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Sequence in raw or FASTA format:

Database:

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PLN phospholamban [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002667 Homo sapiens phospholamban (PLN), mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol PLN
Entrez Gene ID 5350
Full Name phospholamban
Synonyms CMD1P, PLB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q22.1

Summary The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
Disorder

MIM: 172405

Cardiomyopathy, dilated, 1P, 609909 (3)

mRNA Protein Product Sequence Price Select
NM_002667, 194306634 NP_002658, 4505887 cardiac phospholamban Full Length $505.18
ORF Sequence $159.00
KEGG
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
WikiPathways
WP536Calcium Regulation in the Cardiac Cell
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
Homo sapiens (human)PLNNP_002658.1
Pan troglodytes (chimpanzee)PLNXP_003311500.1
Macaca mulatta (Rhesus monkey)PLNXP_002803964.1
Canis lupus familiaris (dog)PLNNP_001003332.1
Bos taurus (cattle)PLNNP_001096789.1
Mus musculus (house mouse)PlnNP_001135399.1
Rattus norvegicus (Norway rat)PlnNP_073198.1
GeneCards PLN
PDB 2HYN, 1PLN, 1PSL, 1PLP, 1KCH, 1ZLL, 1K9N
UniProt Q5R352, P26678
MIM 172405
Ensembl ENSG00000198523
HGNC 9080
HPRD 01395

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cardiac phospholamban
Names
cardiac phospholamban

Interactant

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