Sequence in raw or FASTA format:

POLE polymerase (DNA directed), epsilon [Homo sapiens (human)]

Gene Symbol	POLE
Entrez Gene ID	5426
Full Name	polymerase (DNA directed), epsilon
Synonyms	DKFZp434F222, FLJ21434, POLE1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:12 Map Location:12q24.3
Summary
Disorder	MIM: 174762

mRNA	NM_006231, 62198236
Protein	NP_006222, 62198237
Product	DNA polymerase epsilon catalytic subunit A
RefSeq Status	VALIDATED

KEGG

WikiPathways

WP466	DNA Replication
WP45	G1 to S cell cycle control

Reactome

REACT_1993	Repair synthesis for gap-filling by DNA polymerase in TC-NER
REACT_2253	Global Genomic NER (GG-NER)
REACT_1725	M/G1 Transition
REACT_2014	Synthesis of DNA
REACT_152	Cell Cycle, Mitotic
REACT_7993	Telomere C-strand synthesis initiation
REACT_1095	Activation of the pre-replicative complex
REACT_74	Gap-filling DNA repair synthesis and ligation in TC-NER
REACT_1998	Gap-filling DNA repair synthesis and ligation in GG-NER
REACT_1783	G1/S Transition
REACT_383	DNA Replication
REACT_1826	Nucleotide Excision Repair
REACT_21300	Mitotic M-M/G1 phases
REACT_1628	Transcription-coupled NER (TC-NER)
REACT_22172	Chromosome Maintenance
REACT_21267	Mitotic G1-G1/S phases
REACT_378	Repair synthesis of patch ~27-30 bases long by DNA polymerase
REACT_899	S Phase
REACT_734	DNA Replication Pre-Initiation
REACT_8030	Extension of Telomeres
REACT_7961	Telomere C-strand (Lagging Strand) Synthesis
REACT_2244	DNA replication initiation
REACT_216	DNA Repair
REACT_7970	Telomere Maintenance

Homo sapiens (human)	POLE	NP_006222.2
Pan troglodytes (chimpanzee)	POLE	XP_522564.2
Canis lupus familiaris (dog)	POLE	XP_543348.2
Mus musculus (house mouse)	Pole	NP_035262.1
Rattus norvegicus (Norway rat)	Pole	XP_222255.3
Gallus gallus (chicken)	POLE	XP_001233985.1
Danio rerio (zebrafish)	pole	NP_001121995.1
Drosophila melanogaster (fruit fly)	DNApol-epsilon	NP_524462.2
Caenorhabditis elegans	F33H2.5	NP_493616.1
Arabidopsis thaliana (thale cress)	TIL2	NP_180280.2
Arabidopsis thaliana (thale cress)	TIL1	NP_001117247.1

Process

ID	Name	Evidence
GO:0000082	G1/S transition of mitotic cell cycle	IMP
GO:0000082	G1/S transition of mitotic cell cycle	TAS
GO:0000084	S phase of mitotic cell cycle	TAS
GO:0000216	M/G1 transition of mitotic cell cycle	TAS
GO:0000278	mitotic cell cycle	TAS
GO:0000722	telomere maintenance via recombination	TAS
GO:0000723	telomere maintenance	TAS
GO:0000731	DNA synthesis involved in DNA repair	IMP
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	IEA
GO:0006260	DNA replication	IMP
GO:0006270	DNA-dependent DNA replication initiation	TAS
GO:0006281	DNA repair	TAS
GO:0006283	transcription-coupled nucleotide-excision repair	TAS
GO:0006287	base-excision repair, gap-filling	IDA
GO:0006289	nucleotide-excision repair	TAS
GO:0006297	nucleotide-excision repair, DNA gap filling	EXP
GO:0006297	nucleotide-excision repair, DNA gap filling	IMP
GO:0032201	telomere maintenance via semi-conservative replication	TAS

Component

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0003677	DNA binding	IDA
GO:0003682	chromatin binding	IDA
GO:0003887	DNA-directed DNA polymerase activity	IMP
GO:0005515	protein binding	IPI
GO:0008270	zinc ion binding	IEA
GO:0016740	transferase activity	IEA
GO:0016779	nucleotidyltransferase activity	IEA
GO:0046872	metal ion binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_006231	Homo sapiens polymerase (DNA directed), epsilon (POLE), mRNA.	Full Length	$3536.55
NM_006231		ORF Sequence	$3087.45