PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) [Homo sapiens (human)]
| Gene Symbol | PIN4 |
| Entrez Gene ID | 5303 |
| Full Name | protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) |
| Synonyms | EPVH, MGC138486, PAR14, PAR17 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
X Xq13 |
| Summary | This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq]. |
| Disorder | MIM: 300252 |
| mRNA | NM_006223, 282847474 |
| Protein | NP_006214, 38679892 |
| Product | peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001170747, 282847475 |
| Protein | NP_001164218, 282847476 |
| Product | peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | PIN4 | NP_006214.2 |
| Pan troglodytes (chimpanzee) | PIN4 | XP_001161176.1 |
| Canis lupus familiaris (dog) | PIN4 | XP_849005.1 |
| Mus musculus (house mouse) | Pin4 | NP_081457.1 |
| Mus musculus (house mouse) | Gm6851 | XP_897983.1 |
| Gallus gallus (chicken) | PIN4 | XP_420136.2 |
| Danio rerio (zebrafish) | zgc:110008 | NP_001018389.1 |
| Drosophila melanogaster (fruit fly) | CG11858 | NP_651364.1 |
| Caenorhabditis elegans | Y48C3A.16 | NP_496824.1 |
| Arabidopsis thaliana (thale cress) | AT1G26550 | NP_564250.1 |
| ID | Name | Evidence |
| GO:0006364 | rRNA processing | IMP |
| GO:0006457 | protein folding | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IEA |
| GO:0005730 | nucleolus | IDA |
| GO:0005730 | nucleolus | IEA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005739 | mitochondrion | IEA |
| GO:0005759 | mitochondrial matrix | IDA |
| GO:0005759 | mitochondrial matrix | IEA |
| GO:0005819 | spindle | IDA |
| GO:0005819 | spindle | IEA |
| GO:0005856 | cytoskeleton | IEA |
| GO:0030684 | preribosome | IDA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GO:0003681 | bent DNA binding | IDA |
| GO:0003690 | double-stranded DNA binding | IDA |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA |
| GO:0016853 | isomerase activity | IEA |
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