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POR P450 (cytochrome) oxidoreductase [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000941 Homo sapiens P450 (cytochrome) oxidoreductase (POR), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

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Gene Symbol POR
Entrez Gene ID 5447
Full Name P450 (cytochrome) oxidoreductase
Synonyms CPR, CYPOR, P450R
General protein information
Preferred Names
NADPH--cytochrome P450 reductase
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome P450 reductase
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008].

MIM: 124015

Antley-Bixler syndrome with genital anomalies and disordered

mRNA Protein Product Sequence Price Select
NM_000941, 94721355 NP_000932, 127139033 NADPH--cytochrome P450 reductase ORF Sequence $490.00
WP43cytochrome P450
META_PWY-60761,25-dihydroxyvitamin D3 biosynthesis
HUMAN_PWY-6398melatonin degradation I
HUMAN_PWY-60761,25-dihydroxyvitamin D3 biosynthesis
HUMAN_PWY-6402superpathway of melatonin degradation
META_PWY-6398melatonin degradation I
META_PWY-6402superpathway of melatonin degradation
HUMAN_PWY-6061bile acid biosynthesis, neutral pathway
Homo sapiens (human)PORNP_000932.3
Pan troglodytes (chimpanzee)PORXP_001155755.2
Macaca mulatta (Rhesus monkey)PORXP_001109664.1
Canis lupus familiaris (dog)PORNP_001171276.1
Bos taurus (cattle)PORNP_001030467.1
Mus musculus (house mouse)PorNP_032924.1
Rattus norvegicus (Norway rat)PorNP_113764.1
Gallus gallus (chicken)PORNP_001182725.1
Danio rerio (zebrafish)porNP_001030154.1
Drosophila melanogaster (fruit fly)CprNP_001260128.1
Caenorhabditis elegansemb-8NP_498103.1
Arabidopsis thaliana (thale cress)ATR2NP_849472.2
Xenopus (Silurana) tropicalis (western clawed frog)porXP_002933864.1
GO:0003420regulation of growth plate cartilage chondrocyte proliferationIEA
GO:0007584response to nutrientIEA
GO:0009437carnitine metabolic processIEA
GO:0009812flavonoid metabolic processIEA
GO:0018393internal peptidyl-lysine acetylationIEA
GO:0019395fatty acid oxidationIEA
GO:0032332positive regulation of chondrocyte differentiationIEA
GO:0032770positive regulation of monooxygenase activityIDA
GO:0042493response to drugIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0043602nitrate catabolic processIEA
GO:0045542positive regulation of cholesterol biosynthetic processIEA
GO:0045880positive regulation of smoothened signaling pathwayIEA
GO:0046210nitric oxide catabolic processIEA
GO:0055114oxidation-reduction processIDA
GO:0055114oxidation-reduction processTAS
GO:0060192negative regulation of lipase activityIEA
GO:0071372cellular response to follicle-stimulating hormone stimulusIEA
GO:0071375cellular response to peptide hormone stimulusIEA
GO:0090031positive regulation of steroid hormone biosynthetic processIEA
GO:0090346cellular organofluorine metabolic processIDA
GO:0005789endoplasmic reticulum membraneIEA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0003958NADPH-hemoprotein reductase activityIDA
GO:0003958NADPH-hemoprotein reductase activityTAS
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)HIEA
GO:0005506iron ion bindingIEA
GO:0005515protein bindingIPI
GO:0008941nitric oxide dioxygenase activityIEA
GO:0009055electron carrier activityIEA
GO:0010181FMN bindingIEA
GO:0016787hydrolase activityIEA
GO:0019899enzyme bindingIEA
GO:0047726iron-cytochrome-c reductase activityIEA
GO:0050660flavin adenine dinucleotide bindingIEA
GO:0050661NADP bindingIEA
GeneCards POR
PDB 3QE2, 3QFR, 3QFC, 3QFT, 3QFS, 1B1C, 3FJO
UniProt P16435
Vega OTTHUMG00000130413
MIM 124015
Ensembl ENSG00000127948
HGNC 9208
HPRD 00485

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the POR gene?

The POR gene provides instructions for making the enzyme cytochrome P450 oxidoreductase. This enzyme is required for the normal functioning of more than 50 enzymes in the cytochrome P450 family. Cytochrome P450 enzymes are involved in the formation (synthesis) and breakdown (metabolism) of various molecules and chemicals within cells.

Cytochrome P450 enzymes are critical for the synthesis of cholesterol and steroid hormones. Cholesterol is a substance that has many essential functions both before and after birth, including roles in the production of steroid hormones and in the formation and growth of bones. Steroid hormones are needed for normal development and reproduction. This group of hormones includes testosterone and estrogen, which are essential for normal sexual development and reproduction; corticosteroids, which are involved in the body's response to stress; and aldosterone, which helps regulate the body's salt and water balance.

Additionally, cytochrome P450 enzymes are involved in the metabolism of ingested substances, such as medications, in the liver. Because cytochrome P450 oxidoreductase helps regulate the activity of these enzymes, researchers suspect that normal variations in the POR gene may influence a person's response to particular drugs (drug metabolism).


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