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FGFRL1 fibroblast growth factor receptor-like 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001004356 Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001004358 Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_021923 Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol FGFRL1
Entrez Gene ID 53834
Full Name fibroblast growth factor receptor-like 1
Synonyms FGFR5, FHFR
General protein information
Preferred Names
fibroblast growth factor receptor-like 1
Names
fibroblast growth factor receptor-like 1
FGFR-5
FGFR-like protein
FGF receptor-like protein 1
FGF homologous factor receptor
fibroblast growth factor receptor 5
NP_001004356.1
NP_001004358.1
NP_068742.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605830

mRNA Protein Product Sequence Price Select
NM_001004356, 62388872 NP_001004356, 51988912 fibroblast growth factor receptor-like 1 precursor ORF Sequence $550.00
NM_001004358, 51988913 NP_001004358, 51988914 fibroblast growth factor receptor-like 1 precursor ORF Sequence $550.00
NM_021923, 51988909 NP_068742, 51988910 fibroblast growth factor receptor-like 1 precursor ORF Sequence $550.00
Homo sapiens (human)FGFRL1NP_068742.2
Macaca mulatta (Rhesus monkey)FGFRL1XP_001092871.1
Canis lupus familiaris (dog)LOC102151155XP_005618732.1
Bos taurus (cattle)FGFRL1NP_001192925.1
Mus musculus (house mouse)Fgfrl1NP_473412.1
Rattus norvegicus (Norway rat)Fgfrl1NP_954545.1
Gallus gallus (chicken)FGFRL1NP_989787.1
Danio rerio (zebrafish)fgfrl1aNP_956670.1
Caenorhabditis elegansigcm-4NP_508377.1
Xenopus (Silurana) tropicalis (western clawed frog)fgfrl1NP_001011189.1
Process
IDNameEvidence
GO:0001501skeletal system developmentIEA
GO:0003179heart valve morphogenesisIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0008543fibroblast growth factor receptor signaling pathwayIDA
GO:0008543fibroblast growth factor receptor signaling pathwayIEA
GO:0060412ventricular septum morphogenesisIEA
GO:0060539diaphragm developmentIEA
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0005007fibroblast growth factor-activated receptor activityIDA
GO:0008201heparin bindingIDA
GO:0017134fibroblast growth factor bindingIEA
GeneCards FGFRL1
UniProt A0PJ49, Q8N441
Vega OTTHUMG00000118998
MIM 605830
Ensembl ENSG00000127418
HGNC 3693
HPRD 16163

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FGFRL1 gene?

The FGFRL1 gene produces a protein that is part of a family of fibroblast growth factor receptors that share similar structures and functions. This family of receptors plays a role in important processes such as cell division, cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Proteins in the FGFR family span the cell membrane, so that one end of the protein remains inside the cell (the intracellular portion) and the other end sits on the outer surface of the cell. This positioning of the protein allows it to receive signals from outside the cell that help the cell respond to its environment.

The FGFRL1 protein is considerably shorter than other members of the FGFR family as it lacks a segment of the intracellular portion. Although the role of this receptor protein remains unknown, its structure indicates that it could interact with other FGFR proteins and potentially inhibit cell signaling. FGFRL1 gene activity has been detected in fetal cartilage. This finding indicates that the FGFRL1 gene may be involved in skeletal formation during development.

Interactant

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