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PML promyelocytic leukemia [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002675 Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_033238 Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_033239 Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_033240 Homo sapiens promyelocytic leukemia (PML), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_033244 Homo sapiens promyelocytic leukemia (PML), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_033246 Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_033247 Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_033249 Homo sapiens promyelocytic leukemia (PML), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_033250 Homo sapiens promyelocytic leukemia (PML), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol PML
Entrez Gene ID 5371
Full Name promyelocytic leukemia
Synonyms MYL, PP8675, RNF71, TRIM19
General protein information
Preferred Names
protein PML
Names
protein PML
RING finger protein 71
promyelocytic leukemia protein
tripartite motif protein TRIM19
probable transcription factor PML
promyelocytic leukemia, inducer of
tripartite motif-containing protein 19
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22

Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 102578

Leukemia, acute promyelocytic, PML/RARA type (3)

mRNA Protein Product Sequence Price Select
NM_002675, 67089152 NP_002666, 4505903 protein PML isoform 6 ORF Sequence $700.00
NM_033238, 67089148 NP_150241, 67089149 protein PML isoform 1 ORF Sequence $750.00
NM_033239, 67089155 NP_150242, 15451765 protein PML isoform 9 ORF Sequence $750.00
NM_033240, 67089156 NP_150243, 67089157 protein PML isoform 2 ORF Sequence $700.00
NM_033244, 109637787 NP_150247, 109637788 protein PML isoform 5 ORF Sequence $550.00
NM_033246, 67089151 NP_150249, 15451775 protein PML isoform 7 ORF Sequence $550.00
NM_033247, 67089153 NP_150250, 67089154 protein PML isoform 8 ORF Sequence $550.00
NM_033249, 67089150 NP_150252, 15451779 protein PML isoform 10 ORF Sequence $700.00
NM_033250, 67089159 NP_150253, 67089160 protein PML isoform 11 ORF Sequence $750.00
KEGG
hsa04120Ubiquitin mediated proteolysis
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP707DNA damage response
WP1984Integrated Breast Cancer Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
tgfbrpathwayTGF-beta receptor signaling
mtor_4pathwaymTOR signaling pathway
Reactome
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
Homo sapiens (human)PMLNP_150241.2
Pan troglodytes (chimpanzee)PMLNP_001035900.1
Macaca mulatta (Rhesus monkey)PMLNP_001035899.1
Canis lupus familiaris (dog)PMLXP_544766.4
Mus musculus (house mouse)PmlNP_835188.2
Rattus norvegicus (Norway rat)PmlXP_006243244.1
Gallus gallus (chicken)LOC100857563XP_004943755.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIDA
GO:0001932regulation of protein phosphorylationISS
GO:0002230positive regulation of defense response to virus by hostIMP
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIMP
GO:0006461protein complex assemblyIDA
GO:0006605protein targetingIDA
GO:0006605protein targetingIMP
GO:0006915apoptotic processIDA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestISS
GO:0007050cell cycle arrestIDA
GO:0007050cell cycle arrestIEA
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007182common-partner SMAD protein phosphorylationIEA
GO:0007184SMAD protein import into nucleusIEA
GO:0008285negative regulation of cell proliferationIMP
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIDA
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stressIEA
GO:0009411response to UVIEA
GO:0010332response to gamma radiationIEA
GO:0010522regulation of calcium ion transport into cytosolISS
GO:0016032viral processIEA
GO:0016525negative regulation of angiogenesisIMP
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0030099myeloid cell differentiationIEA
GO:0030308negative regulation of cell growthIDA
GO:0030578PML body organizationIDA
GO:0030578PML body organizationIMP
GO:0031065positive regulation of histone deacetylationIDA
GO:0032211negative regulation of telomere maintenance via telomeraseIMP
GO:0032469endoplasmic reticulum calcium ion homeostasisISS
GO:0032922circadian regulation of gene expressionISS
GO:0032938negative regulation of translation in response to oxidative stressIDA
GO:0034097response to cytokineIDA
GO:0042752regulation of circadian rhythmISS
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorISS
GO:0043153entrainment of circadian clock by photoperiodISS
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processIDA
GO:0045087innate immune responseIDA
GO:0045165cell fate commitmentIEA
GO:0045343regulation of MHC class I biosynthetic processIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045930negative regulation of mitotic cell cycleIDA
GO:0048384retinoic acid receptor signaling pathwayIEA
GO:0050821protein stabilizationIDA
GO:0051457maintenance of protein location in nucleusIDA
GO:0051607defense response to virusIEA
GO:0051974negative regulation of telomerase activityIMP
GO:0060058positive regulation of apoptotic process involved in mammary gland involutionIDA
GO:0060333interferon-gamma-mediated signaling pathwayTAS
GO:0060444branching involved in mammary gland duct morphogenesisIEA
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEA
GO:0071353cellular response to interleukin-4IEA
GO:0090398cellular senescenceIDA
GO:0097191extrinsic apoptotic signaling pathwayIEA
GO:1902187negative regulation of viral release from host cellIDA
GO:2000059negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIMP
GO:2000779regulation of double-strand break repairIMP
GO:2001238positive regulation of extrinsic apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolISS
GO:0016363nuclear matrixIDA
GO:0016363nuclear matrixIEA
GO:0016605PML bodyIDA
GO:0016605PML bodyIDA
GO:0016605PML bodyTAS
GO:0031901early endosome membraneIEA
GO:0031965nuclear membraneIDA
GO:0042406extrinsic component of endoplasmic reticulum membraneISS
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0003713transcription coactivator activityIDA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIDA
GO:0008270zinc ion bindingIEA
GO:0031625ubiquitin protein ligase bindingIPI
GO:0032183SUMO bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0046332SMAD bindingIEA
GO:0046982protein heterodimerization activityIDA
GO:0050897cobalt ion bindingIDA
GeneCards PML
UniProt P29590
Vega OTTHUMG00000137607
MIM 102578
Ensembl ENSG00000140464
HGNC 9113
HPRD 00023

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PML gene?

The PML gene provides instructions for a protein that acts as a tumor suppressor, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. The PML protein is found in distinct structures in the nucleus of a cell called PML nuclear bodies (PML-NBs). In the PML-NBs, the PML protein interacts with other proteins that are involved in cell growth and division (proliferation) and self-destruction (apoptosis). The PML protein is able to block cell proliferation and induce apoptosis in combination with other proteins. Researchers believe that the structure of the PML-NBs is required for blocking proliferation and inducing apoptosis.

Interactant

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