• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PITX2 paired-like homeodomain 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17360 NM_000325 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17480 NM_001204399 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 6, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17508 NM_153426 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu17508 NM_001204398 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu17508 NM_001204397 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu17480 NM_153427 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17508 XM_006714235 PREDICTED: Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu17360C NM_000325 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu17480C NM_001204399 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 6, mRNA. Customized vector In-stock 5-7 $149.00
OHu17508C NM_153426 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu17508C NM_001204398 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 5, mRNA. Customized vector On-demand 7-9 $209.00
OHu17508C NM_001204397 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu17480C NM_153427 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu17508C XM_006714235 PREDICTED: Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol PITX2
Entrez Gene ID 5308
Full Name paired-like homeodomain 2
Synonyms ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q25

Summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601542

Axenfeld-Rieger syndrome, type 1, 180500 (3); Iridogoniodysgenesis,

mRNA Protein Product Sequence Price Select
NM_000325, 152963645 NP_000316, 21361183 pituitary homeobox 2 isoform c ORF Sequence $269.00
NM_001204397, 324710991 NP_001191326, 324710992 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_001204398, 324710993 NP_001191327, 324710994 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_001204399, 324710995 NP_001191328, 324710996 pituitary homeobox 2 isoform a ORF Sequence $199.00
NM_153426, 324711005 NP_700475, 24234708 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_153427, 324711006 NP_700476, 24234711 pituitary homeobox 2 isoform a ORF Sequence $199.00
XM_006714235, 578809166 XP_006714298, 578809167 pituitary homeobox 2 isoform X1 ORF Sequence $400.00
KEGG
hsa04350TGF-beta signaling pathway
WikiPathways
WP1591Heart Development
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Homo sapiens (human)PITX2NP_000316.2
Pan troglodytes (chimpanzee)PITX2XP_001141234.1
Macaca mulatta (Rhesus monkey)PITX2XP_001091288.1
Canis lupus familiaris (dog)PITX2XP_851370.1
Bos taurus (cattle)PITX2NP_001091460.1
Mus musculus (house mouse)Pitx2NP_001035967.1
Rattus norvegicus (Norway rat)Pitx2NP_001035970.1
Gallus gallus (chicken)PITX2NP_990341.1
Danio rerio (zebrafish)pitx2NP_571050.1
Drosophila melanogaster (fruit fly)Ptx1NP_733410.2
Xenopus (Silurana) tropicalis (western clawed frog)pitx2NP_001017227.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001569patterning of blood vesselsIEA
GO:0001570vasculogenesisIEA
GO:0001701in utero embryonic developmentIEA
GO:0001764neuron migrationIEA
GO:0002074extraocular skeletal muscle developmentIEA
GO:0003171atrioventricular valve developmentIEA
GO:0003253cardiac neural crest cell migration involved in outflow tract morphogenesisISS
GO:0003350pulmonary myocardium developmentIEA
GO:0006355regulation of transcription, DNA-templatedIDA
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0007368determination of left/right symmetryISS
GO:0007520myoblast fusionIEA
GO:0008584male gonad developmentIEA
GO:0008585female gonad developmentIEA
GO:0009725response to hormoneIEA
GO:0016055Wnt signaling pathwayIEA
GO:0021763subthalamic nucleus developmentIEA
GO:0021855hypothalamus cell migrationIEA
GO:0030334regulation of cell migrationIEA
GO:0031076embryonic camera-type eye developmentIEA
GO:0033189response to vitamin AIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035315hair cell differentiationIC
GO:0035886vascular smooth muscle cell differentiationIEA
GO:0035993deltoid tuberosity developmentIMP
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0042476odontogenesisIMP
GO:0043010camera-type eye developmentIMP
GO:0043388positive regulation of DNA bindingIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048536spleen developmentISS
GO:0048557embryonic digestive tract morphogenesisIEA
GO:0055009atrial cardiac muscle tissue morphogenesisIEA
GO:0055015ventricular cardiac muscle cell developmentIEA
GO:0060126somatotropin secreting cell differentiationTAS
GO:0060127prolactin secreting cell differentiationTAS
GO:0060412ventricular septum morphogenesisIEA
GO:0060460left lung morphogenesisIEA
GO:0060577pulmonary vein morphogenesisIEA
GO:0060578superior vena cava morphogenesisIEA
GO:0061031endodermal digestive tract morphogenesisIEA
GO:0061072iris morphogenesisIMP
GO:0061325cell proliferation involved in outflow tract morphogenesisISS
GO:0070986left/right axis specificationISS
GO:2000288positive regulation of myoblast proliferationIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005667transcription factor complexIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0000976transcription regulatory region sequence-specific DNA bindingIDA
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDA
GO:0001085RNA polymerase II transcription factor bindingIPI
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0001105RNA polymerase II transcription coactivator activityIDA
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0031490chromatin DNA bindingIEA
GO:0042803protein homodimerization activityIPI
GO:0043021ribonucleoprotein complex bindingIC
GO:0051219phosphoprotein bindingIPI
GeneCards PITX2
UniProt Q99697
Vega OTTHUMG00000132837
MIM 601542
Ensembl ENSG00000164093
HGNC 9005
HPRD 03328

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.