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PLG plasminogen [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	PLG
Entrez Gene ID	5340
Full Name	plasminogen
Synonyms	DKFZp779M0222
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:6 Map Location:6q26
Summary	The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
Disorder	MIM: 173350 Plasminogen Tochigi disease (3); Thrombophilia, dysplasminogenemic

mRNA	NM_000301, 270132869
Protein	NP_000292, 4505881
Product	plasminogen isoform 1 precursor
RefSeq Status	REVIEWED
mRNA	NM_001168338, 270132875
Protein	NP_001161810, 270132876
Product	plasminogen isoform 2 precursor
RefSeq Status	REVIEWED

KEGG

hsa05150	Staphylococcus aureus infection
hsa04610	Complement and coagulation cascades
hsa04080	Neuroactive ligand-receptor interaction

Pathway Interaction Database

p75ntrpathway	p75(NTR)-mediated signaling
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
syndecan_4_pathway	Syndecan-4-mediated signaling events
amb2_neutrophils_pathway	amb2 Integrin signaling

WikiPathways

WP272	Blood Clotting Cascade
WP558	Complement and Coagulation Cascades
WP15	Selenium Pathway

Reactome

REACT_15428	Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_318	Platelet degranulation
REACT_16888	Signaling by PDGF
REACT_641	Dissolution of Fibrin Clot
REACT_15380	Diabetes pathways
REACT_604	Hemostasis
REACT_1280	Response to elevated platelet cytosolic Ca2+
REACT_798	Platelet Activation
REACT_20	Formation of Platelet plug

Homo sapiens (human)	PLG	NP_000292.1
Pan troglodytes (chimpanzee)	PLG	XP_001152830.1
Canis lupus familiaris (dog)	PLG	XP_533468.2
Bos taurus (cattle)	PLG	NP_776376.1
Mus musculus (house mouse)	Plg	NP_032903.2
Rattus norvegicus (Norway rat)	Plg	XP_574314.1
Gallus gallus (chicken)	PLG	XP_419618.2
Danio rerio (zebrafish)	plg	NP_958880.1

Process

ID	Name	Evidence
GO:0002576	platelet degranulation	TAS
GO:0006508	proteolysis	IEA
GO:0007596	blood coagulation	IMP
GO:0007596	blood coagulation	TAS
GO:0008285	negative regulation of cell proliferation	TAS
GO:0010812	negative regulation of cell-substrate adhesion	IDA
GO:0022617	extracellular matrix disassembly	IDA
GO:0030168	platelet activation	TAS
GO:0042730	fibrinolysis	TAS
GO:0048771	tissue remodeling	IEA
GO:0051918	negative regulation of fibrinolysis	IDA
GO:0051919	positive regulation of fibrinolysis	IDA

Component

ID	Name	Evidence
GO:0005576	extracellular region	EXP
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005886	plasma membrane	TAS
GO:0031093	platelet alpha granule lumen	TAS
GO:0031232	extrinsic to external side of plasma membrane	IDA

Function

ID	Name	Evidence
GO:0004252	serine-type endopeptidase activity	EXP
GO:0004252	serine-type endopeptidase activity	IDA
GO:0004252	serine-type endopeptidase activity	TAS
GO:0005515	protein binding	IPI
GO:0008233	peptidase activity	IEA
GO:0034185	apolipoprotein binding	IPI
GO:0043498	cell surface binding	IDA

GeneCards	PLG
PDB	1KRN, 1HPK, 2DOH, 1HPJ, 1CEB, 1BUI, 1PK4, 1B2I, 1CEA, 5HPG, 2L0S, 1I5K, 2KNF, 1KI0, 1L4D, 1PMK, 1QRZ, 1RJX, 1DDJ, 1PKR, 2PK4, 2DOI, 1BML, 1L4Z
UniProt	P00747, Q5TEH5
MIM	173350
Ensembl	ENSG00000122194
HGNC	9071
HPRD	01417

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