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POLH polymerase (DNA directed), eta [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006502 Homo sapiens polymerase (DNA directed), eta (POLH), mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol POLH
Entrez Gene ID 5429
Full Name polymerase (DNA directed), eta
Synonyms FLJ16395, FLJ21978, RAD30, RAD30A, XP-V, XPV
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].

MIM: 603968

Xeroderma pigmentosum, variant type, 278750 (3)

mRNA Protein Product Sequence Price Select
NM_006502, 170650686 NP_006493, 5729982 DNA polymerase eta ORF Sequence $700.00
hsa03460Fanconi anemia pathway
REACT_216DNA Repair
REACT_2198Translesion synthesis by DNA polymerases bypassing lesion on DNA template
REACT_1287Translesion synthesis by Pol eta
REACT_2174DNA Damage Bypass
Homo sapiens (human)POLHNP_006493.1
Pan troglodytes (chimpanzee)POLHXP_518497.1
Macaca mulatta (Rhesus monkey)POLHXP_002803805.1
Canis lupus familiaris (dog)POLHXP_532150.2
Bos taurus (cattle)POLHNP_001029622.1
Mus musculus (house mouse)PolhNP_109640.1
Rattus norvegicus (Norway rat)PolhNP_001101674.1
Gallus gallus (chicken)POLHNP_001001304.1
Danio rerio (zebrafish)zgc:136881NP_001035337.1
Drosophila melanogaster (fruit fly)DNApol-etaNP_649371.2
Caenorhabditis eleganspolh-1NP_497480.2
Arabidopsis thaliana (thale cress)POLHNP_568638.2
GeneCards POLH
PDB 4DL3, 4ECQ, 2LSK, 4ECT, 2I5O, 4ECS, 3MR6, 4ED0, 4ECU, 4ED2, 3TQ1, 4EEY, 4DL7, 4ED8, 3MR2, 3MR5, 4ECR, 4ECV, 4DL2, 4ECY, 4ED6, 3SI8, 3MR3, 4ED7, 4ECX, 4ED1, 4ECZ, 4DL5, 4ECW, 4DL6, 4DL4, 4ED3
UniProt Q9Y253
MIM 603968
Ensembl ENSG00000170734
HGNC 9181
HPRD 04913

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
DNA polymerase eta
DNA polymerase eta
RAD30 homolog A
xeroderma pigmentosum variant type protein


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