpha-1-antitrypsin precursor Full Length $1222.20
ORF Sequence $364.53
NM_001127705, 189163537 NP_001121177, 189163538 alpha-1-antitrypsin precursor Full Length $1228.50
ORF Sequence $364.53
NM_001127706, 189163539 NP_001121178, 189163540 alpha-1-antitrypsin precursor Full Length $1156.05
ORF Sequence $364.53
NM_001127707, 189163541 NP_001121179, 189163542 alpha-1-antitrypsin precursor Full Length $1155.00
ORF Sequence $364.53
KEGG
hsa04610Complement and coagulation cascades
Pathway Interaction Database
hnf3apathwayFOXA1 transcription factor network
WikiPathways
WP558Complement and Coagulation Cascades
Reactome
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
Homo sapiens (human)SERPINA1NP_001121179.1
Pan troglodytes (chimpanzee)SERPINA1XP_003314544.1
Macaca mulatta (Rhesus monkey)SERPINA1XP_001099044.1
Canis lupus familiaris (dog)SERPINA1NP_001073578.1
Bos taurus (cattle)SERPINA1NP_776307.1
Mus musculus (house mouse)Serpina1eNP_033273.1
Mus musculus (house mouse)Serpina1aNP_001239498.1
Mus musculus (house mouse)Serpina1cNP_033271.1
Mus musculus (house mouse)Serpina1bNP_033270.3
Mus musculus (house mouse)Serpina1dNP_033272.1
Rattus norvegicus (Norway rat)Serpina1NP_071964.2
Gallus gallus (chicken)SERPINA4XP_421342.2
Gallus gallus (chicken)SERPINA3XP_001235490.1
Gallus gallus (chicken)SERPINA9XP_421345.1
Gallus gallus (chicken)SERPINA5XP_421344.1
Gallus gallus (chicken)SERPINA1XP_421343.3
Danio rerio (zebrafish)serpina1lNP_001013277.3
Danio rerio (zebrafish)serpina1NP_001071226.1
GeneCards SERPINA1
PDB 1EZX, 1HP7, 1QMB, 3CWM, 9API, 3NDD, 1ATU, 3DRM, 1QLP, 1KCT, 3T1P, 3DRU, 2D26, 1PSI, 3NE4, 1D5S, 2QUG, 8API, 7API, 3CWL, 1IZ2, 3NDF, 1OPH, 1OO8
UniProt E9KL23, P01009
MIM 107400
Ensembl ENSG00000197249
HGNC 8941
HPRD 02463

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
alpha-1-antitrypsin
Names
alpha-1-antitrypsin
serpin A1
alpha-1-antiproteinase
alpha-1-antitrypsin null
alpha-1 protease inhibitor
protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
serine (or cysteine) proteinase inhibitor, clade A, member 1

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