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ATR ATR serine/threonine kinase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28276 NM_001184 Homo sapiens ATR serine/threonine kinase (ATR), mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu28276C NM_001184 Homo sapiens ATR serine/threonine kinase (ATR), mRNA. Customized vector On-demand 35 $3749.00

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Gene Symbol ATR
Entrez Gene ID 545
Full Name ATR serine/threonine kinase
Synonyms FCTCS, FRP1, MEC1, SCKL, SCKL1
General protein information
Preferred Names
serine/threonine-protein kinase ATR
Names
serine/threonine-protein kinase ATR
protein kinase ATR
Rad3 related protein
FRAP-related protein 1
FRAP-related protein-1
MEC1, mitosis entry checkpoint 1, homolog
ataxia telangiectasia and Rad3-related protein
NP_001175.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q23

Summary The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601215

Seckel syndrome 1, 210600 (3)

mRNA Protein Product Sequence Price Select
NM_001184, 157266316 NP_001175, 157266317 serine/threonine-protein kinase ATR ORF Sequence $3500.00
KEGG
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection
hsa03460Fanconi anemia pathway
WikiPathways
WP707DNA damage response
WP1984Integrated Breast Cancer Pathway
WP179Cell cycle
WP1971Integrated Cancer pathway
WP2263Prostate Cancer
Pathway Interaction Database
bard1pathwayBARD1 signaling events
circadianpathwayCircadian rhythm pathway
p53regulationpathwayp53 pathway
tcptp_pathwaySignaling events mediated by TCPTP
Reactome
REACT_1538Cell Cycle Checkpoints
REACT_897G2/M DNA damage checkpoint
REACT_6769Activation of ATR in response to replication stress
REACT_828G2/M Checkpoints
REACT_216DNA Repair
REACT_18410Fanconi Anemia pathway
REACT_18265Regulation of the Fanconi anemia pathway
REACT_111183Meiosis
REACT_75792Meiotic synapsis
REACT_115566Cell Cycle
REACT_120956Cellular responses to stress
REACT_200819Cellular response to heat stress
REACT_200780Regulation of HSF1-mediated heat shock response
Homo sapiens (human)ATRNP_001175.2
Pan troglodytes (chimpanzee)ATRXP_516792.3
Macaca mulatta (Rhesus monkey)ATRXP_001112149.1
Canis lupus familiaris (dog)ATRXP_003639878.1
Bos taurus (cattle)ATRXP_002685103.2
Mus musculus (house mouse)AtrNP_063917.1
Rattus norvegicus (Norway rat)AtrXP_003750609.1
Gallus gallus (chicken)ATRXP_003641789.1
Danio rerio (zebrafish)atrXP_696163.5
Xenopus (Silurana) tropicalis (western clawed frog)atrXP_002937136.2
Process
IDNameEvidence
GO:0000077DNA damage checkpointIDA
GO:0006260DNA replicationTAS
GO:0006281DNA repairTAS
GO:0006974cellular response to DNA damage stimulusTAS
GO:0007049cell cycleTAS
GO:0007275multicellular organismal developmentTAS
GO:0008156negative regulation of DNA replicationIMP
GO:0018105peptidyl-serine phosphorylationIDA
GO:0034644cellular response to UVIMP
GO:0042493response to drugIEA
GO:0043393regulation of protein bindingIEA
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediatorIMP
GO:0046777protein autophosphorylationIDA
GO:0071480cellular response to gamma radiationIDA
GO:0090399replicative senescenceIMP
Component
IDNameEvidence
GO:0001741XY bodyIEA
GO:0005654nucleoplasmTAS
GO:0005694chromosomeISS
GO:0016605PML bodyIDA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0004672protein kinase activityIDA
GO:0004674protein serine/threonine kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0032405MutLalpha complex bindingIDA
GO:0032407MutSalpha complex bindingIDA
GeneCards ATR
UniProt Q13535
Vega OTTHUMG00000159234
MIM 601215
Ensembl ENSG00000175054
HGNC 882
HPRD 08369

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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