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PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001242466 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_181504 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_181523 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181524 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol PIK3R1
Entrez Gene ID 5295
Full Name phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Synonyms GRB1, p85, p85-ALPHA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q13.1

Summary Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
Disorder

MIM: 171833

mRNA Protein Product Sequence Price Select
NM_001242466, 335057533 NP_001229395, 335057534 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4 ORF Sequence $269.00
NM_181504, 335057532 NP_852556, 32455252 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 ORF Sequence $550.00
NM_181523, 335057530 NP_852664, 32455248 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 ORF Sequence $700.00
NM_181524, 32455249 NP_852665, 32455250 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3 ORF Sequence $550.00
KEGG
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
hsa04380Osteoclast differentiation
hsa05223Non-small cell lung cancer
hsa05166HTLV-I infection
hsa04666Fc gamma R-mediated phagocytosis
hsa05210Colorectal cancer
hsa04930Type II diabetes mellitus
hsa04012ErbB signaling pathway
hsa05222Small cell lung cancer
hsa05215Prostate cancer
hsa05169Epstein-Barr virus infection
hsa04722Neurotrophin signaling pathway
hsa04510Focal adhesion
hsa05146Amoebiasis
hsa05203Viral carcinogenesis
hsa04650Natural killer cell mediated cytotoxicity
hsa04210Apoptosis
hsa04960Aldosterone-regulated sodium reabsorption
hsa04914Progesterone-mediated oocyte maturation
hsa05212Pancreatic cancer
hsa05214Glioma
hsa04070Phosphatidylinositol signaling system
hsa04150mTOR signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04662B cell receptor signaling pathway
hsa05213Endometrial cancer
hsa04620Toll-like receptor signaling pathway
hsa04066HIF-1 signaling pathway
hsa05221Acute myeloid leukemia
hsa04670Leukocyte transendothelial migration
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa04660T cell receptor signaling pathway
hsa04725Cholinergic synapse
hsa04973Carbohydrate digestion and absorption
hsa05160Hepatitis C
hsa04370VEGF signaling pathway
hsa05164Influenza A
hsa04810Regulation of actin cytoskeleton
hsa04664Fc epsilon RI signaling pathway
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05220Chronic myeloid leukemia
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05161Hepatitis B
hsa05162Measles
WikiPathways
WP127IL-5 Signaling Pathway
WP61Delta-Notch Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
WP75Toll-like receptor signaling pathway
WP395IL-4 signaling Pathway
WP138Androgen receptor signaling pathway
WP2332Interleukin-11 Signaling Pathway
WP69TCR Signaling Pathway
WP481Insulin Signaling
WP304Kit Receptor Signaling Pathway
WP306Focal Adhesion
WP49IL-2 Signaling Pathway
WP51Regulation of Actin Cytoskeleton
WP1403AMPK signaling
WP286IL-3 Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP22IL-9 Signaling Pathway
WP2034Leptin signaling pathway
WP254Apoptosis
WP2018RANKL/RANK Signaling Pathway
WP2037Prolactin Signaling Pathway
WP437EGFR1 Signaling Pathway
WP2032TSH signaling pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP205IL-7 Signaling Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP364IL-6 Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP2374Oncostatin M Signaling Pathway
Pathway Interaction Database
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
insulin_pathwayInsulin Pathway
faspathwayFAS (CD95) signaling pathway
p75ntrpathwayp75(NTR)-mediated signaling
a4b1_paxindep_pathwayPaxillin-independent events mediated by a4b1 and a4b7
a4b1_paxdep_pathwayPaxillin-dependent events mediated by a4b1
ecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
ncadherinpathwayN-cadherin signaling events
il2_pi3kpathwayIL2 signaling events mediated by PI3K
il2_1pathwayIL2-mediated signaling events
lysophospholipid_pathwayLPA receptor mediated events
nectin_pathwayNectin adhesion pathway
vegfr1_pathwayVEGFR1 specific signals
fak_pathwaySignaling events mediated by focal adhesion kinase
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
cxcr4_pathwayCXCR4-mediated signaling events
ephrinbrevpathwayEphrin B reverse signaling
pdgfrbpathwayPDGFR-beta signaling pathway
il2_stat5pathwayIL2 signaling events mediated by STAT5
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
il4_2pathwayIL4-mediated signaling events
ephbfwdpathwayEPHB forward signaling
epha2_fwdpathwayEPHA2 forward signaling
ifngpathwayIFN-gamma pathway
epopathwayEPO signaling pathway
cxcr3pathwayCXCR3-mediated signaling events
trail_pathwayTRAIL signaling pathway
il1pathwayIL1-mediated signaling events
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
erbb1_internalization_pathwayInternalization of ErbB1
cdc42_pathwayCDC42 signaling events
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
lymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
avb3_integrin_pathwayIntegrins in angiogenesis
avb3_opn_pathwayOsteopontin-mediated events
igf1_pathwayIGF1 pathway
pdgfrapathwayPDGFR-alpha signaling pathway
bcr_5pathwayBCR signaling pathway
nfkappabatypicalpathwayAtypical NF-kappaB pathway
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
ptp1bpathwaySignaling events mediated by PTP1B
ret_pathwaySignaling events regulated by Ret tyrosine kinase
erbb2erbb3pathwayErbB2/ErbB3 signaling events
pi3kcipathwayClass I PI3K signaling events
fcer1pathwayFc-epsilon receptor I signaling in mast cells
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
tcptp_pathwaySignaling events mediated by TCPTP
hedgehog_2pathwaySignaling events mediated by the Hedgehog family
il23pathwayIL23-mediated signaling events
erbb1_downstream_pathwayErbB1 downstream signaling
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
reelinpathwayReelin signaling pathway
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
il6_7pathwayIL6-mediated signaling events
fgf_pathwayFGF signaling pathway
erbb4_pathwayErbB4 signaling events
ar_nongenomic_pathwayNongenotropic Androgen signaling
BIOCYC
HUMAN_PWY-6371superpathway of inositol phosphate compounds
HUMAN_PWY-63523-phosphoinositide biosynthesis
META_PWY-63523-phosphoinositide biosynthesis
Reactome
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_115596Signaling by ERBB4
REACT_12464PI3K/AKT activation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_120999Signaling by FGFR1 mutants
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_111155Cell-Cell communication
REACT_115529Interleukin-7 signaling
REACT_147694DAP12 interactions
REACT_115852Signaling by constitutively active EGFR
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_22232Signaling by Interleukins
REACT_762IRS-related events
REACT_332IRS-mediated signalling
REACT_120870Phospholipid metabolism
REACT_23832Nephrin interactions
REACT_121398Signaling by FGFR mutants
REACT_9470Signaling by FGFR
REACT_121141Signaling by FGFR1 fusion mutants
REACT_16888Signaling by PDGF
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115755Signaling by ERBB2
REACT_12578GAB1 signalosome
REACT_23891Interleukin receptor SHC signaling
REACT_798Platelet activation, signaling and aggregation
REACT_116125Disease
REACT_18407G alpha (12/13) signalling events
REACT_23847GP1b-IX-V activation signalling
REACT_115961PI3K events in ERBB4 signaling
REACT_17025Downstream signal transduction
REACT_23787Regulation of signaling by CBL
REACT_111040Signaling by SCF-KIT
REACT_12621Tie2 Signaling
REACT_118700Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_21270PI-3K cascade
REACT_12555Downstream TCR signaling
REACT_21272Downstream signaling of activated FGFR
REACT_111102Signal Transduction
REACT_19344Costimulation by the CD28 family
REACT_22258Metabolism of lipids and lipoproteins
REACT_27283Interleukin-2 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_18283G alpha (q) signalling events
REACT_14797Signaling by GPCR
REACT_1695GPVI-mediated activation cascade
REACT_121175PI Metabolism
REACT_976PI3K Cascade
REACT_1195Insulin receptor signalling cascade
REACT_115871Signaling by EGFR in Cancer
REACT_75829PIP3 activates AKT signaling
REACT_604Hemostasis
REACT_498Signaling by Insulin receptor
REACT_120736Signaling by FGFR in disease
REACT_12526TCR signaling
REACT_111217Metabolism
REACT_147723PI3K/AKT Signaling in Cancer
REACT_12051Cell surface interactions at the vascular wall
REACT_19184GPCR downstream signaling
REACT_6802Innate Immune System
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_147814DAP12 signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_9417Signaling by EGFR
Homo sapiens (human)PIK3R1NP_852664.1
Pan troglodytes (chimpanzee)PIK3R1XP_517729.2
Macaca mulatta (Rhesus monkey)PIK3R1XP_001089423.1
Canis lupus familiaris (dog)PIK3R1XP_850341.1
Bos taurus (cattle)PIK3R1NP_777000.1
Mus musculus (house mouse)Pik3r1NP_001070963.1
Rattus norvegicus (Norway rat)Pik3r1NP_037137.1
Gallus gallus (chicken)PIK3R1XP_424759.1
Danio rerio (zebrafish)pik3r1XP_683819.3
Caenorhabditis elegansaap-1NP_491522.1
GeneCards PIK3R1
PDB 3I5R, 3HHM, 1H9O, 1A0N, 1PBW, 2IUI, 2IUG, 4A55, 2RD0, 3I5S, 2IUH, 2V1Y, 1PKT, 3HIZ, 1PHT, 1PKS, 1PIC, 1AZG
UniProt P27986
MIM 171833
Ensembl ENSG00000145675
HGNC 8979
HPRD 01381

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General protein information

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