• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PLG plasminogen [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22248 NM_001168338 Homo sapiens plasminogen (PLG), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu22912 NM_000301 Homo sapiens plasminogen (PLG), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22248C NM_001168338 Homo sapiens plasminogen (PLG), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu22912C NM_000301 Homo sapiens plasminogen (PLG), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00

*Business Day

Related Services

Gene Symbol PLG
Entrez Gene ID 5340
Full Name plasminogen
Synonyms
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q26

Summary The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
Disorder

MIM: 173350

Plasminogen Tochigi disease (3); Thrombophilia, dysplasminogenemic

mRNA Protein Product Sequence Price Select
NM_000301, 270132869 NP_000292, 4505881 plasminogen isoform 1 precursor ORF Sequence $750.00
NM_001168338, 270132875 NP_001161810, 270132876 plasminogen isoform 2 precursor ORF Sequence $150.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
hsa05164Influenza A
WikiPathways
WP15Selenium Pathway
WP272Blood Clotting Cascade
Pathway Interaction Database
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
amb2_neutrophils_pathwayamb2 Integrin signaling
syndecan_4_pathwaySyndecan-4-mediated signaling events
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_641Dissolution of Fibrin Clot
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_17015Metabolism of proteins
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_118682Activation of Matrix Metalloproteinases
Homo sapiens (human)PLGNP_000292.1
Pan troglodytes (chimpanzee)PLGXP_001152889.1
Macaca mulatta (Rhesus monkey)PLGNP_001036540.1
Canis lupus familiaris (dog)PLGXP_005615617.1
Bos taurus (cattle)PLGNP_776376.1
Mus musculus (house mouse)PlgNP_032903.3
Rattus norvegicus (Norway rat)PlgNP_445943.1
Gallus gallus (chicken)PLGXP_419618.2
Danio rerio (zebrafish)plgNP_958880.1
Caenorhabditis eleganstry-1NP_494910.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496227XP_002938616.2
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007596blood coagulationIMP
GO:0007596blood coagulationTAS
GO:0008285negative regulation of cell proliferationTAS
GO:0010812negative regulation of cell-substrate adhesionIDA
GO:0022617extracellular matrix disassemblyIDA
GO:0022617extracellular matrix disassemblyTAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0042246tissue regenerationIEA
GO:0042730fibrinolysisTAS
GO:0044267cellular protein metabolic processTAS
GO:0045445myoblast differentiationIEA
GO:0046716muscle cell cellular homeostasisIEA
GO:0048771tissue remodelingIEA
GO:0051603proteolysis involved in cellular protein catabolic processIEA
GO:0051918negative regulation of fibrinolysisIDA
GO:0051919positive regulation of fibrinolysisIDA
GO:0060707trophoblast giant cell differentiationIEA
GO:0060716labyrinthine layer blood vessel developmentIEA
GO:0071674mononuclear cell migrationIEA
GO:2000048negative regulation of cell-cell adhesion mediated by cadherinTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIDA
GO:0031093platelet alpha granule lumenTAS
GO:0031232extrinsic component of external side of plasma membraneIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0004252serine-type endopeptidase activityIDA
GO:0005515protein bindingIPI
GO:0008236serine-type peptidase activityTAS
GO:0019904protein domain specific bindingIPI
GO:0034185apolipoprotein bindingIPI
GeneCards PLG
PDB 1KRN, 1HPK, 2DOH, 4A5T, 1HPJ, 1CEB, 1BUI, 3UIR, 1PK4, 1B2I, 1CEA, 5HPG, 2L0S, 4DCB, 1I5K, 2KNF, 4DUU, 1KI0, 1L4D, 4DUR, 1PMK, 1QRZ, 1RJX, 1DDJ, 1PKR, 2PK4, 2DOI, 1BML, 1L4Z
UniProt P00747, Q5TEH5
Vega OTTHUMG00000015957
MIM 173350
Ensembl ENSG00000122194
HGNC 9071
HPRD 01417

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.