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ATP7B ATPase, Cu++ transporting, beta polypeptide [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000053 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 TBD
NM_001005918 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001243182 Homo sapiens ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol ATP7B
Entrez Gene ID 540
Full Name ATPase, Cu++ transporting, beta polypeptide
Synonyms PWD, WC1, WD, WND
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008].

MIM: 606882

Wilson disease, 277900 (3)

mRNA Protein Product Sequence Price Select
NM_000053, 342187240 NP_000044, 55743071 copper-transporting ATPase 2 isoform a ORF Sequence $999.00
NM_001005918, 342187241 NP_001005918, 55743073 copper-transporting ATPase 2 isoform b ORF Sequence $1500.00
NM_001243182, 342187273 NP_001230111, 342187274 copper-transporting ATPase 2 isoform c ORF Sequence $1500.00
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)ATP7BNP_000044.2
Pan troglodytes (chimpanzee)LOC452734XP_003314205.1
Macaca mulatta (Rhesus monkey)ATP7BXP_001103242.2
Canis lupus familiaris (dog)ATP7BNP_001020438.1
Bos taurus (cattle)ATP7BXP_002691840.1
Mus musculus (house mouse)Atp7bNP_031537.2
Rattus norvegicus (Norway rat)Atp7bNP_036643.2
Gallus gallus (chicken)ATP7BXP_417073.3
Danio rerio (zebrafish)atp7bXP_684415.4
Drosophila melanogaster (fruit fly)ATP7NP_572756.3
Arabidopsis thaliana (thale cress)RAN1NP_199292.1
GeneCards ATP7B
UniProt B7ZLR4, P35670
MIM 606882
Ensembl ENSG00000123191
HGNC 870
HPRD 06050

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
copper-transporting ATPase 2
copper-transporting ATPase 2
copper pump 2
Wilson disease-associated protein
ATPase, Cu(2+)- transporting, beta polypeptide


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