• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


POLE polymerase (DNA directed), epsilon, catalytic subunit [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006231 Homo sapiens polymerase (DNA directed), epsilon, catalytic subunit (POLE), mRNA. GenEZ ORF Cloning On-demand $3749.00 35

*Business Day

Related Services

Gene Symbol POLE
Entrez Gene ID 5426
Full Name polymerase (DNA directed), epsilon, catalytic subunit
Synonyms CRCS12, FILS, POLE1
General protein information
Preferred Names
DNA polymerase epsilon catalytic subunit A
Names
DNA polymerase epsilon catalytic subunit A
DNA polymerase II subunit A
NP_006222.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.3

Summary This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013].
Disorder

MIM: 174762

mRNA Protein Product Sequence Price Select
NM_006231, 545746428 NP_006222, 62198237 DNA polymerase epsilon catalytic subunit A ORF Sequence $3500.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03030DNA replication
hsa03410Base excision repair
hsa03420Nucleotide excision repair
hsa05166HTLV-I infection
hsa_M00263DNA polymerase epsilon complex
WikiPathways
WP466DNA Replication
WP45G1 to S cell cycle control
WP2446RB in Cancer
Reactome
REACT_152Cell Cycle, Mitotic
REACT_1783G1/S Transition
REACT_1095Activation of the pre-replicative complex
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_1725M/G1 Transition
REACT_216DNA Repair
REACT_1826Nucleotide Excision Repair
REACT_2244DNA replication initiation
REACT_378Repair synthesis of patch ~27-30 bases long by DNA polymerase
REACT_1998Gap-filling DNA repair synthesis and ligation in GG-NER
REACT_1628Transcription-coupled NER (TC-NER)
REACT_74Gap-filling DNA repair synthesis and ligation in TC-NER
REACT_1993Repair synthesis for gap-filling by DNA polymerase in TC-NER
REACT_2253Global Genomic NER (GG-NER)
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_7993Telomere C-strand synthesis initiation
REACT_7970Telomere Maintenance
REACT_7961Telomere C-strand (Lagging Strand) Synthesis
REACT_8030Extension of Telomeres
REACT_21267Mitotic G1-G1/S phases
REACT_22172Chromosome Maintenance
REACT_115566Cell Cycle
Homo sapiens (human)POLENP_006222.2
Pan troglodytes (chimpanzee)POLEXP_522564.4
Canis lupus familiaris (dog)POLEXP_543348.3
Bos taurus (cattle)POLENP_001178358.1
Mus musculus (house mouse)PoleNP_035262.2
Rattus norvegicus (Norway rat)PoleNP_001100622.2
Gallus gallus (chicken)POLEXP_004934482.1
Danio rerio (zebrafish)poleNP_001121995.1
Drosophila melanogaster (fruit fly)DNApol-epsilonNP_524462.2
Caenorhabditis elegansF33H2.5NP_493616.1
Arabidopsis thaliana (thale cress)TIL2NP_180280.2
Arabidopsis thaliana (thale cress)TIL1NP_172303.5
Xenopus (Silurana) tropicalis (western clawed frog)poleXP_004910692.1
Process
IDNameEvidence
GO:0000082G1/S transition of mitotic cell cycleIMP
GO:0000082G1/S transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0000722telomere maintenance via recombinationTAS
GO:0000723telomere maintenanceTAS
GO:0000731DNA synthesis involved in DNA repairIMP
GO:0001701in utero embryonic developmentIEA
GO:0006260DNA replicationIMP
GO:0006270DNA replication initiationTAS
GO:0006281DNA repairTAS
GO:0006283transcription-coupled nucleotide-excision repairTAS
GO:0006287base-excision repair, gap-fillingIDA
GO:0006289nucleotide-excision repairTAS
GO:0006297nucleotide-excision repair, DNA gap fillingIMP
GO:0006297nucleotide-excision repair, DNA gap fillingTAS
GO:0032201telomere maintenance via semi-conservative replicationTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005886plasma membraneIDA
GO:0008622epsilon DNA polymerase complexIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003677DNA bindingIDA
GO:0003682chromatin bindingIDA
GO:0003887DNA-directed DNA polymerase activityIMP
GO:0008270zinc ion bindingIEA
GO:00515394 iron, 4 sulfur cluster bindingIEA
GeneCards POLE
UniProt Q07864
Vega OTTHUMG00000168045
MIM 174762
Ensembl ENSG00000177084
HGNC 9177
HPRD 07177

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.