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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PML promyelocytic leukemia [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002675 Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA. ORF Sequence $551.58
Peptide Services
Antibody Services
Protein Services
NM_033238 Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA. ORF Sequence $768.21
Peptide Services
Antibody Services
Protein Services
NM_033239 Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA. ORF Sequence $722.10
Peptide Services
Antibody Services
Protein Services
NM_033240 Homo sapiens promyelocytic leukemia (PML), transcript variant 2, mRNA. ORF Sequence $532.44
Peptide Services
Antibody Services
Protein Services
NM_033244 Homo sapiens promyelocytic leukemia (PML), transcript variant 5, mRNA. ORF Sequence $488.07
Peptide Services
Antibody Services
Protein Services
NM_033246 Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA. ORF Sequence $368.88
Peptide Services
Antibody Services
Protein Services
NM_033247 Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA. ORF Sequence $379.32
Peptide Services
Antibody Services
Protein Services
NM_033249 Homo sapiens promyelocytic leukemia (PML), transcript variant 10, mRNA. ORF Sequence $509.82
Peptide Services
Antibody Services
Protein Services
NM_033250 Homo sapiens promyelocytic leukemia (PML), transcript variant 11, mRNA. ORF Sequence $680.34
Peptide Services
Antibody Services
Protein Services


Gene Symbol PML
Entrez Gene ID 5371
Full Name promyelocytic leukemia
Synonyms MYL, PP8675, RNF71, TRIM19
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22

Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 102578

Leukemia, acute promyelocytic, PML/RARA type (3)

mRNA Protein Product Sequence Price Select
NM_002675, 67089152 NP_002666, 4505903 protein PML isoform 6 Full Length $653.66
ORF Sequence $551.58
NM_033238, 67089148 NP_150241, 67089149 protein PML isoform 1 Full Length $2520.00
ORF Sequence $768.21
NM_033239, 67089155 NP_150242, 15451765 protein PML isoform 9 Full Length $1080.80
ORF Sequence $722.10
NM_033240, 67089156 NP_150243, 67089157 protein PML isoform 2 Full Length $1312.85
ORF Sequence $532.44
NM_033244, 109637787 NP_150247, 109637788 protein PML isoform 5 Full Length $1083.60
ORF Sequence $488.07
NM_033246, 67089151 NP_150249, 15451775 protein PML isoform 7 Full Length $536.79
ORF Sequence $368.88
NM_033247, 67089153 NP_150250, 67089154 protein PML isoform 8 Full Length $521.13
ORF Sequence $379.32
NM_033249, 67089150 NP_150252, 15451779 protein PML isoform 10 Full Length $611.90
ORF Sequence $509.82
NM_033250, 67089159 NP_150253, 67089160 protein PML isoform 11 Full Length $853.76
ORF Sequence $680.34
KEGG
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05168Herpes simplex infection
hsa05202Transcriptional misregulation in cancer
hsa04144Endocytosis
hsa05164Influenza A
hsa04120Ubiquitin mediated proteolysis
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
WP1984Integrated Breast Cancer Pathway
WP707DNA damage response
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
mtor_4pathwaymTOR signaling pathway
tgfbrpathwayTGF-beta receptor signaling
p53downstreampathwayDirect p53 effectors
Reactome
REACT_25229Interferon Signaling
REACT_75790Cytokine Signaling in Immune system
REACT_25078Interferon gamma signaling
REACT_6900Immune System
Homo sapiens (human)PMLNP_150241.2
Pan troglodytes (chimpanzee)PMLNP_001035900.1
Macaca mulatta (Rhesus monkey)PMLNP_001035899.1
Canis lupus familiaris (dog)PMLXP_544766.3
Mus musculus (house mouse)PmlNP_835188.2
Rattus norvegicus (Norway rat)PmlXP_236296.4
Gallus gallus (chicken)PMLXP_413690.2
Gallus gallus (chicken)LOC100857563XP_003641860.1
GeneCards PML
PDB 1BOR
UniProt P29590
MIM 102578
Ensembl ENSG00000140464
HGNC 9113
HPRD 00023

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
protein PML
Names
protein PML
RING finger protein 71
promyelocytic leukemia protein
tripartite motif protein TRIM19
probable transcription factor PML
promyelocytic leukemia, inducer of
tripartite motif-containing protein 19

Interactant

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