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PLN phospholamban [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17925 NM_002667 Homo sapiens phospholamban (PLN), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17925C NM_002667 Homo sapiens phospholamban (PLN), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PLN
Entrez Gene ID 5350
Full Name phospholamban
Synonyms CMD1P, CMH18, PLB
General protein information
Preferred Names
cardiac phospholamban
Names
cardiac phospholamban
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q22.1

Summary The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
Disorder

MIM: 172405

Cardiomyopathy, dilated, 1P, 609909 (3)

mRNA Protein Product Sequence Price Select
NM_002667, 194306634 NP_002658, 4505887 cardiac phospholamban ORF Sequence $99.00
KEGG
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP536Calcium Regulation in the Cardiac Cell
WP2377Integrated Pancreatic Cancer Pathway
Homo sapiens (human)PLNNP_002658.1
Pan troglodytes (chimpanzee)PLNXP_003311500.1
Process
IDNameEvidence
GO:0002026regulation of the force of heart contractionIC
GO:0006816calcium ion transportIEA
GO:0008015blood circulationNAS
GO:0008016regulation of heart contractionIMP
GO:0010043response to zinc ionIEA
GO:0010459negative regulation of heart rateIMP
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIEA
GO:0032780negative regulation of ATPase activityIDA
GO:0032780negative regulation of ATPase activityISS
GO:0033574response to testosteroneIEA
GO:0043086negative regulation of catalytic activityISS
GO:0048738cardiac muscle tissue developmentIEA
GO:0051260protein homooligomerizationIEA
GO:0051480cytosolic calcium ion homeostasisIC
GO:0051924regulation of calcium ion transportIDA
GO:0051924regulation of calcium ion transportISS
GO:0051926negative regulation of calcium ion transportIDA
GO:0055119relaxation of cardiac muscleTAS
GO:0060314regulation of ryanodine-sensitive calcium-release channel activityIEA
GO:0086004regulation of cardiac muscle cell contractionIC
GO:0086023adrenergic receptor signaling pathway involved in heart processIEA
GO:0086036regulation of cardiac muscle cell membrane potentialIC
GO:0086092regulation of the force of heart contraction by cardiac conductionIEA
GO:0090281negative regulation of calcium ion importISS
GO:1901020negative regulation of calcium ion transmembrane transporter activityIDA
GO:1901020negative regulation of calcium ion transmembrane transporter activityISS
GO:1901877negative regulation of calcium ion bindingIDA
GO:1901877negative regulation of calcium ion bindingISS
GO:1901894regulation of calcium-transporting ATPase activityIDA
GO:1901895negative regulation of calcium-transporting ATPase activityIDA
GO:1901897regulation of relaxation of cardiac muscleIC
GO:1902081negative regulation of calcium ion import into sarcoplasmic reticulumISS
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005783endoplasmic reticulumISS
GO:0016020membraneIDA
GO:0031966mitochondrial membraneIEA
GO:0031982vesicleIEA
GO:0033017sarcoplasmic reticulum membraneIEA
GO:0048471perinuclear region of cytoplasmISS
GO:0090534calcium ion-transporting ATPase complexIDA
Function
IDNameEvidence
GO:0004857enzyme inhibitor activityISS
GO:0005246calcium channel regulator activityIEA
GO:0005515protein bindingIPI
GO:0042030ATPase inhibitor activityIDA
GO:0042030ATPase inhibitor activityISS
GO:0042802identical protein bindingISS
GO:0051117ATPase bindingISS
GeneCards PLN
PDB 2HYN, 1PLN, 1PSL, 1PLP, 1KCH, 1ZLL, 1K9N
UniProt Q5R352, P26678
Vega OTTHUMG00000015462
MIM 172405
Ensembl ENSG00000198523
HGNC 9080
HPRD 01395

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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