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PLG plasminogen [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000301 Homo sapiens plasminogen (PLG), transcript variant 1, mRNA. ORF Sequence $705.57
Peptide Services
Antibody Services
Protein Services
NM_001168338 Homo sapiens plasminogen (PLG), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol PLG
Entrez Gene ID 5340
Full Name plasminogen
Synonyms DKFZp779M0222
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q26

Summary The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
Disorder

MIM: 173350

Plasminogen Tochigi disease (3); Thrombophilia, dysplasminogenemic

mRNA Protein Product Sequence Price Select
NM_000301, 270132869 NP_000292, 4505881 plasminogen isoform 1 precursor Full Length $1238.30
ORF Sequence $705.57
NM_001168338, 270132875 NP_001161810, 270132876 plasminogen isoform 2 precursor Full Length $348.00
ORF Sequence $159.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa05150Staphylococcus aureus infection
hsa05164Influenza A
hsa04610Complement and coagulation cascades
WikiPathways
WP558Complement and Coagulation Cascades
WP272Blood Clotting Cascade
WP15Selenium Pathway
Pathway Interaction Database
amb2_neutrophils_pathwayamb2 Integrin signaling
p75ntrpathwayp75(NTR)-mediated signaling
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
syndecan_4_pathwaySyndecan-4-mediated signaling events
Reactome
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_798Platelet activation, signaling and aggregation
REACT_15428Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_116125Disease
REACT_111102Signal Transduction
REACT_118779Extracellular matrix organization
REACT_318Platelet degranulation
REACT_118572Degradation of the extracellular matrix
REACT_16888Signaling by PDGF
REACT_118682Activation of Matrix Metalloproteinases
REACT_641Dissolution of Fibrin Clot
REACT_15380Diabetes pathways
REACT_604Hemostasis
Homo sapiens (human)PLGNP_000292.1
Pan troglodytes (chimpanzee)PLGXP_001152889.1
Macaca mulatta (Rhesus monkey)PLGNP_001036540.1
Canis lupus familiaris (dog)PLGXP_533468.2
Bos taurus (cattle)PLGNP_776376.1
Mus musculus (house mouse)PlgNP_032903.3
Rattus norvegicus (Norway rat)PlgNP_445943.1
Gallus gallus (chicken)PLGXP_419618.2
Danio rerio (zebrafish)plgNP_958880.1
GeneCards PLG
PDB 1KRN, 1HPK, 2DOH, 4A5T, 1HPJ, 1CEB, 1BUI, 3UIR, 1PK4, 1B2I, 1CEA, 5HPG, 2L0S, 4DCB, 1I5K, 2KNF, 4DUU, 1KI0, 1L4D, 4DUR, 1PMK, 1QRZ, 1RJX, 1DDJ, 1PKR, 2PK4, 2DOI, 1BML, 1L4Z
UniProt P00747, Q5TEH5
MIM 173350
Ensembl ENSG00000122194
HGNC 9071
HPRD 01417

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant

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