POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	POLR2L
Entrez Gene ID	5441
Full Name	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Synonyms	RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, hsRPB10b
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:11 Map Location:11p15
Summary	This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq].
Disorder	MIM: 601189

mRNA	NM_021128, 219879829
Protein	NP_066951, 10863925
Product	DNA-directed RNA polymerases I, II, and III subunit RPABC5
RefSeq Status	REVIEWED

KEGG

hsa03020	RNA polymerase
hsa05016	Huntington's disease
hsa00240	Pyrimidine metabolism
hsa01100	Metabolic pathways
hsa00230	Purine metabolism

WikiPathways

WP231

TNF-alpha/NF-kB Signaling Pathway

Reactome

REACT_2089	RNA Polymerase II Promoter Escape
REACT_6253	RNA Polymerase II HIV-1 Promoter Escape
REACT_71	Gene Expression
REACT_846	Formation of the Early Elongation Complex
REACT_6233	Transcription of the HIV genome
REACT_1735	mRNA Splicing
REACT_1371	RNA Polymerase III Transcription
REACT_756	RNA Polymerase III Chain Elongation
REACT_6274	HIV-1 Transcription Elongation
REACT_216	DNA Repair
REACT_1655	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REACT_6162	Tat-mediated elongation of the HIV-1 transcript
REACT_6152	Influenza Viral RNA Transcription and Replication
REACT_125	Processing of Capped Intron-Containing Pre-mRNA
REACT_1788	Transcription
REACT_6256	HIV Life Cycle
REACT_6261	Abortive elongation of HIV-1 transcript in the absence of Tat
REACT_1851	RNA Polymerase II Transcription Initiation
REACT_1753	mRNA Splicing - Minor Pathway
REACT_6332	HIV-1 Transcription Initiation
REACT_975	RNA Pol II CTD phosphorylation and interaction with CE
REACT_6354	Viral Messenger RNA Synthesis
REACT_1941	Formation of transcription-coupled NER (TC-NER) repair complex
REACT_6167	Influenza Infection
REACT_22201	Formation of HIV-1 elongation complex in the absence of HIV-1 Tat
REACT_6237	RNA Pol II CTD phosphorylation and interaction with CE
REACT_833	RNA Polymerase II Transcription Elongation
REACT_21352	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_12417	MicroRNA (miRNA) Biogenesis
REACT_6143	Pausing and recovery of Tat-mediated HIV-1 elongation
REACT_1845	Formation of RNA Pol II elongation complex
REACT_6319	Formation of the HIV-1 Early Elongation Complex
REACT_467	mRNA Splicing - Major Pathway
REACT_1675	mRNA Processing
REACT_1470	mRNA Capping
REACT_6346	Formation of HIV-1 elongation complex containing HIV-1 Tat
REACT_6344	Tat-mediated HIV-1 elongation arrest and recovery
REACT_22107	RNA Polymerase II Pre-transcription Events
REACT_347	RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_571	RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_6361	Late Phase of HIV Life Cycle
REACT_2039	Formation and Maturation of mRNA Transcript
REACT_6259	HIV-1 elongation arrest and recovery
REACT_63	RNA Polymerase III Transcription Termination
REACT_22339	RNA Polymerase III Abortive And Retractive Initiation
REACT_1628	Transcription-coupled NER (TC-NER)
REACT_6185	HIV Infection
REACT_1366	RNA Polymerase II Transcription
REACT_6244	Pausing and recovery of HIV-1 elongation
REACT_281	RNA Polymerase III Transcription Initiation
REACT_834	RNA Polymerase II Transcription Initiation And Promoter Clearance
REACT_2222	Dual incision reaction in TC-NER
REACT_1826	Nucleotide Excision Repair
REACT_6145	Influenza Life Cycle
REACT_12472	Regulatory RNA pathways
REACT_1036	RNA Polymerase III Transcription Initiation From Type 2 Promoter

Homo sapiens (human)	POLR2L	NP_066951.1
Pan troglodytes (chimpanzee)	POLR2L	XP_001151400.1
Bos taurus (cattle)	POLR2L	XP_001787735.1
Mus musculus (house mouse)	Gm10774	XP_001480824.1
Rattus norvegicus (Norway rat)	LOC681193	XP_001063101.1
Gallus gallus (chicken)	POLR2L	XP_001233059.1
Danio rerio (zebrafish)	zgc:112305	NP_001153297.1
Drosophila melanogaster (fruit fly)	Rpb10	NP_651280.1
Caenorhabditis elegans	rpb-10	NP_490923.1
Arabidopsis thaliana (thale cress)	AT1G61700	NP_176363.1

Process

ID	Name	Evidence
GO:0000398	nuclear mRNA splicing, via spliceosome	TAS
GO:0006281	DNA repair	TAS
GO:0006283	transcription-coupled nucleotide-excision repair	TAS
GO:0006289	nucleotide-excision repair	TAS
GO:0006356	regulation of transcription from RNA polymerase I promoter	TAS
GO:0006366	transcription from RNA polymerase II promoter	IDA
GO:0006366	transcription from RNA polymerase II promoter	TAS
GO:0006367	transcription initiation from RNA polymerase II promoter	EXP
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0006368	transcription elongation from RNA polymerase II promoter	EXP
GO:0006368	transcription elongation from RNA polymerase II promoter	TAS
GO:0006370	mRNA capping	TAS
GO:0006383	transcription from RNA polymerase III promoter	TAS
GO:0006385	transcription elongation from RNA polymerase III promoter	TAS
GO:0006386	termination of RNA polymerase III transcription	TAS
GO:0008380	RNA splicing	EXP
GO:0010467	gene expression	TAS
GO:0016032	viral reproduction	TAS
GO:0050434	positive regulation of viral transcription	TAS

Component

ID	Name	Evidence
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	EXP
GO:0005654	nucleoplasm	TAS
GO:0005665	DNA-directed RNA polymerase II, core complex	IDA

Function

ID	Name	Evidence
GO:0003677	DNA binding	IEA
GO:0003899	DNA-directed RNA polymerase activity	IEA
GO:0004672	protein kinase activity	IDA
GO:0008270	zinc ion binding	IEA
GO:0046872	metal ion binding	IEA

GeneCards	POLR2L
UniProt	P62875
MIM	601189
Ensembl	ENSG00000177700
HGNC	9199
HPRD	01155

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RefSeq Accession	Definition	Sequence	Price	Select
NM_021128	Homo sapiens polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa (POLR2L), mRNA.	Full Length	$268.25
NM_021128		ORF Sequence	$159.00