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PITX2 paired-like homeodomain 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000325 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001204397 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001204398 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001204399 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 6, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_153426 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_153427 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

*Business Day

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Gene Symbol PITX2
Entrez Gene ID 5308
Full Name paired-like homeodomain 2
Synonyms ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q25

Summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601542

Axenfeld-Rieger syndrome, type 1, 180500 (3); Iridogoniodysgenesis,

mRNA Protein Product Sequence Price Select
NM_000325, 152963645 NP_000316, 21361183 pituitary homeobox 2 isoform c ORF Sequence $269.00
NM_001204397, 324710991 NP_001191326, 324710992 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_001204398, 324710993 NP_001191327, 324710994 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_001204399, 324710995 NP_001191328, 324710996 pituitary homeobox 2 isoform a ORF Sequence $199.00
NM_153426, 324711005 NP_700475, 24234708 pituitary homeobox 2 isoform b ORF Sequence $400.00
NM_153427, 324711006 NP_700476, 24234711 pituitary homeobox 2 isoform a ORF Sequence $199.00
KEGG
hsa04350TGF-beta signaling pathway
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
WikiPathways
WP1591Heart Development
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
Homo sapiens (human)PITX2NP_000316.2
Pan troglodytes (chimpanzee)PITX2XP_001141234.1
Macaca mulatta (Rhesus monkey)PITX2XP_001091288.1
Canis lupus familiaris (dog)PITX2XP_851370.1
Bos taurus (cattle)PITX2NP_001091460.1
Mus musculus (house mouse)Pitx2NP_001035967.1
Rattus norvegicus (Norway rat)Pitx2NP_001035970.1
Gallus gallus (chicken)PITX2NP_990341.1
Danio rerio (zebrafish)pitx2NP_571050.1
Drosophila melanogaster (fruit fly)Ptx1NP_001138130.1
Caenorhabditis elegansunc-30NP_001021276.1
GeneCards PITX2
PDB 2L7F, 2LKX, 2L7M
UniProt Q99697
MIM 601542
Ensembl ENSG00000164093
HGNC 9005
HPRD 03328

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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