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PLCB4 phospholipase C, beta 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000933 Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001172646 Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_182797 Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005260724 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005260728 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006723568 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006723569 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006723570 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006723571 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006723572 PREDICTED: Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol PLCB4
Entrez Gene ID 5332
Full Name phospholipase C, beta 4
Synonyms ARCND2, PI-PLC
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20p12

Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].
Disorder

MIM: 600810

mRNA Protein Product Sequence Price Select
NM_000933, 289547588 NP_000924, 289547589 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a ORF Sequence $1500.00
NM_001172646, 289547593 NP_001166117, 289547594 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c ORF Sequence $1500.00
NM_182797, 289547590 NP_877949, 289547591 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b ORF Sequence $1500.00
XM_005260724, 530425738 XP_005260781, 530425739 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 ORF Sequence $1500.00
XM_005260728, 530425746 XP_005260785, 530425747 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7 ORF Sequence $750.00
XM_006723568, 578835416 XP_006723631, 578835417 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8 ORF Sequence $1500.00
XM_006723569, 578835418 XP_006723632, 578835419 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X9 ORF Sequence $1500.00
XM_006723570, 578835420 XP_006723633, 578835421 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X10 ORF Sequence $1500.00
XM_006723571, 578835422 XP_006723634, 578835423 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X11 ORF Sequence $1500.00
XM_006723572, 578835424 XP_006723635, 578835425 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X12 ORF Sequence $1500.00
KEGG
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04916Melanogenesis
hsa04912GnRH signaling pathway
hsa05016Huntington's disease
hsa04540Gap junction
hsa05010Alzheimer's disease
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05142Chagas disease (American trypanosomiasis)
hsa05146Amoebiasis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05143African trypanosomiasis
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa_M00130Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04919Thyroid hormone signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP2059Alzheimers Disease
Reactome
REACT_19184GPCR downstream signaling
REACT_18283G alpha (q) signalling events
REACT_14797Signaling by GPCR
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_15426PLC beta mediated events
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_150154Inositol phosphate metabolism
REACT_150312Synthesis of IP3 and IP4 in the cytosol
Homo sapiens (human)PLCB4NP_877949.2
Pan troglodytes (chimpanzee)PLCB4XP_001168348.2
Macaca mulatta (Rhesus monkey)PLCB4XP_002798260.1
Canis lupus familiaris (dog)PLCB4XP_859719.2
Bos taurus (cattle)PLCB4NP_001159982.1
Mus musculus (house mouse)Plcb4NP_038857.1
Rattus norvegicus (Norway rat)Plcb4NP_077329.1
Gallus gallus (chicken)PLCB4NP_001186364.1
Danio rerio (zebrafish)LOC100537538XP_003200348.2
Drosophila melanogaster (fruit fly)norpANP_001014720.1
Caenorhabditis elegansegl-8NP_001021346.1
Xenopus (Silurana) tropicalis (western clawed frog)plcb4XP_004914780.1
Process
IDNameEvidence
GO:0016042lipid catabolic processIEA
GO:0035556intracellular signal transductionIEA
GO:0043647inositol phosphate metabolic processTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005790smooth endoplasmic reticulumIEA
GO:0005829cytosolTAS
GO:0014069postsynaptic densityIEA
GO:0030425dendriteIEA
Function
IDNameEvidence
GO:0004435phosphatidylinositol phospholipase C activityIEA
GO:0004629phospholipase C activityTAS
GO:0004871signal transducer activityIEA
GO:0005509calcium ion bindingIEA
GeneCards PLCB4
UniProt Q15147
Vega OTTHUMG00000031853
MIM 600810
Ensembl ENSG00000101333
HGNC 9059
HPRD 02885

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PLCB4 gene?

The PLCB4 gene provides instructions for making one form (the beta 4 isoform) of a protein called phospholipase C. This protein is involved in a signaling pathway within cells known as the phosphoinositide cycle, which helps transmit information from outside the cell to inside the cell. Phospholipase C carries out one particular step in the phosphoinositide cycle: the conversion of a molecule called phosphatidylinositol 4,5-bisphosphate (PIP2) to two smaller molecules, inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol. These smaller molecules relay messages into the cell that ultimately influence many cell activities.

Studies suggest that the beta 4 isoform of phospholipase C contributes to the development of the first and second pharyngeal arches. These embryonic structures ultimately develop into the jawbones, facial muscles, middle ear bones, ear canals, outer ears, and related tissues. This protein is also thought to play a role in vision, particularly in the function of the retina, which is a specialized tissue at the back of the eye that detects light and color.

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