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ATR ataxia telangiectasia and Rad3 related [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001184 Homo sapiens ataxia telangiectasia and Rad3 related (ATR), mRNA. GenEZ ORF Cloning On-demand $3749.00 35

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Gene Symbol ATR
Entrez Gene ID 545
Full Name ataxia telangiectasia and Rad3 related
Synonyms FRP1, MEC1, SCKL, SCKL1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q22-q24

Summary The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601215

Seckel syndrome 1, 210600 (3)

mRNA Protein Product Sequence Price Select
NM_001184, 157266316 NP_001175, 157266317 serine/threonine-protein kinase ATR ORF Sequence $3500.00
KEGG
hsa04115p53 signaling pathway
hsa03460Fanconi anemia pathway
hsa05166HTLV-I infection
hsa04110Cell cycle
WikiPathways
WP707DNA damage response
WP1984Integrated Breast Cancer Pathway
WP1971Integrated Cancer pathway
Pathway Interaction Database
circadianpathwayCircadian rhythm pathway
bard1pathwayBARD1 signaling events
p53regulationpathwayp53 pathway
tcptp_pathwaySignaling events mediated by TCPTP
Reactome
REACT_897G2/M DNA damage checkpoint
REACT_115566Cell Cycle
REACT_216DNA Repair
REACT_6769Activation of ATR in response to replication stress
REACT_18265Regulation of the Fanconi anemia pathway
REACT_18410Fanconi Anemia pathway
REACT_111183Meiosis
REACT_1538Cell Cycle Checkpoints
REACT_22172Chromosome Maintenance
REACT_75792Meiotic Synapsis
REACT_828G2/M Checkpoints
Homo sapiens (human)ATRNP_001175.2
Pan troglodytes (chimpanzee)ATRXP_516792.3
Macaca mulatta (Rhesus monkey)ATRXP_001112149.1
Canis lupus familiaris (dog)LOC100856315XP_003639878.1
Bos taurus (cattle)ATRXP_002685103.2
Mus musculus (house mouse)AtrNP_063917.1
Gallus gallus (chicken)ATRXP_003641789.1
Danio rerio (zebrafish)atrXP_696163.4
GeneCards ATR
UniProt Q13535
MIM 601215
Ensembl ENSG00000175054
HGNC 882
HPRD 08369

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
serine/threonine-protein kinase ATR
Names
serine/threonine-protein kinase ATR
protein kinase ATR
Rad3 related protein
FRAP-related protein 1
FRAP-related protein-1
MEC1, mitosis entry checkpoint 1, homolog
ataxia telangiectasia and Rad3-related protein
NP_001175.2

Interactant



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