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PLAGL1 pleiomorphic adenoma gene-like 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001080951 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001080952 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001080953 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001080954 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001080955 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001080956 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289037 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289038 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289039 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 13, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289040 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 14, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289041 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 21, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289042 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289043 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289044 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 15, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289045 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 16, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289046 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 17, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289047 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 18, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289048 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 19, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001289049 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 20, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_002656 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_006718 Homo sapiens pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol PLAGL1
Entrez Gene ID 5325
Full Name pleiomorphic adenoma gene-like 1
Synonyms LOT1, ZAC, ZAC1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q24-q25

Summary This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010].
Disorder

MIM: 603044

{Diabetes mellitus, transient neonatal}, 601410 (1)

mRNA Protein Product Sequence Price Select
NM_001080951, 124381124 NP_001074420, 124381125 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001080952, 124381126 NP_001074421, 124381127 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001080953, 124381128 NP_001074422, 124381129 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001080954, 124381130 NP_001074423, 124381131 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001080955, 124381132 NP_001074424, 124381133 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001080956, 124381134 NP_001074425, 124381135 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289037, 573459731 NP_001275966, 573459732 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289038, 573459764 NP_001275967, 573459765 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289039, 573459767 NP_001275968, 573459768 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289040, 573459716 NP_001275969, 573459717 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289041, 573459691 NP_001275970, 573459692 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_001289042, 573459689 NP_001275971, 573459690 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289043, 573459740 NP_001275972, 573459741 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289044, 573459687 NP_001275973, 573459688 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289045, 573459742 NP_001275974, 573459743 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289046, 573459733 NP_001275975, 573459734 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289047, 573459702 NP_001275976, 573459703 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289048, 573459735 NP_001275977, 573459736 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_001289049, 573459753 NP_001275978, 573459754 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
NM_002656, 124381123 NP_002647, 37622890 zinc finger protein PLAGL1 isoform 1 ORF Sequence $400.00
NM_006718, 124381122 NP_006709, 27894293 zinc finger protein PLAGL1 isoform 2 ORF Sequence $550.00
Homo sapiens (human)PLAGL1NP_001074423.1
Pan troglodytes (chimpanzee)PLAGL1XP_001172636.1
Macaca mulatta (Rhesus monkey)PLAGL1XP_001088396.1
Canis lupus familiaris (dog)PLAGL1XP_541135.1
Bos taurus (cattle)PLAGL1NP_001096759.1
Mus musculus (house mouse)Plagl1NP_033564.2
Rattus norvegicus (Norway rat)Plagl1NP_036892.1
Gallus gallus (chicken)LOC769676XP_001232448.2
Process
IDNameEvidence
GO:0006366transcription from RNA polymerase II promoterIBA
GO:0006915apoptotic processIEA
GO:0007050cell cycle arrestTAS
GO:0030154cell differentiationIBA
GO:0035914skeletal muscle cell differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
Component
IDNameEvidence
GO:0005634nucleusIBA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIDA
Function
IDNameEvidence
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityIBA
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0003677DNA bindingIDA
GO:0046872metal ion bindingIEA
GeneCards PLAGL1
UniProt A1YLA1, Q9UM63, A1YLA2
Vega OTTHUMG00000015738
MIM 603044
Ensembl ENSG00000118495
HGNC 9046
HPRD 16010

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PLAGL1 gene?

The PLAGL1 gene provides instructions for making a member of a protein family called zinc finger proteins. Zinc finger proteins are involved in many cellular functions. These proteins each contain one or more short regions called zinc finger domains, which include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions).

Zinc finger proteins attach (bind) primarily to DNA. In most cases, they attach to regions near certain genes and turn the genes on and off as needed. Proteins that bind to DNA and regulate the activity of particular genes are known as transcription factors. Some zinc finger proteins can also bind to other molecules, including RNA (a chemical cousin of DNA) and proteins.

The PLAGL1 protein helps regulate the cell's process for replicating itself in an organized, step-by-step fashion (cell cycle), and is involved in the self-destruction of cells (apoptosis). It is also important in fetal growth. The PLAGL1 protein helps control another protein called the pituitary adenylate cyclase-activating polypeptide receptor (PACAP1). One of the functions of the PACAP1 protein is to stimulate insulin secretion by beta cells in the pancreas. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy.

PLAGL1 is a paternally expressed imprinted gene, which means that normally only the copy of the gene that comes from the father is active. The copy of the gene that comes from the mother is inactivated (silenced) by a mechanism called methylation.

Interactant

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