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PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21135D NM_181524 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK On-demand 7-9 Starting from $99
OHu21143D NM_181523 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu21380D NM_001242466 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 4, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu25115D NM_181504 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK On-demand 7-9 Starting from $99
OHu21143D XM_005248542 PREDICTED: Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu21135C NM_181524 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 3, mRNA. Customized vector On-demand 7-9 Starting from $99
OHu21143C NM_181523 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 1, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu21380C NM_001242466 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 4, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu25115C NM_181504 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 2, mRNA. Customized vector On-demand 7-9 Starting from $99
OHu21143C XM_005248542 PREDICTED: Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant X1, mRNA. Customized vector In-stock 5-7 Starting from $99

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Mutation services

Gene Symbol PIK3R1
Entrez Gene ID 5295
Full Name phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Synonyms AGM7, GRB1, p85, p85-ALPHA
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

MIM: 171833

mRNA Protein Product Sequence Price Select
NM_001242466, 335057533 NP_001229395, 335057534 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4 ORF Sequence $269.00
NM_181504, 335057532 NP_852556, 32455252 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 ORF Sequence $550.00
NM_181523, 335057530 NP_852664, 32455248 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 ORF Sequence $700.00
NM_181524, 32455249 NP_852665, 32455250 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3 ORF Sequence $550.00
XM_005248542, 530379377 XP_005248599, 530379378 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 ORF Sequence $700.00
hsa04012ErbB signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04070Phosphatidylinositol signaling system
hsa04664Fc epsilon RI signaling pathway
hsa04150mTOR signaling pathway
hsa04370VEGF signaling pathway
hsa04662B cell receptor signaling pathway
hsa04910Insulin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04630Jak-STAT signaling pathway
hsa04930Type II diabetes mellitus
hsa04660T cell receptor signaling pathway
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa04620Toll-like receptor signaling pathway
hsa05212Pancreatic cancer
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa04670Leukocyte transendothelial migration
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05220Chronic myeloid leukemia
hsa05223Non-small cell lung cancer
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04666Fc gamma R-mediated phagocytosis
hsa05142Chagas disease (American trypanosomiasis)
hsa04973Carbohydrate digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa05160Hepatitis C
hsa05100Bacterial invasion of epithelial cells
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa04725Cholinergic synapse
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa05205Proteoglycans in cancer
hsa04915Estrogen signaling pathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa04668TNF signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04917Prolactin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04919Thyroid hormone signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04152AMPK signaling pathway
WP437EGFR1 Signaling Pathway
WP127IL-5 Signaling Pathway
WP138Androgen receptor signaling pathway
WP395IL-4 signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP304Kit Receptor Signaling Pathway
WP481Insulin Signaling
WP61Delta-Notch Signaling Pathway
WP286IL-3 Signaling Pathway
WP205IL-7 Signaling Pathway
WP22IL-9 Signaling Pathway
WP1403AMPK signaling
WP49IL-2 Signaling pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP51Regulation of Actin Cytoskeleton
WP364IL-6 Signaling Pathway
WP2332Interleukin-11 Signaling Pathway
WP2374Oncostatin M Signaling Pathway
WP2380BDNF signaling pathway
WP2034Leptin signaling pathway
WP2032TSH signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP2037Prolactin Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP1449Regulation of toll-like receptor signaling pathway
WP585Interferon type I
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
il6_7pathwayIL6-mediated signaling events
cxcr4_pathwayCXCR4-mediated signaling events
il1pathwayIL1-mediated signaling events
vegfr1_pathwayVEGFR1 specific signals
il2_pi3kpathwayIL2 signaling events mediated by PI3K
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
hedgehog_2pathwaySignaling events mediated by the Hedgehog family
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
avb3_integrin_pathwayIntegrins in angiogenesis
epha2_fwdpathwayEPHA2 forward signaling
il2_1pathwayIL2-mediated signaling events
erbb4_pathwayErbB4 signaling events
erbb2erbb3pathwayErbB2/ErbB3 signaling events
reelinpathwayReelin signaling pathway
ret_pathwaySignaling events regulated by Ret tyrosine kinase
trail_pathwayTRAIL signaling pathway
nfkappabatypicalpathwayAtypical NF-kappaB pathway
a4b1_paxindep_pathwayPaxillin-independent events mediated by a4b1 and a4b7
fgf_pathwayFGF signaling pathway
lymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
avb3_opn_pathwayOsteopontin-mediated events
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
igf1_pathwayIGF1 pathway
cdc42_pathwayCDC42 signaling events
il2_stat5pathwayIL2 signaling events mediated by STAT5
erbb1_internalization_pathwayInternalization of ErbB1
pi3kcipathwayClass I PI3K signaling events
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
il23pathwayIL23-mediated signaling events
ptp1bpathwaySignaling events mediated by PTP1B
ncadherinpathwayN-cadherin signaling events
il4_2pathwayIL4-mediated signaling events
a4b1_paxdep_pathwayPaxillin-dependent events mediated by a4b1
erbb1_downstream_pathwayErbB1 downstream signaling
ephbfwdpathwayEPHB forward signaling
pdgfrapathwayPDGFR-alpha signaling pathway
nectin_pathwayNectin adhesion pathway
faspathwayFAS (CD95) signaling pathway
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
ar_nongenomic_pathwayNongenotropic Androgen signaling
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
cxcr3pathwayCXCR3-mediated signaling events
insulin_pathwayInsulin Pathway
bcr_5pathwayBCR signaling pathway
ifngpathwayIFN-gamma pathway
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pdgfrbpathwayPDGFR-beta signaling pathway
ecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
p75ntrpathwayp75(NTR)-mediated signaling
epopathwayEPO signaling pathway
ephrinbrevpathwayEphrin B reverse signaling
fak_pathwaySignaling events mediated by focal adhesion kinase
tcptp_pathwaySignaling events mediated by TCPTP
HUMAN_PWY-63523-phosphoinositide biosynthesis
HUMAN_PWY-6371superpathway of inositol phosphate compounds
REACT_19184GPCR downstream signaling
REACT_19183CD28 co-stimulation
REACT_19344Costimulation by the CD28 family
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_1695GPVI-mediated activation cascade
REACT_12621Tie2 Signaling
REACT_12051Cell surface interactions at the vascular wall
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_12555Downstream TCR signaling
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12526TCR signaling
REACT_22232Signaling by Interleukins
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_22258Metabolism of lipids and lipoproteins
REACT_27283Interleukin-2 signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_75829PIP3 activates AKT signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23787Regulation of signaling by CBL
REACT_23832Nephrin interactions
REACT_23891Interleukin receptor SHC signaling
REACT_23847GP1b-IX-V activation signalling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_111155Cell-Cell communication
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_115529Interleukin-7 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_115852Signaling by constitutively active EGFR
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_120736Signaling by FGFR in disease
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_121141Signaling by FGFR1 fusion mutants
REACT_121175PI Metabolism
REACT_120870Phospholipid metabolism
REACT_121398Signaling by FGFR mutants
REACT_120999Signaling by FGFR1 mutants
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160158Role of phospholipids in phagocytosis
Homo sapiens (human)PIK3R1NP_852664.1
Pan troglodytes (chimpanzee)PIK3R1XP_517729.2
Macaca mulatta (Rhesus monkey)PIK3R1XP_001089423.1
Canis lupus familiaris (dog)PIK3R1XP_850341.1
Bos taurus (cattle)PIK3R1NP_777000.1
Mus musculus (house mouse)Pik3r1NP_001070963.1
Rattus norvegicus (Norway rat)Pik3r1NP_037137.1
Gallus gallus (chicken)PIK3R1XP_424759.1
Danio rerio (zebrafish)pik3r1XP_683819.3
Caenorhabditis elegansaap-1NP_491522.1
Xenopus (Silurana) tropicalis (western clawed frog)pik3r1XP_002934232.1
GO:0001953negative regulation of cell-matrix adhesionIEA
GO:0006468protein phosphorylationIEA
GO:0006644phospholipid metabolic processTAS
GO:0006661phosphatidylinositol biosynthetic processTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007596blood coagulationTAS
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIEA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIEA
GO:0014065phosphatidylinositol 3-kinase signalingIDA
GO:0016032viral processIEA
GO:0030168platelet activationTAS
GO:0030183B cell differentiationIEA
GO:0030335positive regulation of cell migrationIEA
GO:0031295T cell costimulationTAS
GO:0032760positive regulation of tumor necrosis factor productionIEA
GO:0034644cellular response to UVIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTAS
GO:0043066negative regulation of apoptotic processIEA
GO:0043551regulation of phosphatidylinositol 3-kinase activityISS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045671negative regulation of osteoclast differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046326positive regulation of glucose importISS
GO:0046854phosphatidylinositol phosphorylationISS
GO:0048009insulin-like growth factor receptor signaling pathwayIDA
GO:0048009insulin-like growth factor receptor signaling pathwayIPI
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0050852T cell receptor signaling pathwayTAS
GO:0050900leukocyte migrationTAS
GO:0051531NFAT protein import into nucleusIEA
GO:0060396growth hormone receptor signaling pathwayIDA
GO:0090004positive regulation of establishment of protein localization to plasma membraneISS
GO:0005886plasma membraneTAS
GO:0005942phosphatidylinositol 3-kinase complexISS
GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, class IA complexISS
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activityISS
GO:0005158insulin receptor bindingIPI
GO:0005159insulin-like growth factor receptor bindingIPI
GO:0005168neurotrophin TRKA receptor bindingIPI
GO:0005515protein bindingIPI
GO:0019903protein phosphatase bindingIPI
GO:0035014phosphatidylinositol 3-kinase regulator activityISS
GO:0043125ErbB-3 class receptor bindingIDA
GO:0043548phosphatidylinositol 3-kinase bindingISS
GO:0043559insulin bindingIDA
GO:0043560insulin receptor substrate bindingISS
GeneCards PIK3R1
UniProt P27986
Vega OTTHUMG00000131251
MIM 171833
Ensembl ENSG00000145675
HGNC 8979
HPRD 01381

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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