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ATP7B ATPase, Cu++ transporting, beta polypeptide [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22580 NM_000053 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock TBD $1149.00
OHu22611 NM_001005918 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22960 NM_001243182 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu47202 XM_005266424 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47202 XM_005266423 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47202 XM_006719837 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X11, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47203 XM_005266427 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47204 XM_005266428 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47205 XM_005266429 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22580 XM_005266430 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X8, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47206 XM_005266432 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X10, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu47207 XM_006719838 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X12, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu47208 XM_006719839 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X13, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu47209 XM_005266431 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X9, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22580C NM_000053 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, mRNA. Customized vector In-stock TBD $1149.00
OHu22611C NM_001005918 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 2, mRNA. Customized vector On-demand TBD $1699.00
OHu22960C NM_001243182 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 3, mRNA. Customized vector On-demand 25 $1699.00
OHu47202C XM_005266424 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X2, mRNA. Customized vector On-demand TBD $1699.00
OHu47202C XM_005266423 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X1, mRNA. Customized vector On-demand TBD $1699.00
OHu47202C XM_006719837 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X11, mRNA. Customized vector On-demand TBD $1699.00
OHu47203C XM_005266427 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X5, mRNA. Customized vector On-demand TBD $1699.00
OHu47204C XM_005266428 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X6, mRNA. Customized vector On-demand TBD $1699.00
OHu47205C XM_005266429 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X7, mRNA. Customized vector On-demand TBD $1699.00
OHu22580C XM_005266430 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X8, mRNA. Customized vector On-demand TBD $1699.00
OHu47206C XM_005266432 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X10, mRNA. Customized vector On-demand TBD $1699.00
OHu47207C XM_006719838 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X12, mRNA. Customized vector On-demand 12-14 $329.00
OHu47208C XM_006719839 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X13, mRNA. Customized vector On-demand 12-14 $329.00
OHu47209C XM_005266431 PREDICTED: Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant X9, mRNA. Customized vector On-demand TBD $1699.00

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Gene Symbol ATP7B
Entrez Gene ID 540
Full Name ATPase, Cu++ transporting, beta polypeptide
Synonyms PWD, WC1, WD, WND
General protein information
Preferred Names
copper-transporting ATPase 2
Names
copper-transporting ATPase 2
copper pump 2
Wilson disease-associated protein
ATPase, Cu(2+)- transporting, beta polypeptide
NP_000044.2
NP_001005918.1
NP_001230111.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q14.3

Summary This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008].
Disorder

MIM: 606882

Wilson disease, 277900 (3)

mRNA Protein Product Sequence Price Select
NM_000053, 342187240 NP_000044, 55743071 copper-transporting ATPase 2 isoform a ORF Sequence $999.00
NM_001005918, 342187241 NP_001005918, 55743073 copper-transporting ATPase 2 isoform b ORF Sequence $1500.00
NM_001243182, 342187273 NP_001230111, 342187274 copper-transporting ATPase 2 isoform c ORF Sequence $1500.00
XM_005266423, 530402435 XP_005266480, 530402436 copper-transporting ATPase 2 isoform X1 ORF Sequence $1500.00
XM_005266424, 578824918 XP_005266481, 530402438 copper-transporting ATPase 2 isoform X2 ORF Sequence $1500.00
XM_005266427, 578824922 XP_005266484, 530402444 copper-transporting ATPase 2 isoform X5 ORF Sequence $1500.00
XM_005266428, 530402445 XP_005266485, 530402446 copper-transporting ATPase 2 isoform X6 ORF Sequence $1500.00
XM_005266429, 578824923 XP_005266486, 530402448 copper-transporting ATPase 2 isoform X7 ORF Sequence $1500.00
XM_005266430, 578824924 XP_005266487, 530402450 copper-transporting ATPase 2 isoform X8 ORF Sequence $1500.00
XM_005266431, 530402451 XP_005266488, 530402452 copper-transporting ATPase 2 isoform X9 ORF Sequence $1500.00
XM_005266432, 578824925 XP_005266489, 530402454 copper-transporting ATPase 2 isoform X10 ORF Sequence $1500.00
XM_006719837, 578824919 XP_006719900, 578824920 copper-transporting ATPase 2 isoform X11 ORF Sequence $1500.00
XM_006719838, 578824926 XP_006719901, 578824927 copper-transporting ATPase 2 isoform X12 ORF Sequence $700.00
XM_006719839, 578824928 XP_006719902, 578824929 copper-transporting ATPase 2 isoform X13 ORF Sequence $700.00
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
Homo sapiens (human)ATP7BNP_000044.2
Pan troglodytes (chimpanzee)LOC452734XP_003314205.1
Macaca mulatta (Rhesus monkey)ATP7BXP_001103242.2
Canis lupus familiaris (dog)ATP7BNP_001020438.1
Bos taurus (cattle)ATP7BXP_002691840.1
Mus musculus (house mouse)Atp7bNP_031537.2
Rattus norvegicus (Norway rat)Atp7bNP_036643.2
Gallus gallus (chicken)ATP7BXP_417073.3
Danio rerio (zebrafish)atp7bXP_684415.5
Arabidopsis thaliana (thale cress)RAN1NP_199292.1
Xenopus (Silurana) tropicalis (western clawed frog)atp7bXP_002936778.2
Process
IDNameEvidence
GO:0006825copper ion transportIGI
GO:0006878cellular copper ion homeostasisTAS
GO:0006882cellular zinc ion homeostasisIEA
GO:0007595lactationIEA
GO:0008152metabolic processIEA
GO:0015677copper ion importIDA
GO:0015680intracellular copper ion transportIEA
GO:0034220ion transmembrane transportTAS
GO:0046688response to copper ionIDA
GO:0051208sequestering of calcium ionIDA
GO:0055085transmembrane transportTAS
GO:0060003copper ion exportIEA
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005739mitochondrionIEA
GO:0005770late endosomeIDA
GO:0005802trans-Golgi networkIDA
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneIDA
GO:0016023cytoplasmic membrane-bounded vesicleIDA
GO:0016323basolateral plasma membraneIDA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0004008copper-exporting ATPase activityNAS
GO:0004008copper-exporting ATPase activityTAS
GO:0005507copper ion bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GeneCards ATP7B
UniProt E7EQQ2, B7ZLR4, P35670, E7ET55
Vega OTTHUMG00000017406
MIM 606882
Ensembl ENSG00000123191
HGNC 870
HPRD 06050

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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