POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) [Homo sapiens (human)]
| Gene Symbol | POLE3 |
| Entrez Gene ID | 54107 |
| Full Name | polymerase (DNA directed), epsilon 3 (p17 subunit) |
| Synonyms | CHARAC17, CHRAC17, YBL1, p17 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9q33 |
| Summary | POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 607267 |
| mRNA | NM_017443, 224586803 |
| Protein | NP_059139, 224586804 |
| Product | DNA polymerase epsilon subunit 3 |
| RefSeq Status | VALIDATED |
| hsa00230 | Purine metabolism |
| hsa03420 | Nucleotide excision repair |
| hsa03030 | DNA replication |
| hsa03410 | Base excision repair |
| hsa00240 | Pyrimidine metabolism |
| hsa01100 | Metabolic pathways |
| Homo sapiens (human) | POLE3 | NP_059139.3 |
| Pan troglodytes (chimpanzee) | POLE3 | XP_001153365.1 |
| Canis lupus familiaris (dog) | POLE3 | XP_855374.1 |
| Bos taurus (cattle) | POLE3 | NP_001029562.1 |
| Mus musculus (house mouse) | Pole3 | NP_067473.2 |
| Rattus norvegicus (Norway rat) | Pole3 | NP_001007653.1 |
| Gallus gallus (chicken) | POLE3 | NP_001020525.1 |
| Danio rerio (zebrafish) | pole3 | NP_957095.1 |
| Drosophila melanogaster (fruit fly) | Chrac-14 | NP_476647.2 |
| ID | Name | Evidence |
| GO:0006260 | DNA replication | TAS |
| GO:0043966 | histone H3 acetylation | IDA |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005634 | nucleus | IEA |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA |
Function
| ID | Name | Evidence |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0016740 | transferase activity | IEA |
| GO:0016779 | nucleotidyltransferase activity | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
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