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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


POLH polymerase (DNA directed), eta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24497 NM_006502 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu24571 NM_001291969 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu24572 NM_001291970 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu40354 XM_005249186 PREDICTED: Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu40355 XM_006715118 PREDICTED: Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu24497C NM_006502 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu24571C NM_001291969 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu24572C NM_001291970 Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu40354C XM_005249186 PREDICTED: Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu40355C XM_006715118 PREDICTED: Homo sapiens polymerase (DNA directed), eta (POLH), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol POLH
Entrez Gene ID 5429
Full Name polymerase (DNA directed), eta
Synonyms RAD30, RAD30A, XP-V, XPV
General protein information
Preferred Names
DNA polymerase eta
Names
DNA polymerase eta
RAD30 homolog A
xeroderma pigmentosum variant type protein
NP_006493.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.1

Summary This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Disorder

MIM: 603968

Xeroderma pigmentosum, variant type, 278750 (3)

mRNA Protein Product Sequence Price Select
NM_001291969, 634743303 NP_001278898, 634743304 DNA polymerase eta isoform 2 ORF Sequence $700.00
NM_001291970, 634743305 NP_001278899, 634743306 DNA polymerase eta isoform 3 ORF Sequence $400.00
NM_006502, 170650686 NP_006493, 5729982 DNA polymerase eta isoform 1 ORF Sequence $700.00
XM_005249186, 530382161 XP_005249243, 530382162 DNA polymerase eta isoform X1 ORF Sequence $700.00
XM_006715118, 578811742 XP_006715181, 578811743 DNA polymerase eta isoform X2 ORF Sequence $550.00
KEGG
hsa03460Fanconi anemia pathway
Reactome
REACT_216DNA Repair
REACT_2198Translesion synthesis by DNA polymerases bypassing lesion on DNA template
REACT_1287Translesion synthesis by Pol eta
REACT_2174DNA Damage Bypass
Homo sapiens (human)POLHNP_006493.1
Pan troglodytes (chimpanzee)POLHXP_518497.1
Macaca mulatta (Rhesus monkey)POLHXP_002803805.1
Canis lupus familiaris (dog)POLHXP_532150.2
Bos taurus (cattle)POLHNP_001029622.1
Mus musculus (house mouse)PolhNP_109640.1
Rattus norvegicus (Norway rat)PolhNP_001101674.1
Gallus gallus (chicken)POLHNP_001001304.1
Danio rerio (zebrafish)polhNP_001035337.1
Caenorhabditis eleganspolh-1NP_497480.2
Xenopus (Silurana) tropicalis (western clawed frog)polhXP_002942198.2
Process
IDNameEvidence
GO:0000731DNA synthesis involved in DNA repairIDA
GO:0006261DNA-dependent DNA replicationIEA
GO:0006261DNA-dependent DNA replicationTAS
GO:0006281DNA repairTAS
GO:0006282regulation of DNA repairTAS
GO:0006290pyrimidine dimer repairIEA
GO:0006301postreplication repairIEA
GO:0010225response to UV-CIDA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
Function
IDNameEvidence
GO:0003684damaged DNA bindingIEA
GO:0003887DNA-directed DNA polymerase activityTAS
GO:0005515protein bindingIPI
GO:0046872metal ion bindingIEA
GeneCards POLH
UniProt Q9Y253, B4DG64
Vega OTTHUMG00000014743
MIM 603968
Ensembl ENSG00000170734
HGNC 9181
HPRD 04913

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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