Sequence in raw or FASTA format:
FGFRL1 fibroblast growth factor receptor-like 1 [Homo sapiens (human)]
|Entrez Gene ID||53834|
|Full Name||fibroblast growth factor receptor-like 1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].|
|Homo sapiens (human)||FGFRL1||NP_068742.2|
|Macaca mulatta (Rhesus monkey)||FGFRL1||XP_001092871.1|
|Canis lupus familiaris (dog)||LOC102151155||XP_005618732.1|
|Bos taurus (cattle)||FGFRL1||NP_001192925.1|
|Mus musculus (house mouse)||Fgfrl1||NP_473412.1|
|Rattus norvegicus (Norway rat)||Fgfrl1||NP_954545.1|
|Gallus gallus (chicken)||FGFRL1||NP_989787.1|
|Danio rerio (zebrafish)||fgfrl1a||NP_956670.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||fgfrl1||NP_001011189.1|
|GO:0001501||skeletal system development||IEA|
|GO:0003179||heart valve morphogenesis||IEA|
|GO:0008285||negative regulation of cell proliferation||IEA|
|GO:0008543||fibroblast growth factor receptor signaling pathway||IDA|
|GO:0008543||fibroblast growth factor receptor signaling pathway||IEA|
|GO:0060412||ventricular septum morphogenesis||IEA|
|GO:0016021||integral component of membrane||IEA|
|GO:0005007||fibroblast growth factor-activated receptor activity||IDA|
|GO:0017134||fibroblast growth factor binding||IEA|
What is the normal function of the FGFRL1 gene?
The FGFRL1 gene produces a protein that is part of a family of fibroblast growth factor receptors that share similar structures and functions. This family of receptors plays a role in important processes such as cell division, cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Proteins in the FGFR family span the cell membrane, so that one end of the protein remains inside the cell (the intracellular portion) and the other end sits on the outer surface of the cell. This positioning of the protein allows it to receive signals from outside the cell that help the cell respond to its environment.
The FGFRL1 protein is considerably shorter than other members of the FGFR family as it lacks a segment of the intracellular portion. Although the role of this receptor protein remains unknown, its structure indicates that it could interact with other FGFR proteins and potentially inhibit cell signaling. FGFRL1 gene activity has been detected in fetal cartilage. This finding indicates that the FGFRL1 gene may be involved in skeletal formation during development.
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