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POU3F2 POU class 3 homeobox 2 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_005604 Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA. Full Length $1460.20
ORF Sequence $386.28


Gene Symbol POU3F2
Entrez Gene ID 5454
Full Name POU class 3 homeobox 2
Synonyms BRN2, OCT7, OTF7, POUF3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q16
Summary POU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski et al., 1995 [PubMed 7601453]).[supplied by OMIM].
Disorder

MIM: 600494
mRNA NM_005604, 51702520
Protein NP_005595, 51702521
Product POU domain, class 3, transcription factor 2
RefSeq Status VALIDATED
WikiPathways
WP706SIDS Susceptibility Pathways
Homo sapiens (human)POU3F2NP_005595.2
Canis lupus familiaris (dog)POU3F2XP_539052.2
Bos taurus (cattle)POU3F2NP_001073817.1
Mus musculus (house mouse)Pou3f2NP_032925.1
Rattus norvegicus (Norway rat)Pou3f2XP_345511.1
Danio rerio (zebrafish)pou3f2NP_571235.1
Drosophila melanogaster (fruit fly)vvlNP_001163355.1
Process
IDNameEvidence
GO:0006351transcription, DNA-dependentTAS
GO:0008284positive regulation of cell proliferationIDA
GO:0008544epidermis developmentIEA
GO:0014002astrocyte developmentIEA
GO:0021799cerebral cortex radially oriented cell migrationIEA
GO:0021869forebrain ventricular zone progenitor cell divisionIEA
GO:0021979hypothalamus cell differentiationIEA
GO:0021985neurohypophysis developmentIEA
GO:0022011myelination in peripheral nervous systemIEA
GO:0030182neuron differentiationIEA
GO:0040018positive regulation of multicellular organism growthIEA
GO:0045595regulation of cell differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0050770regulation of axonogenesisIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005667transcription factor complexIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GO:0043565sequence-specific DNA bindingIEA
GeneCards POU3F2
UniProt B3KTH8, P20265
MIM 600494
Ensembl ENSG00000184486
HGNC 9215
HPRD 02734

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