POR P450 (cytochrome) oxidoreductase [Homo sapiens (human)]
| Gene Symbol | POR |
| Entrez Gene ID | 5447 |
| Full Name | P450 (cytochrome) oxidoreductase |
| Synonyms | CPR, CYPOR, DKFZp686G04235, FLJ26468, P450R |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7q11.2 |
| Summary | This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq]. |
| Disorder | MIM: 124015 Antley-Bixler syndrome with genital anomalies and disordered |
| mRNA | NM_000941, 94721355 |
| Protein | NP_000932, 127139033 |
| Product | NADPH--cytochrome P450 reductase |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | POR | NP_000932.3 |
| Pan troglodytes (chimpanzee) | POR | XP_001155498.1 |
| Canis lupus familiaris (dog) | POR | XP_858049.1 |
| Bos taurus (cattle) | POR | NP_001030467.1 |
| Mus musculus (house mouse) | Por | NP_032924.1 |
| Rattus norvegicus (Norway rat) | Por | NP_113764.1 |
| Gallus gallus (chicken) | POR | XP_415768.2 |
| Danio rerio (zebrafish) | por | NP_001030154.1 |
| Drosophila melanogaster (fruit fly) | Cpr | NP_477158.1 |
| Caenorhabditis elegans | emb-8 | NP_498103.1 |
| Arabidopsis thaliana (thale cress) | ATR1 | NP_194183.1 |
| ID | Name | Evidence |
| GO:0032770 | positive regulation of monooxygenase activity | IDA |
| GO:0046210 | nitric oxide catabolic process | IEA |
| GO:0055114 | oxidation-reduction process | IDA |
| GO:0055114 | oxidation-reduction process | TAS |
| GO:0071375 | cellular response to peptide hormone stimulus | IEA |
| GO:0090181 | regulation of cholesterol metabolic process | IEA |
| GO:0090346 | cellular organofluorine metabolic process | IDA |
Component
| ID | Name | Evidence |
| GO:0005625 | soluble fraction | IEA |
| GO:0005739 | mitochondrion | IEA |
| GO:0005783 | endoplasmic reticulum | TAS |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| GO:0005792 | microsome | IEA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0003958 | NADPH-hemoprotein reductase activity | IDA |
| GO:0003958 | NADPH-hemoprotein reductase activity | TAS |
| GO:0005506 | iron ion binding | IEA |
| GO:0010181 | FMN binding | IEA |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0019899 | enzyme binding | IEA |
| GO:0050660 | flavin adenine dinucleotide binding | IEA |
| GO:0050661 | NADP binding | IEA |
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