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POU1F1 POU class 1 homeobox 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23455 NM_001122757 Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant beta, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu23957 NM_000306 Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant alpha, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu23455C NM_001122757 Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant beta, mRNA. Customized vector On-demand 7-9 $209.00
OHu23957C NM_000306 Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant alpha, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol POU1F1
Entrez Gene ID 5449
Full Name POU class 1 homeobox 1
Synonyms CPHD1, GHF-1, PIT1, POU1F1a, Pit-1
General protein information
Preferred Names
pituitary-specific positive transcription factor 1
Names
pituitary-specific positive transcription factor 1
growth hormone factor 1
pituitary-specific transcription factor 1
POU domain, class 1, transcription factor 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p11

Summary This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 173110

Pituitary hormone deficiency, combined, 1, 613038 (3)

mRNA Protein Product Sequence Price Select
NM_000306, 574957194 NP_000297, 4505955 pituitary-specific positive transcription factor 1 isoform alpha ORF Sequence $300.00
NM_001122757, 574957078 NP_001116229, 170650730 pituitary-specific positive transcription factor 1 isoform beta ORF Sequence $400.00
Pathway Interaction Database
reg_gr_pathwayGlucocorticoid receptor regulatory network
Homo sapiens (human)POU1F1NP_001116229.1
Pan troglodytes (chimpanzee)POU1F1XP_003318250.1
Macaca mulatta (Rhesus monkey)POU1F1NP_001036325.1
Canis lupus familiaris (dog)POU1F1NP_001006950.1
Bos taurus (cattle)POU1F1NP_777004.1
Mus musculus (house mouse)Pou1f1NP_032875.1
Rattus norvegicus (Norway rat)Pou1f1NP_037140.2
Gallus gallus (chicken)POU1F1NP_989650.1
Danio rerio (zebrafish)pou1f1NP_998016.1
Xenopus (Silurana) tropicalis (western clawed frog)pou1f1XP_002931806.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001708cell fate specificationIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0008284positive regulation of cell proliferationIEA
GO:0008285negative regulation of cell proliferationTAS
GO:0008340determination of adult lifespanIEA
GO:0030183B cell differentiationIEA
GO:0032962positive regulation of inositol trisphosphate biosynthetic processIEA
GO:0040018positive regulation of multicellular organism growthIEA
GO:0043567regulation of insulin-like growth factor receptor signaling pathwayIEA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0051169nuclear transportIEA
GO:0060133somatotropin secreting cell developmentIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0001105RNA polymerase II transcription coactivator activityIDA
GO:0003682chromatin bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003714transcription corepressor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards POU1F1
UniProt P28069
Vega OTTHUMG00000158992
MIM 173110
Ensembl ENSG00000064835
HGNC 9210
HPRD 01409

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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