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POR P450 (cytochrome) oxidoreductase [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000941 Homo sapiens P450 (cytochrome) oxidoreductase (POR), mRNA. ORF Sequence $592.47
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Gene Symbol POR
Entrez Gene ID 5447
Full Name P450 (cytochrome) oxidoreductase
Synonyms CPR, CYPOR, DKFZp686G04235, FLJ26468, P450R
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q11.2

Summary This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008].
Disorder

MIM: 124015

Antley-Bixler syndrome with genital anomalies and disordered

mRNA Protein Product Sequence Price Select
NM_000941, 94721355 NP_000932, 127139033 NADPH--cytochrome P450 reductase Full Length $727.61
ORF Sequence $592.47
WikiPathways
WP43cytochrome P450
BIOCYC
HUMAN_PWY-60761,25-dihydroxyvitamin D3 biosynthesis
META_PWY-6402superpathway of melatonin degradation
HUMAN_PWY-6402superpathway of melatonin degradation
HUMAN_PWY-6061bile acid biosynthesis, neutral pathway
HUMAN_PWY-6398melatonin degradation I
META_PWY-6398melatonin degradation I
Homo sapiens (human)PORNP_000932.3
Pan troglodytes (chimpanzee)PORXP_001155755.2
Macaca mulatta (Rhesus monkey)PORXP_001109664.1
Canis lupus familiaris (dog)PORNP_001171276.1
Bos taurus (cattle)PORNP_001030467.1
Mus musculus (house mouse)PorNP_032924.1
Rattus norvegicus (Norway rat)PorNP_113764.1
Gallus gallus (chicken)PORNP_001182725.1
Danio rerio (zebrafish)porNP_001030154.1
Drosophila melanogaster (fruit fly)CprNP_477158.1
Caenorhabditis elegansemb-8NP_498103.1
Arabidopsis thaliana (thale cress)ATR1NP_194183.1
GeneCards POR
PDB 3QE2, 3QFR, 3QFC, 3QFT, 3QFS, 1B1C, 3FJO
UniProt P16435
MIM 124015
Ensembl ENSG00000127948
HGNC 9208
HPRD 00485

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
NADPH--cytochrome P450 reductase
Names
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome P450 reductase
NP_000932.3

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